Tetrabutylammonium Bromide CAS 1643-19-2

CN201410203463.8 discloses a method for detecting minodronic acid using high performance liquid chromatography, which includes the following chromatographic conditions:

The mobile phase is a mixed solution of an aqueous solution containing sodium pyrophosphate and tetrabutylammonium bromide and methanol with a volume ratio of 90:10 to 100:0, and the pH of the aqueous solution is 7.0 to 8.0, wherein the concentration of sodium pyrophosphate The concentration of tetrabutylammonium bromide is 0.02~0.04mol/L, and the concentration of tetrabutylammonium bromide is 0.272~0.322g/L; the column used is octadecylsilane-bonded silica gel as filler, and the flow rate of high performance liquid chromatography is 0.8-1.2 ml/min, the detection wavelength is 218~282nm, and the injection volume is 5~50μl.

Using the detection method provided by the present invention, the separation degree of the main peak and the adjacent impurity peaks in the test sample and the raw material are all greater than 1.5, the column efficiency of the main peak is all greater than 3000, the tailing factor is good, and the system applicability is good.

CN201110345118.4 discloses a highly selective synthesis method of benzoylformic acid, which is mainly used to prepare intermediate raw materials such as medicines and pesticides. In recent years, by complexing with metal elements, it has been found that it can be used as a sensitizer for fluorescent materials and a catalyst for organic oxidation reactions, which has attracted more attention.

The method is as follows, using styrene as a raw material, in a mixed system of H2O2 and tetrabutylammonium bromide through addition oxidation reaction to obtain α-bromoacetophenone; then adding ethylene glycol and p-toluenesulfonic acid, and refluxing reaction to generate α-bromoacetophenone Acetophenone ethylene ketal; the resulting α-bromoacetophenone ethylene ketal is hydrolyzed in potassium carbonate solution to generate α-hydroxyacetophenone ethylene ketal; α-hydroxyacetophenone ethylene ketal is dissolved in H2O2 2-phenyl-1,3-dioxolane-2-carboxylic acid is obtained by reacting with tetrabutylammonium bromide in a mixed system, which is then deprotected with oxalic acid to generate the target product benzoylformic acid.

The preparation method of the invention has high reaction yield, good reaction selectivity, low cost, simple process, mild reaction conditions, high product purity, avoids serious environmental pollution and high cost of the traditional process, and is a large-scale industrial production method. prospect method.