Vitamin B12 Cobalamin CAS 68-19-9
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Factory Supply Vitamin B12 Cobalamin CAS 68-19-9 with Best Price
- Appearance: Red powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Vitamin B12 Cobalamin Supplier & Manufacturer
Vitamin B12 Cobalamin: The Complete Guide
- Item 1: Basic Info of Vitamin B12 Cobalamin
- Item 2: What is Vitamin B12 Cobalamin?
- Item 3: Vitamin B12 Cobalamin Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Vitamin B12 Cobalamin
- Item 6: Causes and Diseases of Vitamin B12 Cobalamin Deficiency
- Item 7: Quality Control of Vitamin B12 Cobalamin
- Item 8: Hot Sale Products
- Item 9: Get Vitamin B12 Cobalamin Quotation
Vitamin B12 Cobalamin for Sale
Basic Info of Vitamin B12 Cobalamin
Basic Info
Chemical Properties
Other Info
Basic Info
Chemical Name: | Vitamin B12 Cobalamin |
Other Name: | Vitamin B12; Cobalamin; Cyanocobalamin b12; Vitamin b12 cyanocobalamin |
CAS: | 68-19-9 |
EINECS: | 200-680-0 |
Type: | Food additives; Pharmaceutical raw materials; Organic raw materials; Plant extracts; Flavors and fragrances; Daily chemicals; Pharmaceuticals, pesticides, dye intermediates |
Molecular Formula: | C63H88CoN14O14P |
Molecular Weight: | 1355.37 |
Chemical Properties
Melting point | >300°C |
alpha | 23656 -59 ± 9° (dil aq soln) |
Boiling point | >300 °C |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic. |
pka | pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain) |
form | Crystalline Powder or Crystals |
color | Red to dark red |
Water Solubility | Soluble |
Sensitive | Hygroscopic |
Exposure limits | NIOSH: IDLH 25 mg/m3 |
Stability: | Hygroscopic. Keep cold and dry. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Vitamin B12 Cobalamin MSDS; Vitamin B12 Cobalamin COA |
What is Vitamin B12 Cobalamin?
Cyanocobalamin (cbl), also known as vitamin B12, is a class of water-soluble compounds containing cobalt. Different forms of cobalt have been discovered since the 1960s. The first one was cyanocobalamin, followed by methylcobalt. Amine, Hydroxocobalamin and Adenosylcobalamin, among which Hydroxocobalamin belongs to the natural form of Cyanocobalamin and exists in food, and the other three forms need to be industrially synthesized. As an important cofactor in the body, cyanocobalamin plays a key role in the methionine (methionine) cycle of homocysteine metabolism and the isomerization of methylmalonic acid-succinic acid. Oxidative stress, intracellular signal transduction, apoptosis and other processes.
Cyanocobalamin in nature is synthesized by microbes. Higher animals and plants can not manufacture cyanocobalamin by themselves. Consequently, the human body needs to ingest it via animal food, including milk, eggs, fish and meat. The American Institute of Medicine suggests that the intake of cyanocobalamin is 2.4 μg/ d, as well as the Chinese Nutrition Association advises 1.0-3.2 μg/ d.
Generally, vitamin B12 can promote the growth as well as maturation of red cell, maintain the body’s hematopoietic feature in a regular state, protect against pernicious anemia, maintain the wellness of the nerve system, and also promote protein synthesis. Jaclyn London, MS, RD, CDN, Supervisor of Nourishment at The Good Home cleaning Institute, claimed: “As you age, getting B12 daily is critical as a shortage can lead to cognitive decline and also impaired neurological feature. Vitamin B12 is necessary in the human body. In biochemical responses, it is associated with DNA synthesis, change of damaging substances, and so on, and also is closely related to the maturation of blood cells, preserving the wellness of blood vessels as well as nervous system. Lack of B12 might result in neurological signs and symptoms such as megaloblastic anemia, vascular sclerosis and depression.
Vitamin B12 Cobalamin Uses
Vitamin B12 plays a very crucial role in several functions of the body, consisting of: DNA synthesis, energy manufacturing, keeping the wellness of afferent neuron, red cell development, nervous system feature. B12 is found in lots of foods and is bound in the healthy protein particles of the food.
