
Triethylenediamine CAS 280-57-9 DETA



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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Triethylenediamine Supplier & Manufacturer
Triethylenediamine: The Complete Guide
- Item 1: Basic Info
- Item 2: What is Triethylenediamine?
- Item 3: Triethylenediamine Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Triethylenediamine
- Item 6: Preparation of Triethylenediamine
- Item 7: Quality Control of Triethylenediamine
- Item 8: Hot Sale Products
- Item 9: Get Triethylenediamine Quotation
Triethylenediamine for Sale
Basic Info of Triethylenediamine
Chemical Name: | Triethylenediamine |
Other Name: | Triethylene diamine; DETA |
CAS: | 280-57-9 |
EINECS: | 205-999-9 |
Type: | Pharmaceutical raw materials; Pharmaceuticals, pesticides, dyes, synthetic material intermediates |
Molecular Formula: | C6H12N2 |
Molecular Weight: | 112.17 |
Melting point | 156-159 °C(lit.) |
Boiling point | 174 °C |
density | 1.02 g/mL |
vapor pressure | 2.9 mm Hg ( 50 °C) |
refractive index | n20/D 1.4634(lit.) |
Fp | 198 °F |
storage temp. | Store below +30°C. |
solubility | 400g/l |
pka | 3.0, 8.7(at 25℃) |
form | Hygroscopic Crystals |
color | White to pale yellow |
Water Solubility | 46 g/100 mL (26 ºC) |
Sensitive | Hygroscopic |
Stability: | Stable, but very hygroscopic. Incompatible with strong oxidizing agents, strong acids. Highly flammable. |
Brand Name: | Zhishang Chemical |
Provide: | Triethylenediamine MSDS; Triethylenediamine COA |
What is Triethylenediamine?
Triethylenediamine, also known as 1,4-diazabicyclo[2.2.2]octane, or triethylenediamine, abbreviated as DABCO or TEDA in English, and the chemical formula is C6H12N2, is a very important chemical production It is a highly efficient catalyst and is widely used in condensation reaction, polyurethane foaming catalysis, pesticide synthesis and electroplating industries.
Triethylenediamine is a basic catalyst for polyurethane foam, an initiator for pesticide production, and an additive for chlorine-free electroplating. As one of the most widely used tertiary catalysts in the polyurethane industry, its series of products are suitable for various products such as polyurethane flexible foam, rigid foam, elastomer and coating. In my country, the traditional production process uses dichloroethane and ammonia water as raw materials, and performs hot-pressing ammonolysis at 250 °C and 3.9 MPa to generate a large amount of diethylenetriamine and a small amount of triethylenediamine. Because of the harsh process conditions , the equipment requirements are extremely high, and it has long been eliminated. Some researchers used piperazine and its derivatives as raw materials to synthesize DABCO with Ba2+-containing SrHPO4 as a catalyst in an autoclave at 360 ℃. The raw material conversion rate and DABCO selectivity were high, but the raw materials were so expensive that they only stayed in the laboratory stage. . At present, the industrial production of DABCO mostly uses ethylenediamine as the raw material. Although the production process is relatively mature, there are still problems such as shortage of raw materials, relatively expensive, and many by-products. However, ethanolamine is cheap, but has high requirements for catalyst preparation and is difficult to separate from DABCO. Studies have shown that using ZSM-5 molecular sieve as a carrier and properly supporting some metal ions, a catalyst with high catalytic activity and selectivity can be prepared.
Triethylenediamine Uses
- 1,4-diazabicyclo octane is used as polyurethane catalyst, complex ligand of Balis Hillman response catalyst and also Lewis base. It can be made use of in dye lasers and also ingrained examples for fluorescence microscopic lens. It can also be utilized as an anti fading reagent to remove free radicals created by fluorescent dyes thrilled by fluorescent dyes. Furthermore, it is an oxidation and polymerization catalyst.
- In chemical and also biological protection, activated carbon is impregnated with DABCO as well as used for mask filters, cumulative protection systems, and so on.
