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Trypsin CAS 9002-07-7

Factory Supply Trypsin CAS 9002-07-7 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Trypsin Supplier & Manufacturer

Basic Info

What is Trypsin?

Trypsin is extracted from the pancreas of cattle, pigs, and sheep, and the crystals obtained by purification are then made into freeze-dried preparations. Soluble in water, insoluble in chloroform, ethanol, ether and other organic solvents. At pH 1.8, boiling for a short time hardly inactivates it; heating in alkaline solution will cause denaturation and precipitation, Ca2+ can protect and activate, and the isoelectric point of trypsin is pH 10.1.

Trypsin is a kind of protease, EC3.4.21.4. In vertebras, characterized as a digestive enzyme. Synthesized in the pancreas as the forerunner of the enzyme trypsinogen. Secreted as a component of pancreatic juice, it is decomposed right into activated trypsin by the limitation of enterokinase or trypsin, which is an endopeptidase that can cut off the carboxyl side of lysine and also arginine residues in the polypeptide chain. It not just has the features of digestive enzymes, but also can restrict the decomposition of other forerunners of various Enzymes such as chymotrypsinogen, carboxypeptidase, as well as phospholipase, and work as an activation feature. It is one of the most particular protease, and also it comes to be a crucial device in establishing the amino acid plan of proteins.

Trypsin Uses

Trypsin belongs to the class of serine proteases and can specifically act on the carboxyl terminus of Lys or Arg residues in the peptide chain. Physiologically participate in the important processes of metabolism, digestion, blood coagulation and other functions in animals. In the field of cell biology, trypsin can degrade the protein at the junction of the cell membrane and the culture dish, so that the two can be separated. And due to the tension of the cell’s own internal cytoskeleton and the surface tension of the culture medium, it becomes spherical, thereby realizing the digestion of the cells.

Its precursor is inactive trypsinogen, which is activated in the small intestine by enterokinase or trypsin after secretion from the pancreas [3]. But the embarrassing thing is that trypsin itself is also a protein, so when it is so powerful, it even cuts itself. The original β-trypsin is converted into α-trypsin, which is further degraded into pseudotrypsin and even fragments, and its vitality gradually decreases and loses. Therefore, pancreatin faces some problems in the balance of preparation, activity and stability.

At present, trypsin products on the market mainly have two forms: freeze-dried powder and liquid. Unmodified trypsin is generally stored in a freeze-dried form and used after reconstitution, which ensures the activity of the enzyme. During use, Ca2+ has a protective and activating effect. In order to meet the needs of liquid preparations, trypsin is usually also specially treated to eliminate chymotrypsin activity and methylation or mutation to prevent self-cutting.

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This is William, CEO of Zhishang Chemical Co., Ltd.

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Application of Trypsin

Difference Between Trypsin and Pancreatin Compare the Difference Between Similar Terms

The pancreatic juice secreted by the pancreas contains trypsin, pancreatic lipase, and pancreatic amylase. The main component is trypsin, which is an endopeptidase.

The pancreas is a very inconspicuous small organ in our body—the pancreas has two parts, one is the pancreas, which is an exocrine gland that produces pancreatic juice; the other is the islets, which is an endocrine gland that produces insulin, which is secreted by the pancreas. Pancreatic juice enters the duodenum through the pancreatic duct. Pancreatic juice contains trypsin, pancreatic amylase, pancreatic lipase and other substances, which can act on the intestinal tract to break down protein, fat and sugar.

Trypsin is a proteolytic enzyme secreted by the pancreas. It acts as a digestive enzyme in animals. It mainly acts on the peptide bond at the carboxyl end of arginine or lysine. Proteins are decomposed into amino acids, amino acid polypeptides, etc. The intestinal tract is absorbed into various tissues of the human body, so trypsin plays a vital role in food digestion.

Pancreatic amylase is a hydrolytic enzyme secreted by the pancreas that acts on starch. Like the amylase secreted by the salivary gland, it belongs to α-amylase. When the food enters the mouth for chewing, the salivary amylase in the saliva digests the starch into maltose , After entering the small intestine, pancreatic amylase and intestinal amylase take over the unfinished work of salivary amylase to decompose undigested starch into maltose, and then the maltase contained in the intestinal juice decomposes into glucose under its action.

Pancrelipase, as the name implies, is an enzyme that digests fat and acts on fat. It can decompose triglycerides into fatty acids, monoglycerides and glycerol. After entering the intestinal tract, pancreatic lipase is activated into digestive enzymes that can decompose food. The fats and oils ingested by organisms can be absorbed by the intestines, which are important metabolic enzymes for the human body.

The pancreatic juice secreted by the pancreas is very important and indispensable to the human body! Let us summarize: trypsin is extracted from Dongtong pancreas through modern biotechnology, and is widely used in food processing, medicine and other fields. Trypsin is a mixture of various enzymes. Trypsin is a single enzyme. That is, trypsin is just one of the enzymes in pancreatin.

Reference

  1. “Trypsin-EDTA (0.25%)”. Stem Cell Technologies.
  2. Gudmundsdóttir A, Pálsdóttir HM (2005). “Atlantic cod trypsins: from basic research to practical applications”. Marine Biotechnology.

Trypsin Supplier and Manufacturer

As a trypsin supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best trypsin raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for trypsin and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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