Some common indications of vitamin B12 shortage include: lowered cognitive function, such as troubles with memory or understanding, tiredness, sleepiness, bowel irregularity, vague feelings, clinical depression or irritation, frustration, problem maintaining equilibrium, sore tongue, mouth sores, really feel numb,
Visual modifications. Risk factors for vitamin B12 shortage are also related to insulin levels, so some medications for type 2 diabetes mellitus can raise the danger of vitamin B12 shortage. In addition, the complying with threat aspects can additionally enhance the chance of vitamin B12 shortage: alcoholic abuse, cigarette smoking, taking specific prescription medications, consisting of antacids and also some type 2 diabetes medicines, having an autoimmune condition such as diabetes or thyroid disease, pure vegan diet regimen, certain food poisonings such as Crohn’s disease, gastric bypass surgery or removal of part of the belly, aging, have stomach problems, this is because an irregular gastrointestinal tract may prevent vitamin B12 release or take in.
Vitamin B12 injections, which do not damage the intestinal tract, can likewise lower the danger of vitamin B12 deficiency and also relevant issues. Complications of extreme vitamin B12 shortage include: cardiovascular disease, neurocognitive problems, sychronisation troubles, outer neuropathy, vision loss, the inability to conceive, and also much more.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Vitamin B12 Cobalamin
Medical as well as medical care applications
It is generally utilized to deal with different VB12 deficiency, such as: megaloblastic anemia, anemia triggered by medication poisoning, aplastic anemia and leukopenia, and so on; made use of in combination with pantothenic acid, it can stop destructive anemia and help Absorption of Fe2+ and also secretion of stomach acid; likewise utilized to deal with joint inflammation, facial nerve palsy, trigeminal neuralgia, liver disease, herpes, bronchial asthma and also various other allergies, atopic dermatitis, hives, dermatitis and also bursitis; VB12 can also For the therapy of anxiety, irritation, sleeplessness, memory loss, and anxiety. New research study suggests that VB12 deficiency additionally adds to mental disorders such as clinical depression. VB12 is very risk-free as a healing representative or health care product, and also no poisoning phenomenon was found by intravenous or intramuscular injection of VB12 that was several thousand times greater than RDA.- Application in feed
VB12 can promote the development as well as growth of fowl and also animals, especially young birds and also young animals, and also enhance the use rate of feed healthy protein, so it can be utilized as a feed additive. Dealing with fish eggs or fry with VB12 aqueous solution can enhance the tolerance of fish to poisonous substances in water such as benzene and also heavy metals, as well as decrease mortality. Considering that the “Mad Cow Illness” incident in Europe, using dietary supplements with clear chemical structures such as vitamins to replace “meat and also bone dish” has even more room for advancement. The majority of the VB12 generated worldwide is presently used in the feed market. - Application in other aspects
In industrialized countries, VB12 and other substances are made use of in cosmetics; in the food market, VB12 can be utilized as a colorant for pork, sausage, gelato, fish sauce and other foods. In domesticity, VB12 remedy is adsorbed on turned on carbon, zeolite, non-woven fiber or paper, or made right into soap, toothpaste, etc; it can be utilized for deodorization of commodes, refrigerators, and so on, and also eliminate the odor of sulfide and also aldehyde; VB12 can also be used Dehalogenation of natural halides, typical contaminants in soil as well as surface area water in environmental protection.
