
Terpinen-4-ol CAS 562-74-3



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- Appearance: Colorless liquid
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Terpinen-4-ol Supplier & Manufacturer
Terpinen-4-ol: The Complete Guide
Terpinen-4-ol for Sale
Basic Info of Terpinen-4-ol
Chemical Name: | Terpinen-4-ol |
Other Name: | 4-Carvomenthenol; (±)-Terpinen-4-ol; 1-isopropyl-4-methyl-cyclohex-3-enol; 1-Methyl-4-isopropyl-1-cyclohexen-4-ol |
CAS: | 562-74-3 |
EINECS: | 209-235-5 |
Type: | Food additives; Pharmaceutical raw materials; Organic raw materials; Flavors and Fragrances; Plant Extracts; Daily Chemicals |
Molecular Formula: | C10H18O |
Molecular Weight: | 154.25 |
Melting point | 137-188 °C |
alpha | +25.2° |
Boiling point | 88-90 °C |
density | 0.931 g/mL at 25 |
refractive index | n20/D 1.478 |
Fp | 175 °F |
storage temp. | -20°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Liquid |
pka | 14.94±0.40(Predicted) |
Specific Gravity | 0.930.9265 (19℃) |
color | Clear colorless to slightly yellow |
optical activity | [α]20/D 27°, neat |
Water Solubility | Very slightly soluble |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
Brand Name: | Zhishang Chemical |
Provide: | Terpinen-4-ol MSDS; Terpinen-4-ol COA |
What is Terpinen-4-ol?
It has been located that the vital oil and its elements drawn out from plant materials have antimicrobial, antiviral, antifungal, antioxidant, anti-inflammatory and also anti-cancer activities. Monoterpenes are the significant plant acquired second metabolites extensively found in natural products, consisting of fruits, veggies and herbs, and also are known to be connected to plant defense reaction. Monoterpenes are made up of 2 isoprene units and also are located in large quantities in necessary oils. In addition, lots of monoterpenes have been proposed to exert effective anticancer activities. It is reported that several of them have actually revealed rewarding lead to the prevention as well as therapy of various sorts of leukemia as well as cancer cells, such as breast cancer, skin cancer, pancreatic cancer and colon cancer in rats. It is notable that numerous of these substances, including Perilla Alcohol as well as limonene, are being tested in recurring human researches.
Terpinen-4-ol is just one of the main energetic ingredients of tea tree oil (TTO), which is made up of mixes of more than 100 various compounds and also exists in a variety of aromatic plants (orange, citrus, oregano, New Zealand lemon tree, Japanese cedar as well as black pepper).
Terpinen-4-ol is an effective fungicide with antifungal residential properties. Of certain interest is the artificial insemination activity against Staphylococcus aureus as well as Candida fungus albicans The results reveal that the combination of this natural material as well as conventional medicines may be practical in the therapy of drug-resistant yeast as well as bacterial infections.
Several current reports have actually shown that terpinen-4-ol induces antitumor results by uniquely causing necrotic cell death as well as cell cycle arrest in melanoma cell lines, or by activating caspase dependent apoptosis in human melanoma cells, particularly in drug (doxorubicin) – immune cells. In addition, terpinen-4-ol has actually been shown to trigger a dose-dependent cytotoxic feedback to human non-small cell lung cancer cells, possibly by participating in the mitochondrial apoptosis pathway.
Terpinen-4-ol Uses
- Terpinen-4-ol is a naturally occurring monoterpene, the major active component of tea tree oil, with different biological tasks such as antifungal activity.
- Reference Standards in the Analysis of Herbal Products.
- Terpinen-4-ol is used as an ingredient in skin care lotion and body wash; as a food additive such as mint ingredients; an intermediate for antibacterial agents; an intermediate for preservatives; a fragrance ingredient for rose oil and geranium oil formulations.
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Application of Terpinen-4-ol
Terpinen-4-ol had in tto enhances it with various organic effects. Terpinen-4-ol is the primary energetic component of tea tree oil. Terpinen-4-ol has attracted attention as a result of its antibacterial, antifungal, antiviral as well as anti-inflammatory properties.
Erpinen-4-ol had in tto grants it with considerable antibacterial activity The majority of microorganisms are sensitive to tto at a concentration of 1.0% or much less; It has actually been reported that the MIC of microbes such as commensal Staphylococcus and also Micrococcus, Enterococcus faecalis as well as Pseudomonas aeruginosa goes beyond 2%. Tto is mainly antiseptic in nature, although it may be bacteriostatic at lower concentrations. The task of tto on antibiotic resistant germs has aroused substantial passion, and so far, methicillin-resistant Staphylococcus aureus (MRSA) has obtained the most focus.
