Ubidecarenone CAS 303-98-0 Coenzyme Q10

Under the workplace culture of long-term overtime, modern people often have abnormal work schedules and lack of sleep. Without proper rest, they suffer from fatigue problems. More than 80% of them suffer from body aches, and more than 60% of them suffer from poor sleep quality.

Most temporary fatigue will be relieved after adequate rest. However, with age, the speed of metabolism and elimination of free radicals will decrease, resulting in slower recovery from fatigue.

An observational study found that fatigue and autonomic neurocognitive symptoms in patients with chronic fatigue syndrome may be related to low blood levels of coenzyme Q10 (CoQ10). Another small double-blind controlled trial (8 days in 17 healthy men) showed that higher doses of CoQ10 improved fatigue and performance after physical training. However, other randomized double-blind controlled studies (24 weeks, 236 breast cancer patients) pointed out that supplementing regular doses of CoQ10 has no effect on abnormal fatigue and decreased quality of life caused by breast cancer treatment.

Polycystic ovary syndrome is the most common endocrine disorder among women of reproductive age, with a prevalence rate of 5-21%. Patients often have symptoms such as reproductive dysfunction (hyperandrogenism, hirsutism, anovulation, infertility, menstrual disorders), metabolic system abnormalities (obesity, diabetes, and cardiovascular disease), and mood disorders. It has also been found clinically that more than half of the patients will develop hyperinsulinemia and dyslipidemia, which greatly increases the risk of cardiovascular disease.

A double-blind controlled study (60 women with polycystic ovary syndrome for 12 weeks) found that supplementation of CoQ10 (100 mg per day) helped improve blood glucose metabolism (fasting blood glucose and insulin-related values), total Cholesterol and LDL cholesterol values may have beneficial effects on patients.

Parkinson’s disease is caused by the degeneration of the nigrostriatum, which is related to the neurotransmitter: dopamine, which makes it difficult to convey the brain’s instructions, resulting in motor dysfunction, but the memory and cognitive functions of the brain can function normally. Although Parkinson’s disease does not necessarily evolve into dementia, 61% of patients will experience mental symptoms, including depression, anxiety, hallucinations and sleep disturbances. Related studies have pointed out that Parkinson’s disease patients are about 4 to 5 times more likely to lack CoQ10 than normal people. But so far, a systematic review (systematic review, including 5 randomized controlled trials, a total of 981 participants) and meta-analysis (meta-analysis) found that supplementation of Coenzyme Q10 does not bring any benefit or slow down functional degradation.

Migraine, a chronic neurological disorder, is a recurrent headache (throbbing pain on one or both sides), usually lasting 4-72 hours, and is estimated to affect about 11% of the total population. About 10–80% of migraine patients will have aura before the attack, such as blurred vision, flashes, black spots, temporary aphasia, movement disorders, etc. Although there are currently medical methods to relieve migraine (non-steroidal anti-inflammatory drugs, alkaloids, antiemetics, and serotonin receptor agonists), but the treatment is not completely effective and is often not accepted by patients. A small double-blind controlled study (for 42 migraine patients) found that taking CoQ10 (300 mg/day for 4 months, 3 times a day) can help improve the number, days, severity, and symptoms of migraine attacks , while the effective response rate (responserate) of the CoQ10 group was about 47.6%, compared with 14.4% of the placebo group. The study also concluded that CoQ10 is an effective and well-tolerated natural prescription.

Inflammation is inflammation in English, which means burning. It is a defense mechanism for the body to perform repairs in the face of foreign invaders (bacteria or viruses). The common symptoms are redness, swelling, heat, pain and itching. Almost 90% of chronic diseases are caused by chronic inflammation, including myocardial infarction, diabetes, senile dementia, cancer and other diseases, especially obesity, which is more likely to cause systemic inflammation and cause a vicious circle. In a study on coronary heart disease (coronary artery disease), it was found that taking CoQ10 (300 mg per day for 12 weeks) could increase the activity of antioxidants in the body and reduce inflammation-related hormones (such as TNF-α and IL-6 ), to control the inflammatory response.

Another study on multiple sclerosis (a neurodegenerative autoimmune disease) also found that CoQ10 can also reduce a variety of inflammatory indicators, such as TNF-α, IL-6, MMP-9, but the current anti-inflammatory The sample size of inflammation research is still too small, so more large-scale experiments are needed for further verification.

There are many reasons for skin aging and wrinkles, but free radicals from various sources are considered to be the biggest culprit. Free radicals are like fire in the body, destroying cells everywhere, which is called oxidative stress in medicine. Coenzyme Q10 has excellent anti-oxidation effect. It is found in the research that it can effectively neutralize free radicals and enhance cell vitality. It has excellent effects on preventing skin aging, reducing wrinkles and repairing collagen cells. It can be called a great supplement for the skin.

Heart failure is caused by damage to the heart muscle. It usually occurs in patients with myocardial infarction or other diseases (such as high blood pressure). Life-threatening symptoms such as dyspnea, edema, confusion and fatigue will appear. Clinically, it has been found that compared with healthy people, the cardiomyocytes of heart failure patients usually have a low Q10 concentration. Therefore, many studies have found that supplementing with coenzyme Q10 can significantly improve heart failure. The most famous of these was published by the Journal of Clinical Investigation, which concluded that patients with heart failure can improve myocardial function and reduce related complications (such as pulmonary edema) after using 2mg/kgperday of Q10.

High blood pressure is often called the invisible killer, because there are no obvious symptoms in the early stage, and it is usually not realized until the occurrence of stroke or myocardial infarction. In Western medicine, it also brings a lot of inconvenience because of the need to take medicine for life and side effects. According to a double-blind controlled study published in the journal HumanHypertension, it was found that hypertensive patients taking 120 mg of Q10 per day can effectively reduce blood pressure by 9%, while improving blood sugar levels and triglycerides.

Among the causes of male infertility, sperm quality problems account for the majority, and low sperm motility is the most common cause. Studies have found that supplementing 200 mg of Q10 daily for 6 months can increase the energy production capacity of mitochondria Efficiency, helps to improve the motility of sperm and improve the chance of conception.