Sodium Triacetoxyborohydride CAS 56553-60-7
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Sodium Triacetoxyborohydride Supplier & Manufacturer
Sodium Triacetoxyborohydride: The Complete Guide
Sodium Triacetoxyborohydride for Sale
Pharmaceutical intermediates; Pharmaceutical raw materials; Organic raw materials
What is Sodium Triacetoxyborohydride?
Sodium triacetoxyborohydride (STAB-H) is a hygroscopic white powder with a melting point of 116-120 ° C. Soluble in benzene. It is prepared by responding NaBH4 with excess acetic acid in benzene or toluene.
Sodium triacetoxyborohydride has outstanding universality and also selectivity, mild reaction conditions, great catalytic reduction performance, as well as very easy separation as well as purification., the catalyst itself as well as by-products are safe, and have no air pollution to the setting, making it the favored driver for reductive amination.
Sodium triacetoxyborohydride is a selective decreasing agent in organic synthesis. It is specifically ideal for reductive amination. Given that the response rate of imide ion reduction is much faster than that of ketones as well as even aldehydes, reductive amination can be performed as a one-pot procedure by introducing a decreasing agent into the mix of amine and carbonyl compound. Under these conditions, the visibility of acetic acid in a stoichiometric total up to militarize imine development and offer imide ions does absent any type of problems.
Sodium Triacetoxyborohydride Uses
Sodium triacetoxyborohydride (STAB) is a hydride reagent made use of for stereoselective reductive amination. For the most part, it can replace the poisonous sodium cyanobohydride. It uniquely reduces aldehydes to alcohols in the presence of ketones. STAB is likewise stable in anhydrous acid, which can decrease and aminate aldehyde as well as ketone. It is used for reductive amination of ketones as well as aldehydes and reductive amination/internal amidation of carbonyl compounds and amines. Compared with sodium cyanobohydride, STAB has apparent advantages. STAB is non-toxic, simple to deal with, as well as does not generate hazardous by-products, making the procedure waste therapy after reaction simple and also affordable.
The new driver made use of for reductive amination has exceptional universality and also selectivity, mild reaction problems, great catalytic reduction performance, easy splitting up and filtration, non-toxic catalyst itself and spin-offs, no contamination to the atmosphere, and also becomes the preferred catalyst for reductive amination.
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Application of Sodium Triacetoxyborohydride
Sodium triacetoxyborohydride is a moderate reagent with impressive selectivity as a minimizing agent. It can minimize aldehydes instead of ketones; However, β- Hydroxyl ketones can be selectively minimized to 1,3-transdiol. The steric limitation as well as electron absorption of the 3 acetyloxy teams stabilize the boron hydrogen bond and make it mildly reducible.
Sodium triacetoxyborohydride or [NaBH (OAc) 3] can be made use of as a reagent:
- In reductive amination of ketones as well as aldehydes.
- Preparation of N-benzyl by reductive amination/internal amidation of 4-oxovalurate methyl ester and also benzylamine- γ- Pentolactam.
- The imines as well as enamines are reduced to matching amines.
- The quinoline and isoquinoline are minimized to matching tetrahydro by-products.
- In the borohydride of olefins.
- Synthesis of nitroxy extreme biradicals to create very loosened up incurable groups connected to dendrimers.
Sodium Triacetoxyborohydride Suppliers and Manufacturers
As a sodium triacetoxyborohydride supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best sodium triacetoxyborohydride raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
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