Triclosan CAS 3380-34-5 TCS | Irgasan

Triclosan(also called Irgasan) is a high-efficiency broad-spectrum antibacterial disinfectant for external use. White or off-white crystalline powder with a slight phenolic odor. Insoluble in water, soluble in lye and organic solvents. Irgasan has stable chemical properties, temperature resistance, acid-base hydrolysis resistance, no toxic symptoms and no environmental pollution. Irgasan is an internationally recognized special effect fungicide variety. It can kill Staphylococcus aureus, Escherichia coli and other bacteria and Candida albicans and other fungi, also has inhibitory effect on viruses (such as hepatitis B virus, etc.), and can protect beneficial bacteria.

The sterilization mechanism of triclosan is to first adsorb on the bacterial cell wall, then penetrate the cell wall, and react with lipids and proteins in the cytoplasm, resulting in protein denaturation, and then killing bacteria. At present, it has been widely used in high-efficiency medicated soap (sanitary soap, sanitary lotion), deodorant (foot aerosol), disinfectant hand sanitizer, wound disinfectant spray, medical device disinfectant, sanitary facial cleanser (cream), air freshener and In daily chemicals such as refrigerator deodorants, Irgasan is also used in the finishing of sanitary fabrics and the antiseptic treatment of plastics. High-purity toothpastes and mouthwashes can be used to treat gingivitis, periodontitis and oral ulcers. The state stipulates that the content shall not exceed 0.3%.

As a broad-spectrum antimicrobial agent, triclosan (TCS) is widely used in textiles, medical devices, children’s toys, and many personal care products such as toothpaste, soap, and facial cleansers. Triclosan has estrogenic effects and high lipophilicity, and can be absorbed into the body through the skin, oral mucosa and gastrointestinal tract. Triclosan residues have been identified in human blood, urine, breast milk, amniotic fluid, adipose tissue, liver and brain. In 2016, the FDA banned the addition of triclosan in hand sanitizers and body washes.