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Sodium L-ascorbyl-2-phosphate CAS 66170-10-3

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Sodium L-ascorbyl-2-phosphate Supplier & Manufacturer

Basic Info

What is Sodium L-ascorbyl-2-phosphate?

Sodium L-ascorbyl-2-phosphate Chinese alias vitamin C sodium ascorbyl phosphate, SAP, L-ascorbic acid-2-phosphate sodium salt. L-ascorbic acid-2-phosphate trisodium salt can be utilized as intermediate in pharmaceutical and also chemical synthesis.

2-Phospho-L-ascorbic acid trisodium salt functions as an antioxidant as well as a stimulator of hepatocyte development aspect (HGF) production. In vitro studies 2-phospho-L-ascorbic acid (Asc2-P) acts as an antioxidant as well as a stimulant of hepatocyte development factor (HGF) production. 2-Phospho-L-ascorbic acid is a secure by-product of L-ascorbic acid (AA) with similar biological residential or commercial properties to AA. AA as well as Asc-2P control several organic procedures. When 2-phospho-L-ascorbic acid was combined with DHT, DHT-induced DKK-1 mRNA expression in DPC was dramatically undermined. DHT therapy was additionally found to boost DKK-1 promoter task. When 2-phospho-L-ascorbic acid was combined with DHT, DHT-induced activation of luciferase task was substantially inhibited.

If breathed in L-ascorbic acid-2-phosphate trisodium salt, move individual to fresh air; in case of skin contact, remove polluted clothing, rinse skin completely with soap as well as water, seek clinical focus if discomfort occurs; In case of contact with eyes, different eyelids, rinse with running water or normal saline, as well as seek clinical focus right away; if ingested, wash mouth immediately, do not cause throwing up, and also seek clinical attention quickly.

Sodium L-ascorbyl-2-phosphate Uses

This product is used as a scientific research study reagent, and also is extensively made use of in molecular biology, pharmacology as well as various other clinical research. It is strictly restricted to be made use of in the body.

  • L-Ascorbic acid-2-phosphate (AA2P) is made use of for biocatalytic dephosphorylation for power generation as well as electrochemical discovery assays.
  • L-ascorbic acid 2-phosphate can be used for cell differentiation as well as tissue engineering applications. Asc-2P is made use of in researches of genetics suppression, such as restraint of dihydroChemicalbook testosterone-induced dickkopf-1 expression.
  • L-ascorbic acid-2-phosphate trisodium salt can additionally be made use of as an alkaline phosphatase catalytic substrate. Alkaline phosphatase (ALP) is a vital biomarker whose abnormal expression is associated with various illness such as breast cancer, prostate cancer cells, bone illness, diabetic issues, and also liver disorder. It can also be made use of for the preparation of a photoelectrochemical parathion sensor.
  • 2-Phospho-L-ascorbic Acid Trisodium Salt is a long-acting vitamin C derivative made use of in gene reductions research. Optimize the helpful properties of vitamin C in individual care and the main energetic ingredient in lightening cosmeceuticals. In addition, it is a substratum for colorimetric amperometric discovery of tungsten in water.

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Application of Sodium L-ascorbyl-2-phosphate

L-ascorbic acid-2-phosphate trisodium salt can be used as alkaline phosphatase catalytic substrate. Alkaline phosphatase (ALP) is a vital biomarker whose unusual expression is related to numerous illness such as bust cancer, prostate cancer cells, bone disease, diabetic issues, as well as liver dysfunction. Measurable detection of ALP in product can aid in the diagnosis of related diseases. Spectroscopic evaluation has actually been extensively utilized in ALP discovery because of its simplicity as well as quick response. However, conventional spectroscopic methods based on a single material and with a single colorimetric or fluorescent output signal have poor anti-interference ability and low accuracy, and are difficult to detect targets in complex samples. With the advancement of nanotechnology, a variety of ALP colorimetric sensing methods based on nano-gold and nano-silver have been developed, but the sensitivity of such methods needs to be improved; the weak shell changes of core-shell nanoparticles can cause significant Spectral and color variations, which appear to offer the possibility to further increase the sensitivity of colorimetric detection. Some studies have provided a dual-channel detection method for alkaline phosphatase activity. The principle is that alkaline phosphatase catalyzes the hydrolysis of its substrate L-ascorbic acid-2-phosphate trisodium salt (AAP) to generate reducing ascorbic acid, which reduces ascorbic acid. Tollen’s reagent generates silver element and deposits on the surface of gold nanoparticles to form Au@AgNPs, which leads to the change of solution color and absorption spectrum; in addition, the generated Au@AgNPs can effectively quench the fluorescence of graphene quantum dots (GQDs), resulting in the change of solution color and absorption spectrum. Changes in fluorescence intensity. Thus, colorimetric and fluorescence dual-channel determination of alkaline phosphatase activity can be achieved through simultaneous changes in solution color, absorbance, and fluorescence intensity.

L-ascorbic acid-2-phosphate trisodium salt can also be used for the preparation of a photoelectrochemical parathion sensor. It belongs to the technical field of novel nanometer functional materials and biosensors. First, a new two-dimensional nanophotosensitive material Mn-MoO3/TiO2@g-C3N4 was prepared. Taking advantage of the good biocompatibility and large specific surface area of the material, parathion antibody was loaded, and then the glutaraldehyde Alkaline phosphatase is immobilized by cross-linking. During detection, since alkaline phosphatase can catalyze L-ascorbic acid-2-phosphate trisodium salt AAP to generate L-ascorbic acid AA in situ, and then provide electron donors for photoelectric detection, The effect of the specific quantitative binding of antibody and antigen on the electron transport ability is used to reduce the photocurrent intensity accordingly. Finally, a label-free detection of parathion with low cost, high sensitivity, good specificity, rapid detection and simple preparation is obtained. photoelectrochemical biosensors.

Reference

  1. Sodium L-ascorbic acid 2-phosphate – PubChem
  2. CN201811229090.6 Dual-channel detection method of alkaline phosphatase activity

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