Tranylcypromine Hemisulfate CAS 13492-01-8
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
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Tranylcypromine Hemisulfate: The Complete Guide
Tranylcypromine Hemisulfate for Sale
trans-2-PhenylcyclopropylaMine HeMisulfate; Tranylcypromine (hemisulfate); DTNB
Pharmaceutical raw materials
What is Tranylcypromine Hemisulfate?
Tranylcypromine sulfonate, (±) – trans-2-phenylcyclopropylaminesulfat (Parnate) is synthesized into amphetamine analogues (visual amphetamine α- Methyl condensation to β- Carbon atom). It does have some characteristics similar to amphetamine, which may be why it has a more direct CNS excitatory effect than drugs that inhibit MAO alone. For MAO inhibition, the effect of the drug may have two components. One is believed to be due to the proximity β- Structural characteristics of transition states in arylamine metabolic pathway (basic nitrogen and α- And β- Quasi π characteristics of cyclopropane carbon atoms). When α- And β- When the hydrogen atom is removed from the normal substrate of the enzyme, the quasi π feature is α,β- Carbon system development. The repetition of the transition state allows very strong, but reversible, attachment to the enzyme.
In addition, trans amphetamine is a mechanism based inactivator. It is metabolized by MAO and one electron of the nitrogen pair is lost to flavin. In turn, this will result in homogeneous fission of cyclopropane carbon bond, in which one electron pairs with the remaining lone nitrogen electrons to form imine (protonation), and the other is located on methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes. One electron from fission pairs with the remaining lone nitrogen electrons to produce imine (protonation), and the other electron is located on the methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes. One electron from fission pairs with the remaining lone nitrogen electrons to produce imine (protonation), and the other electron is located on the methylene carbon. Therefore, free radicals are formed, which react to form covalent bonds with enzymes or reducing flavins to inactivate enzymes.
Tranylcypromine Hemisulfate Uses
- Amphetamine developed by side chain cyclization of amphetamine. This monoamine oxidase inhibitor can efficiently treat severe depression, dysthymia as well as irregular depression. It can additionally be used for panic and also fear.
- Tramcyclopropylamine (13492-01-8) is a permanent and also non discerning monoamine oxidase inhibitor. It has been confirmed to hinder histone demethylase.
- Tranylcypromine (Parnate) is an irreversible monoamine oxidase (MAO) inhibitor.
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Application of Tranylcypromine Hemisulfate
Tranylcypromine (10nM to 10 µ M) for human A β (1-42) Oligomer generated toxicity has neuroprotective result and is not affected by glial cells. Tranylcypromine( 100 μ M) It dramatically protects RGC from apoptosis generated by glutamate neurotoxicity as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen activated protein kinase 12 (p38MAPK) under glutamate caused anxiety γ) Expression of. In addition, trans amphetamine can transform p38MAPK γ Task advertises RGC survival.
Preparation of Tranylcypromine Hemisulfate
Amazing the option having 167 g of stable styrene and 183 g of ethyl diazoacetate to 0 ° C, and decline 83.5 g of styrene under mixing at 125 ° to 135 ° C in a dry nitrogen ambience. This provides the ester ethyl 2-phenylcyclopropane carboxylate.
Reflux the above ester (207.8 g) and also 64.5 g sodium hydroxide solution in 80 ml water and also 600 ml ethanol for 9 hrs. The carboxylic acid of 2-phenylcyclopropane is launched by 200cc focused hydrochloric acid. 2-Phenylcyclopropane carboxylic acid has 3-4 trans isomers as well as 1 cis isomer. Acid recrystallizes from hot water. Pure trans isomers take place as crystalline compounds (solids), while cis isomers continue to be in solution. 4.62 g of 2-phenylcyclopropane carboxylic acid solution in 15 cc of anhydrous benzene was refluxed with 4 cc of thionyl chloride for 5 hours to eliminate unpredictable liquid, and also the residue was distilled with benzene again. Fractionation of the residue returns carbonyl chloride of 2-phenylcyclopropane.
A mixture of 15 g of industrial salt azide and also 50 ml of anhydrous toluene was stirred and warmed, and then 10 g of 2-phenylcyclopropane carbonyl chloride option in 50 ml of anhydrous toluene was slowly included. Filter the inorganic salt as well as clean it completely with anhydrous benzene to remove the solvent under lowered stress. The resulting RCON3 compound was repositioned into RNCO+N 2 with Curtius. The residual isocyanate is a clear red oily substance with particular odor. It was cooled to 10 ° C and also thoroughly treated with 100 cc of 35% hydrochloric acid, where RNCO+H 2O generated RNH2+CO2. After most of the launch of co2 has actually decreased, the mixture is refluxed for 13 hrs, the cooled solution is diluted with 75 cc of water and removed with three 50 cc parts of ether.
Awesome the virtually completely dry residue to 0 ° C as well as adjust it to solid alkalinity with 50% potassium hydroxide remedy. Remove amine right into numerous sections of ether, dry with potassium hydroxide, remove solvent, and also fractionate alkali. Alkali reacts with half a mole of sulfuric acid to form sulfate.
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