- Triethylenediamine is a vital chemical basic material, used as a driver for polyurethane, as well as likewise used as oil additive; used as a deterioration inhibitor in central heating boiler water therapy, and also used as a stimulant for polyurethane frothing and polymerization, epoxy resin treating Accelerator, stimulant for acrylonitrile, ethylene as well as alkoxyethylene oxide; as a non-nucleophilic base, a reagent for splitting β-ketoesters as well as geminal esters and dehydrohalogenation reactions, creating with organomagnesium, lithium, zinc compounds facilities to enhance task and participate in many reactions.
The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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Application of Triethylenediamine
Triethylenediamine has a wide range of uses, and is mainly used as a catalyst for the preparation of polyurethane foams. Its series of products can be used in various products such as polyurethane flexible foam, rigid foam, elastomer and coating, and are the most widely used and most used tertiary amine catalysts in the polyurethane industry. In addition, it acts as a petroleum additive, a catalyst for the production of polyethylene and other polyepoxy hydrocarbons. Derivatives of triethylenediamine can also be used as corrosion inhibitors and emulsifiers for anti-corrosion materials. In addition, due to its unique cage-like structure, triethylenediamine exhibits excellent catalytic performance in organic synthesis, and is widely used in polyurethane catalytic foaming, catalytic condensation and other reactions.
Since Farben developed the first generation of cast polyurethane elastomers, polyurethane has been widely used due to its unique wear resistance and mechanical properties, and has developed rapidly, with an annual growth rate of more than 4% per year. Among the catalysts for polyurethane foam, the most common and the best performing catalyst is triethylenediamine.
Triethylenediamine has a unique cage-like structure in which two nitrogen atoms are directly linked to three ethylene groups to form a bimolecular structure, which is very dense and symmetrical. Since the N atom not only has no other substituents to increase steric hindrance, but also has a pair of vacant electrons that are very accessible, in the catalytic foaming system, after the urethane bond is formed, triethylenediamine will be freed and participate in next catalytic process. Therefore, although triethylenediamine is not a strong base, it exhibits extremely high catalytic activity towards the reaction of isocyanate groups and active hydrogen compounds.
Taking triethylenediamine catalyzed poly(1,6-hexanediol carbonate) ester diol as an example, firstly, triethylenediamine interacts with 1,6-hexanediol to form hydrogen bonds on the N atom, and increase the The nucleophilicity of the alkoxy group is improved; the nitrogen atom at the other end reacts with dimethyl carbonate to cut off the carbonyl group, and then the elimination reaction is carried out to remove a molecule of methanol, the catalyst is freed for regeneration and continues to catalyze the reaction, and finally the carbon The purpose of chain growth.
In addition to the above application in polyurethane synthesis, another important application of triethylenediamine in organic synthesis is condensation reaction, including Knoevenagel condensation and Ullmann coupling condensation reaction. Triethylenediamine has shown excellent catalytic effect.
