Zileuton CAS 111406-87-2

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Zileuton

What is Zileuton?

Asthma is a common chronic disease with a prevalence of about 10% in developed countries, and its morbidity and disability rate are increasing globally. As an important mediator of airway allergic inflammation, the successful study of leukotriene antagonists is a major breakthrough in asthma treatment in recent years.

Zileuton is a novel selective 5-lipoxygenase inhibitor that antagonizes leukotriene synthesis by inhibiting lipoxygenase. Leukotrienes are highly active inflammatory substances synthesized from tetraenoic acid via the lipoxygenase pathway, and play an important role in the pathogenesis of asthma. Zileuton mechanism of action is to effectively control the development of asthmatic inflammation by inhibiting the synthesis of leukotrienes. As a new class of anti-asthmatic drugs, zileuton has certain tracheal protection, tracheal expansion and anti-inflammatory effects. In the United States, the drug has been officially included in the National Asthma Education and Prevention Program in the United States due to its positive efficacy and small side effects, as a long-term treatment for asthma control (the currently included varieties are zafirlukast and zileuton).

The chemical name of zileuton is N-hydroxy-N-[1-(2-benzothiophene)ethyl]urea, which was developed by Abbott Company in the United States and was approved by the FDA in 1997 to be marketed in the United States for prevention and treatment Chronic asthma over 12 years of age.

Zileuton Uses

  1. Zileuton is suitable for asthma, especially the trachea and bronchospasm caused by antigens, aspirin, etc., thereby improving lung function.
  2. Zileuton has obvious anti-allergic and anti-inflammatory effects in vivo and in vitro. Prevents leukotriene synthesis by inhibiting the activity of the initiating enzyme 5-LOX in the leukotriene biosynthesis pathway. It can also antagonize the effect of the leukotriene product LTB4, and inhibit the bronchial constriction and inflammatory effects of leukotrienes.
  3. Zileuton selectively inhibits 5-lipoxygenase biosynthesis for asthma.

Preparation of Zileuton

Using 2-acetoxybenzothiophene as the starting material, the target compound zileuton (4) was synthesized through three steps of oximation, reduction and condensation. The synthesis reaction conditions were mild, the operation was simple, and the efficiency was improved. Its purity can reach more than 99% through HPLC determination, and the reaction equation is as follows::

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Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
Lio Lechat
Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
Thomas Rsel
Thomas RselAustralia
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Daniel Simonson
Daniel SimonsonUnited States
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
rintero ariura
rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
Rene van Buuren
Rene van BuurenJnited Kingdom
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
Barbara Mohar
Barbara MoharSlovenia
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
Sergio Masala
Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
Bassam Zaidan
Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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