Considering that the potential of using tto versus MRSA was first hypothesized, numerous groups have examined the task of tto against MRSA starting from Carson et al. He examined 64 MRSA isolates from Australia and the UK, consisting of 33 mupirocin resistant pressures. When checking out the result of terpinen-4-ol on Staphylococcus aureus, it was not found that it would certainly induce autolysis, but it would certainly result in the leakage of 260 nm light soaking up product as well as make the cells sensitive to sodium chloride Electron microscopy of terpinen-4-ol-treated S. aureus cells revealed damages comparable to that seen after tto therapy, consisting of intermediate like structures. Finally, the loss of intracellular substances, failure to keep homeostasis and also respiratory system inhibition after therapy with terpene-4-ol are consistent with the systems of activity involving membrane integrity as well as loss of feature.
Two magazines suggest that tto has antiprotogenic task At concentrations of 403 mg/ ml and also 0.5 mg/ ml, tto resulted in a 50% decrease in the development of protozoa Leishmania and Trypanosoma brucei (compared to the control). In another research study, 300 mg/ ml tto eliminated all cells of Trichomonas vaginalis. There is likewise unscientific in vivo proof that tto might be effective in treating Trichomonas vaginalis infection. More examination revealed that terpinen-4-ol added considerably to this activity.
Anti mite activity.
It has actually been reported that eyelid scrub with various concentrations of tto can successfully reduce the variety of Demodex as well as ocular surface area swelling associated with blepharitis, conjunctivitis and also keratitis. Terpinen-4-ol is the most effective part in tto to eliminate Demodex.
Numerous current research studies currently support unscientific proof associating anti-inflammatory task to tto. In vitro researches in the past decade have shown that tto affects a collection of immune responses in vitro and in vivo. It can prevent lipopolysaccharide caused manufacturing of inflammatory arbitrator lump death element by human peripheral blood mononuclear cells α ( TNF- α ) 、 Interleukin 1 β ( IL-1 β ) And also IL-10 and also prostaglandin E2. Terpinen-4-ol plays a significant duty in the anti-inflammatory effect of tto. Terpinen-4-ol can lower the manufacturing of TNF by lipopolysaccharide triggered monocytes- α 、 IL-1 β 、 IL-8, IL-10 and prostaglandin E2. Terpinen-4-ol additionally prevented superoxide manufacturing by agonist promoted monocytes yet not neutrophils Tto fell short to inhibit the expression of TNF- α Excitement induced attachment of neutrophils or casein caused employment of neutrophils to the abdominal cavity of mice.
These studies determined details systems whereby tto might play a role in vivo to minimize the normal inflammatory feedback. In vivo, topically applied tto has actually been revealed to regulate edema associated with the efferent phase of call hypersensitivity in mice, however not the development of edema in the skin of non animated computer mice or the edema feedback to UVB direct exposure. This task is primarily attributed to terpinene-4-ol. Tto and terpene-4-ol applied after histamine injection decreased histamine induced skin edema, as well as tto also dramatically reduced swelling caused by intradermal injection of substance 48/ 80. Current work shows that terpinen-4-ol can manage vasodilation and also plasma extravasation connected with histamine caused human inflammation.
The anticancer result of terpene-4-ol is impressive in numerous cancer cells in vitro and also in vivo. Terpinen-4-ol is the primary component of important oils originated from several fragrant plants. It is used as an anti-inflammatory agent as well as antioxidant The duty of terpene-4-ol as an anticancer representative as well as the prospective signaling pathways for various kinds of cell death are still uncertain. Here, it is shown that the device of activity of terpene-4-ol is to generate apoptosis rather than death.
Terpene-4-ol as well as different anticancer agents were also revealed to exhibit synergistic development restraint by lowering the survival price of various cancer cell lines. Considering that reduced medicine concentrations can be made use of to treat a vast array of cancers, such mixes might be more efficient as well as less harmful. Intratumoral injection of terpene-4-ol can considerably inhibit lump growth without noticeable adverse responses.
Reference
Terpinen-4-ol Supplier and Manufacturer
As a terpinen-4-ol supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best terpinen-4-ol raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for terpinen-4-ol and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Terpinen-4-ol

