Triclocarban CAS 101-20-2 TCC
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Factory Supply Triclocarban CAS 101-20-2 TCC with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Triclocarban Supplier & Manufacturer
Triclocarban: The Complete Guide
Triclocarban for Sale
Basic Info
Basic Info
| Chemical Name: | Triclocarban |
| Other Name: | 3,4,4′-Trichlorocarbanilide; TCC |
| CAS: | 101-20-2 |
| EINECS: | 202-924-1 |
| Type: | Additives; Pharmaceutical raw materials; Organic raw materials; Organic intermediate |
| Molecular Formula: | C13H9Cl3N2O |
| Molecular Weight: | 315.58 |
Chemical Properties
Melting point | 254-256 °C (lit.) |
Boiling point | 344.2±42.0 °C(Predicted) |
density | 1.5732 (rough estimate) |
vapor pressure | <0.1 mm Hg ( 25 °C) |
refractive index | 1.6300 (estimate) |
Fp | 150 °C |
storage temp. | Sealed in dry,Room Temperature |
solubility | methanol: soluble |
form | neat |
pka | 12.77±0.70(Predicted) |
color | Fine plates |
Water Solubility | <0.1 g/100 mL at 26 ºC |
Merck | 14,9654 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents strong bases. |
Other Info
| Brand Name: | Zhishang Chemical |
| Provide: | Triclocarban MSDS; Triclocarban COA |
What is Triclocarban?
Triclosan (TCS), scientific name “dichlorophenoxychlorophene”, also known as Irgacare MP, IrgasanDP-300, etc., its normal state is white or off-white crystalline powder, slightly soluble in water, moderate solubility in dilute alkali, in It has high solubility in many organic solvents. As a broad-spectrum antibacterial agent, triclosan is widely used in daily chemicals such as hand sanitizer, bath soap, body wash, cosmetic powder and concealer, nail cleaner, toothpaste, etc. It can be made into a transparent concentrated liquid product after dissolving in a water-soluble solvent or surfactant.
In addition, triclosan has stability, low toxicity, high stability to strong acids, strong alkalis and heat, non-irritating to the skin and resistance to infection-causing or pathogenic Gram-positive bacteria, fungi, yeast and viruses (such as A , hepatitis B, rabies virus, HIV (HTV), etc. have a wide range of killing and inhibition.
Similar to triclosan, triclocarban (TCC) also has good compatibility with the skin, and has a highly effective inhibitory effect on gram-positive bacteria, gram-negative bacteria, fungi, yeast and viruses.
Triclocarban is also found in everyday products. Its bactericidal mechanism is as follows: Triclocarban penetrates the cell membrane and destroys the enzymes on which microorganisms depend for survival, thereby eliminating bacteria, viruses, fungi and other microorganisms. However, this enzyme is unique to microorganisms and is different from the enzymes in the human body. Therefore, when triclocarban exerts its antibacterial effect, it will not directly have adverse effects on the human body.
Triclocarban Uses
3,4,4 ‘- Trichlorocarbanilide will interfere with mammalian reproduction and may lead to methemoglobinemia in humans.
Trichlorocarban is utilized as a bacteriostatic and also chemical in soap as well as other cleaning structures. Chemicals as well as disinfectants are widely used in washing powder, soap, shower gel, etc.
Antimicrobial agents for day-to-day chemicals. It has the attributes of continuous, risk-free and also stable sanitation, exceptional compatibility with the skin, and also effective restraint as well as murder effect on gram-positive bacteria, gram-negative bacteria, fungis, yeast and viruses.
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This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
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If you want to buy triclocarban, pls contact us to get a free quote.
Application of Triclocarban
Bacteria
Trichlorocarban is mainly active against gram-positive bacteria (bacteria with thick peptidoglycan wall). The exact mechanism of action of triclosan is unclear, but it has been proved that it has bacteriostatic effect and can prevent bacterial proliferation.- Human beings
Like bacteria, the specific mechanism of the effect of triclosan on human health is unclear. In general, triclosan can enhance gene expression of other steroid hormones, including androgen, estrogen and cortisol. It is speculated that the function of this compound is similar to the cofactor or co-activator that regulates the activity of estrogen receptor and androgen receptor. Experiments show that triclosan can activate the constitutive androgen receptor and estrogen receptor in vivo and in vitro α It may also change the normal physiological homeostasis. The activation of these receptors will amplify gene expression, which may be the mechanism basis of the effect of triclosan on human health. However, further research is needed to determine whether triclosan can increase the activity of sex steroid hormones by binding to receptors or by binding to receptor coactivators and making them sensitive.
Others
Antibacterial residential properties
Trichocarban is utilized to treat first microbial skin as well as mucosal infections and those with the danger of repeated infection. In vitro, triclosan has been discovered to be reliable versus a variety of Staphylococcus, Streptococcus and Enterococcus strains. Also at extremely reduced levels, it has actually confirmed to be an effective antibacterial agent. It has actually been discovered that the minimal repressive focus of trichlorocarban on these different pressures varies from 0.5 to 8 mg/L. There is no question that triclosan only has antibacterial impact on gram-positive bacteria such as Staphylococcus aureus, which suggests that the anti-bacterial task device of triclosan is via its destruction of the stability of bacterial cell wall.
Resistance
Direct exposure of organisms such as fish, algae as well as human beings to low levels of triclosan and also other antibacterial chemicals will certainly kill weak microorganisms and also enable a lot more resistant strains to multiply. Since microorganisms share genes, the rise of resistant pressures boosts the possibility of weak microbes obtaining these immune genes. Consequently, brand-new drug-resistant microbial nests were generated.
When drug-resistant microbes are subjected to antimicrobial representatives, they will certainly enhance the expression of the genes that provide this resistance. The danger of microbial antibiotic resistance was examined by quantitatively monitoring the wealth of tetQ genetics in the microcosm of wastewater. Because tetQ is the most usual resistance genetics in the environment and inscribes ribosomal protective protein, the amount of its expression is related to the amount of resistance in the microbial population. The enhancement of triclosan raised the expression of the tetQ gene.
When a selection of anti-bacterial representatives (such as tetracycline, triclosan and also triclosan) were added to the speculative system at the same time, it was likewise found that the expression of TetQ gene in bacteria was significantly enhanced. Combining these compounds with each other will result in usual option of resistance genetics (or natural selection via more than one reagent), hence impacting resistance. The intricacy of microbial areas and also the visibility of a lot of anti-biotics in the aquatic setting frequently result in this vibrant option event and the multi-drug resistance pattern in naturally happening microorganisms.
Reference
- Triclocarban – WikiPedia
- Orsi Mario; Noro Massimo; Essex Jonathan (2010). “Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes”. Journal of the Royal Society Interface.
Triclocarban Supplier and Manufacturer
As a triclocarban supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best triclocarban raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for triclocarban and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Shipping
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Triclocarban
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