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Potassium difluoroacetate CAS 6291-26-5

Potassium difluoroacetate | potassium,2,2-difluoroacetic acid

CAS 6291-26-5 | C2HF2KO2 | 134.123

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Potassium difluoroacetate Supplier & Manufacturer

Basic Info of Potassium difluoroacetate

CAS No:6291-26-5
Name:Potassium difluoroacetate
Formula:C2HF2KO2
Weight:134.123
EINECS:208-407-7
Other Names:potassium,2,2-difluoroacetic acid
Type:Organic Intermediate, Pharmaceutical Intermediates
Shelf Life:3 years
Brand Name:Zhishang Chemical
Place of Origin:China

What is Potassium difluoroacetate?

Potassium difluoroacetate (KFA) is a fluoride salt with the molecular formula C ₂ HF ₂ KO ₂ and a molecular weight of approximately 134.12 g/mol. It is the potassium salt of difluoroacetic acid and possesses unique chemical and organic buildings. The acetate moiety of Potassium difluoroacetate has 2 fluorine atoms affixed to the α-carbon; their strong electron-withdrawing effect stabilizes the carboxylate anion and influences the reactivity of the substance. Potassium difluoroacetate is a white crystalline strong, soluble in water and polar organic solvents.

Potassium difluoroacetate can participate in a variety of chain reactions. It displays high task in esterification, alkylation, and other natural synthesis responses. The fluorine atoms in Potassium difluoroacetate improve the polarity of the particle and affect its chain reaction pathway. It can additionally be utilized in logical chemistry to identify the make-up and concentration of various compounds. It is made use of in biological study, cell society, and analysis to help scientists research cellular life tasks. It can likewise work as a reagent to affect organic metabolism. Its special homes make it ideal for numerous fields.

Preparation

  • The primary basic materials for the synthesis of potassium fluoride are fluorosilicic acid and potassium hydroxide. The specific prep work steps are as adheres to:
  • A fluorosilicic acid service is blended with potassium hydroxide and reacted. The response is finished in about 10 to 60 mins. The combination is then filteringed system to obtain a solid product of potassium fluorosilicate. The obtained potassium fluorosilicate undergoes high-temperature therapy (300 to 800 ° C) to remove moisture and improve product purity.
  • During the synthesis procedure, cautious control of the reaction temperature and time is needed to obtain a high-purity target item. Pertinent security policies must be followed throughout operation to ensure secure production.

Potassium difluoroacetate Uses

Potassium difluoroacetate is mostly utilized as a fluorination intermediate in organic synthesis. It is additionally a source of difluoroacetyl or difluoromethyl anionic equivalents, which can be presented right into nucleophilic substratums to create esters, amides, and various other functionalized compounds. 

Compared to the equivalent acids or anhydrides, potassium difluoroacetate is stable and very easy to handle, making it a convenient reagent in laboratory-scale reactions and commercial manufacturing. The sensitivity of potassium difluoroacetate is of terrific use in the prep work of drugs, agrochemicals, and specialty chemicals needing fluorine-containing teams.

Potassium difluoroacetate is made use of to synthesize difluoromethylation intermediates for medication advancement. Difluoromethyl teams boost the metabolic stability, lipophilicity, and bioavailability of target particles. This substance is extremely useful in manufacturing enzyme preventions, antiviral medications, and other bioactive molecules, where selective fluorination improves their chemical security and biological buildings. 

The potassium salt kind allows for responses under mild conditions, assisting in selective functionalization without impacting sensitive useful teams in complicated particles.

Potassium difluoroacetate is an intermediate in the preparation of fluorinated herbicides, fungicides, and pesticides. Difluoromethyl teams improve their chemical and thermal stability, biological activity, and ecological longevity. It can efficiently include fluorinated domains into forerunner particles, simplifying the synthesis of energetic substances and intermediates for plant protection applications.

Fluorinated intermediates derived from potassium difluoroacetate present difluoromethyl groups right into polymers, materials, and layers, enhancing the hydrophobicity, chemical resistance, and thermal security of the products. The solubility and stability of potassium difluoroacetate assist in discerning responses and binding to intricate molecular structures, making it a versatile and advanced useful materials reagent.

Specifications & Packaging

Product Packaging

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Application of Potassium difluoroacetate

Over the last few years, international demand for fluorides has raised dramatically, primarily driven by the farming field’s need for extremely effective pesticides and plant foods. As an example, fluorides can function as intermediates in certain chemicals, promoting the production and use of relevant products. The application of fluorides in fine chemical products has actually additionally broadened market need.

  • Drug Industry
  • Potassium difluoroacetate is generally utilized as a resources in synthetic reactions. It can be made use of in the trifluoromethylation of drugs, and related compounds can be made use of to deal with various illness, such as autoimmune illness and inflammatory conditions like enteritis and rheumatoid joint inflammation. The intro of potassium difluoroacetate can also boost the bioactivity and selectivity of drugs.
  • Chemical Synthesis
  • Potassium difluoroacetate is frequently utilized in natural synthesis responses. As a fluorinating agent, it can present fluorine atoms into organic molecules, altering their physical and chemical homes. This fluorinated compound has one-of-a-kind applications in medicine synthesis and the development of new products.
  • Chemical Production
  • Potassium difluoroacetate is utilized in farming, especially in the manufacture of pesticides. Potassium difluoroacetate is an important basic material for the synthesis of insecticides such as sodium fluoroacetate and fluoroacetamide, which properly manage insects and enhance plant yield and high quality.
  • Biochemical Research
  • In biochemical research, potassium difluoroacetate is utilized as a prevention to impact particular metabolic pathways. It exhibits sensitivity selectivity in some organic systems and is generally used to study biomolecules and cellular processes, with wide applications in cell culture and analysis, professional and diagnostic study.
  • Analytical Chemistry
  • Potassium difluoroacetate is mainly made use of as a conventional substance for mass spectrometry, nuclear magnetic resonance (NMR), and various other spectroscopic evaluations. Its security and one-of-a-kind spectral attributes make it a crucial tool for examining the framework and residential properties of substances.

The exploration and continued use potassium difluoroacetate demonstrates the relevance of this one-of-a-kind and flexible fluoride salt. Its chemical stability, sensitivity, and electron-withdrawing residential or commercial properties make it an important intermediate in modern organic synthesis, playing a considerable role in pharmaceuticals, agrochemicals, and products science.

This substance has reasonably stable physicochemical buildings and typically exists in solid kind. Its storage space and dealing with need keeping it completely dry and awesome to stop degradation.

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Potassium difluoroacetate Supplier and Manufacturer

As a Potassium difluoroacetate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best Potassium difluoroacetate raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for Potassium difluoroacetate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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