Resveratrol(Resveracel) CAS 501-36-0

Diabetes is the most common chronic disease, but it is also one of the easiest to prevent. Because of this, people often take it lightly. The biggest problem with diabetes is arteriosclerosis. In addition to greatly increasing the chances of myocardial infarction and stroke, if it affects Kidney microvascular, and further lead to kidney failure, so how to control blood sugar is life-threatening (in the United States alone, 70,000 people die each year from diabetes complications).

In a small study, resveratrol (150 mg per day for 30 days, a DSM patented ingredient resVida) was found to improve blood sugar levels (4.2%) and insulin levels (decreased by 4.2%) in overweight individuals. 13.7%).

A recent meta-analysis also found (including 11 studies with a total of 388 people) that resveratrol can improve fasting blood sugar, insulin, and glycosylated hemoglobin in diabetic patients. The study also noted that these improvements in blood sugar markers were not found in non-diabetic patients.

According to the World Health Organization, 2.3 billion people are overweight (over 15 years old) and 700 million are obese.

Risks associated with obesity include: Type 2 diabetes, cardiovascular disease, high blood pressure, high blood lipids, and increased rates of various cancers.

Larger observations (with a 10-year follow-up period of 500,000 men and women) found that being overweight was associated with a 20% to 40% increased mortality rate, two to three times that of normal-weight individuals.

A systematic literature analysis (Systematic Review, including 7 studies with a total of 208 participants) pointed out that for overweight subjects, oral resveratrol had no significant effect on weight management, adipose tissue reduction, and abdominal obesity ( However, the only positive result was that resveratrol reduced an inflammatory marker (IL-6).

The researchers believe that weight loss is a gradual process, taking into account the limitations of small sample size, heterogeneity, and short experimental period (mostly less than 90 days), which still needs to be further confirmed in the future.

Cardiovascular disease, commonly known as heart disease, is mainly caused by insufficient blood flow to the heart tissue due to lack of oxygen. The reason why cardiovascular disease is terrible is that most of the time there are no symptoms, and once it occurs, it has a fatality rate of up to 30%, which is surprising.

Among them, coronary heart disease (ie angina pectoris and myocardial infarction) is the most common one. It is common in men between the ages of 40 and 60, and most women occur after the age of 50. It is the main cause of sudden death (about 70% of all deaths from heart disease) . In a 6-month study of 34 patients with metabolic syndrome, it was found that taking resveratrol (100 mg daily) improved blood vessel health markers: endothelial cells compared to a placebo group Diastolic function, but other blood values ​​were unchanged.

In addition, in a double-blind controlled study (sample number of 75 people, experimental period of one year), taking resveratrol can not only significantly improve a variety of inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor ( TNF-α), can also reduce the factors that cause blood clots: plasminogen activator inhibitor type I (PAI-1), which may be used as a gold component in the prevention of cardiovascular disease.

Generally, the brain will have more than one aging path. After entering old age, if the physical and mental conditions are normal, under normal aging, cognitive function usually begins to decline after the age of 80. Another path is related to dementia, which is characterized by the destruction of brain cells, which can easily lead to memory and cognitive impairment over time, and even become unable to take care of themselves.

The most common in senile dementia is: the main pathological feature of Alzheimer’s disease is the accumulation of beta-amyloid protein outside the nerve cells, resulting in abnormal cell function and necrosis, and the tangle of nerve fibers formed by the excessive accumulation of tau protein. .

In animal experiments, it has been found that administering resveratrol to experimental mice can not only prolong the average lifespan, but also reduce the aggregation of beta-amyloid and tau protein, which can protect nerve cells and slow down cognitive degradation. Research is yet to be confirmed. In a small study (in overweight middle-aged adults between the ages of 50 and 75), taking resveratrol (200 mg daily for 26 weeks) not only improved blood sugar metabolism and body fat, but also Helps improve memory performance (recall more words heard 30 minutes ago) and hippocampal connectivity/an important area for forming long-term memory.

Choroidal neovascularization is the most complex complication of macular degeneration (wet disease), these new abnormal blood vessels often lead to macular edema, retinal pigment epithelium degeneration and even retinal detachment, and if left untreated, it can lead to blindness. Vascular endothelial growth factor VEGF inhibitors are currently the main therapy for the treatment of wet macular degeneration, which can slow down abnormal angiogenesis and vision deterioration.

In a preliminary study, resveratrol was found to inhibit the vascular endothelial growth factor VEGF, which has the effect of slowing choroidal neovascularization (triggered by the inflammatory hormone TGF-β or tissue hypoxia), which may improve the disease process of macular degeneration. .

In addition, other small studies have also found that resveratrol (after 1 hour of taking it) helps increase choroidal thickness (increases blood flow, which reduces the chance of macular degeneration) compared to placebo. But so far, no studies have directly confirmed the relationship between resveratrol and age-related macular degeneration, so further confirmation is needed.

So far, the scientific community believes that the most effective way to prolong human lifespan is through calorie restriction, that is, limiting 20-40% of daily calorie intake, but under the condition of balanced nutrition, in many studies, calorie restriction Diverse species have also been shown to increase lifespan substantially (up to 60%), and while long-term studies in humans have not yet been published, preliminary evidence suggests that the results should be consistent.

In a 6-month human study, following a calorie-restricted diet was found to reduce a variety of lifespan-related values, including insulin levels, body temperature, DNA damage, and help reduce metabolic syndrome, cardiovascular disease, and cancer. Rate. In some studies, resveratrol has been found to produce disease resistance and life extension similar to the effect of calorie restriction (can activate the sirtuin 1 longevity gene).

Therefore, in a controlled animal study (both groups were fed a high-calorie diet), the experimental mice ingested resveratrol significantly improved the survival rate and reduced the mortality rate by 31% (in addition to increasing insulin sensitivity, lowering blood sugar) , improving mitochondrial production capacity, improving activity, etc.) However, the life-extending effect of resveratrol in humans has not been conclusive, so it still needs to be confirmed by more large-scale and well-designed studies in the future.

Ulcerative colitis is a type of inflammatory bowel disease. The main clinical symptoms are bloody diarrhea, abdominal cramps and other symptoms. It is a chronic inflammation caused by immune dysfunction (intestinal mucosa is the main affected part), and Patients also have a higher incidence of bowel cancer. At present, it is believed that oxidative stress and free radicals play an important role in the cause and aggravation of diseases, and resveratrol has become the target of many studies due to its excellent reactive oxygen species scavenging ability.

A double-blind controlled study (6 weeks in 56 patients with mild to moderate ulcerative colitis) found that taking resveratrol (500 mg daily) in addition to The higher the concentration of the product after the body is attacked by free radicals, the higher the oxidative stress, the higher the concentration of the body’s total antioxidant capacity and the concentration of superoxide dismutase (SOD, a type of antioxidant). In addition, disease activity and quality of life were significantly improved in the resveratrol-treated group (compared to the placebo-controlled group).