S-Adenosyl-L-methionine CAS 29908-03-0 SAM-E
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- Appearance: White powder
- Assay: 99. 0%min
- Packaging: 25kg/drum
- Sample: Available
S-Adenosyl-L-methionine: The Complete Guide
Index ofS-Adenosyl-L-methionine Contents
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Basic Info of S-Adenosyl-L-methionine
SAM (p-toluenesulfonate); S-adenosylmethionine p-toluenesulfonic acid; S-adenosylmethionine; S-adenosyl-L-methionine (high purity); S-adenosylmethionine; S-adenosine Methionine; S-adenosylmethionine or S-adenosylmethionine; adenosylmethionine succinate
What is S-Adenosyl-L-methionine?
SAMe (S-adenosyl-L-methionine, SAM-e) is a metabolite of the combination of sulfur-containing amino acid-methionine and human body’s main energy substance adenosine triphosphate (ATP-adenosinetriphosphate). It is a physiologically active substance that exists in the human body. SAMe is neither a herbal medicine nor a hormone. It is a microparticle molecule that participates in more than 200 biochemical reactions in the human body. S-adenosylmethionine has been pointed out to promote dopamine and serotonin neurotransmitter updates and sensory functions in the brain, and may also have a repairing effect on myelin that surrounds nerve cells.
S-adenosylmethionine is very important for the health and development of many tissues and organs in the human body. It involves more than 10 individual biochemical reactions and precision and processes, such as brain function and joint health. With the help of folic acid and vitamin B. S-adenosylmethionine can provide a positive contribution to every function of the body. Normally, the body makes all the S-adenosylmethionine it needs. However, the lack of ammonium methsulfate, vitamin B or folic acid can reduce the synthesis of S-adenosylmethionine, which can reduce S-adenosylmethionine in the tissues of the elderly and patients suffering from joint, depression and different liver diseases. The quantity is extremely low.
- Application of S-Adenosyl-L-methionine in the treatment of liver disease
The liver is the main site of SAM synthesis and methylation. If the liver is damaged, the SAM synthesis of patients with liver disease will be blocked, and the synthesis of protein and nucleic acid, and the supply of polyamines and cysteine will be restricted. Cysteine is a synthetic precursor of glutathione, an important hepatoprotective agent. Clinical studies have shown that injection and oral administration of S-Adenosyl-L-methionine can effectively increase the content of glutathione in blood and liver tissue, thereby enhancing the detoxification effect of the liver, reducing or even eliminating liver damage. SAM can cause cholestasis and liver damage caused by alcohol, including liver cirrhosis and cirrhosis. Other liver dysfunctions have curative effects, especially for liver cirrhosis, which can significantly reduce the mortality rate.
- Application of S-Adenosyl-L-methionine in the treatment of depression
As early as 1973, studies have shown that SAM has the effect of treating depression. In the 1980s, SAM was used to treat depression in Europe. SAM is the main methyl donor in the brain and is involved in the synthesis of a variety of neurotransmitters. Due to its transmethylation function, it can promote the metabolism of dopamine in the brain and complex amines in the blood. The methylation of phospholipids helps to enhance receptor function, increase receptor density and improve receptor coupling.Clinical studies have proved that daily injection or oral administration of 200~1600mg SAM can effectively relieve depression, and its effect is better than placebo and equivalent to standard tricyclic antidepressants. S-Adenosyl-L-methionine has a special effect on various depressions, especially postpartum depression, and compared with other similar drugs, it has the advantages of quick action, no addiction, few adverse reactions and good tolerance. The symptoms will usually be obvious within a week. It can be used to treat patients with poor tolerance to other antidepressants, elderly patients, and depression patients with severe liver disease.
- Application of S-Adenosyl-L-methionine in the treatment of osteoarthritis
S-Adenosyl-L-methionine has anti-inflammatory, pain relief and tissue repair functions. Studies have shown that SAM has the same efficacy as the current first-choice drugs for the treatment of arthritis, ibuprofen and naproxen, and has the effect of significantly promoting cartilage formation and reducing joint pain, stiffness and swelling, with few side effects and quick results. As early as the 1970s, Europe had already used SAM as a prescription drug for treating arthritis.
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