SHANDONG ZHISHANG CHEMICAL CO.LTD.

Proglumide CAS 6620-60-6

Factory Supply Proglumide CAS 6620-60-6 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Proglumide Supplier & Manufacturer

Basic Info

What is Proglumide?

Proglumide is the earliest discovered gastrin antagonist, and both it and benzotript are derivatives of glutaramic acid. Proglumide is also a racemic compound, its name is (±)-5-dipropylamino-4-benzamido-5-oxo-pentanoic acid, its English name is proglumide, and it is included in the Chinese Pharmacopoeia 2000 The second volume of the annual edition, page 96, is a gastrin receptor antagonist, and its chemical structure is similar to the terminal chemical structure of two intestinal kinins, gastrin (G-17) and cholecystokinin (CCK). Its functional group amide group specifically competes with gastrin for gastrin receptors on parietal cells, thus it can significantly inhibit the secretion of gastric acid and pepsin caused by gastrin, but has no effect on gastric acid secretion caused by histamine and vagus nerve stimulation. obvious.

Proglumide Uses

  1. Proglumide has also been proven to serve as a δ- Opioid agonists may contribute to their analgesic effects.
  2. Proglumide is a non peptide oral active cholecystokinin (CCK) – A/B receptor antagonist.
  3. Proglumide (Mild) is a drug that inhibits gastrointestinal peristalsis and reduces gastric secretion. As a cholecystokinin antagonist, it can block CCKA and CCKB subtypes. It is mainly used to treat gastric ulcers, although it has now been largely replaced by new drugs for this application.
  4. Proglumide selectively blocks the effects of CCK on the central nervous system (CNS). Proglutamide has the effect of inhibiting gastric juice secretion and protecting the gastric and duodenal mucosa. Proglumide also has anti epileptic and antioxidant activities.

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This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

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Application of Proglumide

Proglumide can increase the content of hexosamine in the gastric mucosa, promote glycoprotein synthesis, protect the gastric mucosa and promote healing, and can improve the symptoms of peptic ulcer and promote ulcer healing. The treatment of peptic ulcer and gastritis does not cause the rebound phenomenon of gastric acid secretion. After the treatment is terminated, gastric acid secretion can still be maintained at a normal level for half a year. In addition, proglumide also has choleretic effects through three pathways:

  1. By stimulating bile acid-independent bile secretion, it is beneficial to stone removal, flushing, and clearing of the bile duct.
  2. Change the stone-forming factors in bile, significantly increasing the concentration and discharge of bicarbonate, while reducing the concentrations of free bilirubin, cholesterol and calcium ions.
  3. By antagonizing CCK and inhibiting the gallbladder contraction-promoting effect of endogenous CCK, it expands the gallbladder capacity and dilutes the bile components in the gallbladder, thus preventing stone formation.

Proglumide is commonly used for gastric and duodenal ulcers, chronic superficial gastritis, and duodenal inflammation.

Pharmacological Effects of Proglutamide

References

  1. Benedetti F, Amanzio M, Maggi G (November 1995). “Potentiation of placebo analgesia by proglumide”Lancet.
  2. Li Qingeng, Fu Yubin. Improvement of the synthesis process of proglumide[J]. Chinese Journal of Medicinal Chemistry, 1995, 5(1): 54-55.

Proglumide Supplier and Manufacturer

As a proglumide supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best proglumide raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for proglumide and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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