Tetrabutylammonium Bromide CAS 1643-19-2

Factory Supply Tetrabutylammonium Bromide CAS 1643-19-2 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Tetrabutylammonium Bromide Supplier & Manufacturer

Basic Info

What is Tetrabutylammonium Bromide?

Tetrabutylammonium bromide, a common chemical product on the market, is an ion-pairing reagent and an effective phase transfer catalyst. It is used in the preparation of many other tetrabutylammonium salts by salt double decay reactions. Anhydrous seeds are white solids.

As an organic chemical phase transfer catalyst, tetrabutylammonium bromide is used in the synthesis of pharmaceutical intermediates such as benzyltriethylammonium chloride, ethyl cinnamate, pseudoionone, etc. It is also used in the anti-infective drug bamcillin In the synthesis of organic drugs such as sutacillin and sutacillin, tetrabutylammonium bromide is also used as a catalyst in the synthesis of antidiabetic drugs such as dapagliflozin with a new mechanism of action.

Tetrabutylammonium Bromide Uses

  1. Tetrabutylammonium bromide is used as phase transfer catalyst; polarographic analysis reagent; ion-pair chromatography reagent.
  2. Lon pair chromatography reagent, phase transfer catalyst. The synthesis of baminocillin, sutacillin, etc.
  3. Tetrabutylammonium bromide is used for the synthesis of 3-phenylacrolein, benzyl cinnamate and other chemicals. Tetrabutylammonium bromide can also be used in the electrochemical bromination of aromatic compounds.
  4. Tetrabutylammonium bromide is made use of to prepare various other salts of tetrabutylammonium cations by salt double disintegration reaction.
  5. Tetrabutylammonium bromide is made use of as a resource of bromine ions for alternative reactions. It is one of the typically made use of phase transfer catalysts. Because its melting point simply goes beyond 100 ° C as well as will certainly lower in the existence of other reagents, it can be considered an ionic fluid.

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Application of Tetrabutylammonium Bromide

Preparation of Tetrabutylammonium Bromide

  1. Synthetic reaction of tetrabutylammonium bromide
    In a 1000-milliliter reactor with heating device, electric stirring, thermometer, and water circulation condenser, put 200 g of tri-n-butylamine, 200 g of bromobutane, 200 g of solvent acetonitrile, stir and heat to slow reflux, constant temperature Reaction for 22-24 hours.
  2. Make tetrabutylammonium bromide crude product
    The mixture obtained after the reaction was distilled at atmospheric pressure, acetonitrile and excess bromobutane were recovered, heated to 100° C., and the remaining acetonitrile and bromobutane were removed under reduced pressure, and the resulting pale yellow transparent liquid was the crude tetrabutylammonium bromide.
  3. Refined
    150 g of ethyl acetate was added to the crude tetrabutylammonium bromide, heated to reflux and kept for 0.5 hours, then crystallized by cooling, filtered, and the product was decompressed at 50°C, and the vacuum was maintained at 30-35mmHg column to remove residual ethyl acetate, the obtained white crystal is the finished product of tetrabutylammonium bromide.


  1. Tetrabutylammonium Bromide – PubChem
  2. [Chinese invention] CN200910070539.3 A kind of preparation method of tetrabutylammonium bromide
  3. Henry J. Ledon (1988). “Diazo transfer by means of phase-transfer catalysis: di-tert-butyl diazomalonate”Organic Syntheses.Collective Volume, vol. 6, p. 414

Tetrabutylammonium Bromide Supplier and Manufacturer

As a tetrabutylammonium bromide supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best tetrabutylammonium bromide raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have demand for tetrabutylammonium bromide and related products, please contact our service staff Zhishang Chemical – White directly, we will provide you with high-quality products at the best price.

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