Causes and Diseases of Vitamin B12 Cobalamin Deficiency
Causes of Vitamin B12 Deficiency
Vitamin B12 deficiency and disease
Causes of Vitamin B12 Deficiency
- Too little intake
The human body cannot synthesize vitamin B12. Dietary vitamin B12 comes from animal foods, and milk and dairy products contain less vitamin B12. Plant foods basically do not contain vitamin B12. Vegetarians are more prone to vitamin B12 deficiency than non-vegetarians. Vitamin B12 intake was positively correlated with serum vitamin B12 levels. A mother’s vitamin B12 deficiency or insufficient intake may lead to a baby’s vitamin B12 deficiency due to low vitamin B12 levels in breast milk. - Malabsorption
Elderly people are prone to vitamin B12 deficiency, and about 60% of them are due to poor absorption of cobalamin bound in food due to gastrointestinal reasons. Taking more than 12-30 μg of synthetic vitamin B12 per day can reduce the risk of low vitamin B12 and high MMA in the elderly. Oral high doses of vitamin B12 can restore the MMA of most vitamin B12-deficient elderly people to normal. - Intrinsic factor deficiency
Vitamin B12 needs to be combined with intrinsic factor in order to be finally absorbed. Patients with pernicious anemia produce autoimmune antibodies to intrinsic factor, which can lead to severe vitamin B12 deficiency. - Others
Taking antiepileptic drugs, metformin, histamine H2 receptor inhibitors and proton pump inhibitors, hereditary cobalamin II deficiency, tropical sprue diarrhea, Helicobacter pylori infection, parasitic infection, etc., can also lead to vitamin B12 of lack.
Vitamin B12 deficiency and disease
- Anemia
Anemia caused by vitamin B12 deficiency, like a lack of folic acid, is also megaloblastic anemia. However, vitamin B12 deficiency was not associated with anemia, neither in the elderly nor in those with a low intake of animal-derived foods. Vitamin B12 supplementation does not affect complete blood counts in people with vitamin B12 deficiency. - Hyperhomocysteinemia
The risk of atherosclerosis and venous thrombosis is increased when the total homocysteine concentration in the blood exceeds 10 μmol/L. Vitamin B12 is involved in the methylation metabolism of homocysteine and is an essential cofactor for methionine synthase (the enzyme that catalyzes homocysteine methylation). The concentration of vitamin B12 and folic acid is correlated with the concentration of homocysteine in blood. High incidence of coronary artery disease was associated with vitamin B12 deficiency in the Indian vegetarian population Chemicalbook. In diabetic retinopathy population, vitamin B12 deficiency is associated with high homocysteine, and vitamin B12 deficiency may be an independent risk factor for diabetic retinopathy. But vitamin B12 does not reduce the risk of cardiovascular disease or diabetes. - Neuropsychiatric diseases
Vitamin B12 and folic acid play a pivotal role in maintaining the normal function of the central nervous system (CNS). SAM is an important donor of methyl groups in the brain, and an imbalance of methylation is one of the causes of neurological and psychiatric diseases. Homocysteine is also one of the causes of CNS disorders and is associated with cognitive impairment. Vitamin B12 or folic acid deficiency can lead to increased homocysteine concentrations and interfere with methylation status. MMA is also toxic to the nervous system. Vitamin B12 and folic acid may have protective effects against CNS lesions, mood disorders, and dementia (including vascular dementia and Alzheimer’s disease dementia) in the elderly, and other studies have shown negative results. Despite extensive literature linking B vitamins to homocysteine, cognitive and mood disorders, and dementia, even if they reduce homocysteine levels, there is no clear evidence from randomized controlled trials that vitamin B12 supplementation Cognitive impairment and dementia were improved with folic acid, but not depressive symptoms. - Fertility and birth defects
Folic acid is a protective factor for neural tube defects (NTD), and vitamin B12, which is closely linked to folic acid metabolism, is also an independent risk factor for NTD. Vitamin B12 deficiency is also one of the risk factors for early miscarriage and recurrent miscarriage. In the neonatal period, vitamin B12 deficiency can severely impair the development and function of the nervous system, and infants are more likely to present with growth retardation and neurological deficits than anemia. Once a baby develops a vitamin B12 deficiency, the low levels of vitamin B12 will persist for at least a year. Even with early correction of vitamin B12 deficiency, these children may present with long-term neurological and cognitive impairment, including irritability, anorexia, growth retardation, developmental regression, and mental retardation. - Others
Vitamin B12 deficiency may increase the chances of developing some cancers. Vitamin B12 and bone mineral density may be related, but the conclusions of different studies are inconsistent.
Reference
- Vitamin B12 – WikiPedia
- Cyanocobalamin – PubChem
Vitamin B12 Cobalamin Supplier and Manufacturer
As a vitamin b12 cobalamin supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best vitamin b12 cobalamin raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for vitamin b12 cobalamin and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Vitamin B12 Cobalamin
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