Tetramethylguanidine CAS 80-70-6

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  • Appearance: Colorless liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Tetramethylguanidine Supplier & Manufacturer

Basic Info

What is Tetramethylguanidine?

Tetramethylguanidine is a colorless oily liquid with a boiling point of 160-162°C, a density of 0.918, and a refractive index of 1.4692. It is an organic strong base, soluble in toluene, cyclohexanone, ethanol, etc., and also soluble in water. In alkaline aqueous solution It is easily hydrolyzed into tetramethylurea, which is corrosive, and is usually packed in galvanized iron drums.

Tetramethylguanidine is abbreviated as TMG, which is a natural base driver and a solvent for the synthesis of new antibiotic cephalosporins. At the same time, it can be utilized as a stimulus for polyurethane foam and also for degree drying of nylon , wool and also various other healthy proteins to improve the longevity of woollen. At present, it is mainly made use of in the synthesis of drugs such as cephradine. In the past, 1,5-dichloroheterobicyclo [4,3,0] nonene-5 (DBU for short) was mostly utilized as a cosolvent for the synthesis of brand-new antibiotic cephalosporins. Considering that the process path utilizing tetramethylguanidine as a coagent can To minimize raw material costs and boost product top quality and also return, an increasing number of producers make use of tetramethylguanidine as a complementary representative in the synthesis of antibiotic cephalosporins.

Tetramethylguanidine Uses

  1. In organic synthesis, 1,1,3,3-tetramethylguanidine is used as a strong, non-nucleophilic base. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation of alcohols.
  2. Tetramethylguanidine can be used as an organic base catalyst and a cosolvent for the synthesis of new antibiotic cephalosporins.
  3. Tetramethylguanidine can be used as a catalyst for polyurethane foam and for level dyeing of nylon, wool and other proteins to improve the durability of wool, etc.
  4. Tetramethylguanidine is widely used in the synthesis of pharmaceutical and chemical raw materials. In medicine, it is mainly used in the production of cephalosporin antibiotics.

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Application of Tetramethylguanidine

1,1,3,3-Tetramethylguanidine is an important intermediate in organic synthesis, which is expensive and can be used as a catalyst for polyurethane foam, as well as for the production of nylon (nylon), wool and other proteins. Level dyeing, used in the synthesis of cephalosporin series antibiotics in the pharmaceutical industry. Its application examples are as follows:

  • Prepare ZSM-5 zeolite, under neutral conditions, use tetramethylguanidine as template to synthesize ZSM-5 zeolite. The preparation method comprises the following steps: a. mixing template tetramethylguanidine with deionized water, ammonium fluoride, and alumina source; b. adding acid to adjust pH to neutral; c. adding silicon source; d. crystallizing Chemical, synthetic ZSM-5 zeolite molecular sieve. Because the industrial application of zeolite molecular sieves must consider the cost of obtaining molecular sieves, this is a reason why they cannot be widely used. In the prior art, the organic templates and inorganic materials required for the synthesis of ZSM-5 are relatively expensive. The present invention adopts low-cost The templating agent tetramethylguanidine is of great significance for the industrial application of zeolite molecular sieves. In addition, usually ZSM-5 needs to be synthesized under strong alkaline conditions, but the present invention successfully synthesized ZSM-5 zeolite with higher crystallinity under neutral conditions for the first time.
  • Prepare a polyguanidine-based ionic liquid material for phosphopeptide enrichment, the steps are as follows: add 1,1,3,3-tetramethylguanidine and vinyl-containing halogen monomers to the acetonitrile solution, and react at room temperature , and dry to obtain the functional monomer of guanidine-based ionic liquid; the functional monomer, crosslinking agent and initiator are dissolved in acetonitrile to obtain a mixed solution, and nitrogen gas is passed into the mixed solution to remove oxygen; polymerization is initiated under a water bath, and the The solid material is washed with distilled water, suction filtered, and dried to obtain the polyguanidine-based ionic liquid material for phosphopeptide enrichment. The guanidine-based polyionic liquid material prepared by this method has good biocompatibility, good dispersibility, uniform material particle size, strong adsorption performance for phosphopeptides, high enrichment efficiency for phosphopeptides, stable performance, and can realize It can be reused at least five times, and it can still be used for the enrichment of phosphopeptides after being placed in a dry environment at room temperature for one year, which greatly saves the production cost of use and has broad application prospects.

Preparation of Tetramethylguanidine


  • 1,1,3,3-Tetramethylguanidine – WikiPedia
  • CN02143846. intermediate- hydrochloride preparation method comparison of tetramethylguanidine synthesis process

Tetramethylguanidine Supplier and Manufacturer

As a tetramethylguanidine supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best tetramethylguanidine raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for tetramethylguanidine and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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