- Knoevenagel condensation: Knoevenagel condensation reaction is a classic reaction of growing carbon chains by forming carbon-carbon double bonds, usually by dehydration of carbonyl compounds (especially aldehydes and ketones) and compounds containing active methylene groups. Classic catalysts are generally acids, bases or . The advantage is that the catalyst is easy to obtain, but the reaction conditions are generally harsh, such as long reaction time, complicated post-processing, etc., so it is difficult to industrially promote or scale up. It has been reported that ionic liquids supported by triethylenediamine or triethylenediamine are currently used as catalysts for Knoevenagel condensation and good results have been achieved. The process is generally divided into two stages. The first is the preparation of ionic liquid catalysts: triethylenediamine reacts with halogen-containing compounds on the N atom to free the halogen, and then reacts with other salts (such as sodium hexafluorophosphate), etc., Improve the performance of the ionic catalyst; secondly, the ionic liquid interacts with aldehydes/ketones to form intermolecular hydrogen bonds to enhance the carbonyl carbonyl positivity. The nitrogen atom at the other end of the ionic liquid captures the active methylene hydrogen atom, and then the two are condensed, and the ionic catalyst is free. and achieve regeneration. Since the two ends of the ionic liquid have dual catalytic activity, the catalytic activity is greatly improved. The mechanism of action is as shown below:
Ullmann coupling condensation: Ullmann coupling condensation is the formation of aryl-aryl bonds and aryl-heterocycles
One of the most important methods of bonding, the commonly used catalysts for this type of reaction are salts of copper, nickel, etc., which generally require a temperature of about 200 °C, and because the catalyst is a solid catalyst with a small catalytic area, the reaction generally takes a long time. to complete. Triethylenediamine was used as a catalyst in Ullmann coupling condensation and it was successful, which provided a new way for the application of Ullmann coupling condensation. Azoxystrobin is a new type of methoxyacrylate fungicide developed by Syngenta. Due to its unique sterilization mechanism, it quickly became the largest-selling fungicide variety after it was launched, and its sales have continued to increase in recent years. The early synthesis process of this product uses potassium carbonate and copper halide as catalysts, and is prepared by high temperature reaction in polar solvent. With this process, not only the reaction time is longer, but the yield is lower. After using triethylenediamine and potassium carbonate as catalysts, the conversion rate is at least over 90%, the reaction yield is over 80%, and the reaction time is shortened to about 70 minutes. However, it was found by comparison that with triethylenediamine and sodium carbonate as catalysts, the yield was significantly reduced and the reaction time was prolonged. It can be seen that the type of base plays a very important role in the catalytic effect of triethylenediamine. In such Ullmann coupling condensation of triethylenediamine, not only the N atom interacts with the corresponding groups participating in the condensation reaction, but also can capture potassium ions through the cage structure, improve the solubility of sodium phenolate, and achieve approximately uniformity. The purpose of the opposite reaction is to shorten the reaction time. The reason for the slow catalytic reaction rate and low yield of sodium carbonate is that the radius of sodium ion is much smaller than that of potassium ion, so triethylenediamine cannot capture sodium ion firmly, and sodium phenolate has low solubility in organic dissolution, and the reaction is still heterogeneous. Instead respond. The reaction process is similar to the following:
Preparation of Triethylenediamine
- Dissolve piperazine in methanol in advance, add 123.9g (1.05mol) dimethyl oxalate to the reaction flask with mechanical stirring device, add methanol to dissolve completely, add 4.3g sodium methoxide, then take 86g (1mol) Piperazine dissolved in methanol is slowly added dropwise at a temperature of 40° C. After the dropwise addition, the mixture is stirred for 1 to 2 hours and filtered. The obtained filter cake is washed with methanol and dried to obtain an intermediate product, dioxytriethylenediamine.
- In the autoclave, add the dioxytriethylenediamine obtained in step (1), add tetrahydrofuran to dissolve completely, add 4.3g of palladium carbon, seal the lid tightly, heat up to 175° C. Fill with hydrogen until the pressure reaches 5MPa, continue to fill with hydrogen to maintain the pressure during the reaction, until the pressure no longer drops significantly, to obtain crude triethylenediamine.
- Open the exhaust valve of the autoclave to exhaust, open the lid of the autoclave, reduce to room temperature, filter the triethylenediamine crude product obtained in step (2) to remove the catalyst, add ethanol after rectifying the tetrahydrofuran, and filter, The obtained filter cake was dried to obtain 98.11 g of the final product triethylenediamine.
The molar yield of triethylenediamine was calculated to be 87.6%, and the purity of triethylenediamine detected by gas phase was 99.0%.
Reference
- 1,4-Diazabicyclo[2.2.2]octane – PubChem
- DABCO – WikiPedia
- [Chinese invention] CN202010604011.6 A kind of synthetic method of triethylenediamine
- Yang Guozhong, Guo Tingting, Chen Yinxia, et al. Synthesis and Application of Triethylenediamine [J]. Fine and Specialty Chemicals, 2015 (2): 35-38.
Triethylenediamine Supplier and Manufacturer
As a triethylenediamine supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best triethylenediamine raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for triethylenediamine and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Triethylenediamine

