Zileuton CAS 111406-87-2
Factory Supply Zileuton CAS 111406-87-2 with Best Price
- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
Zileuton: The Complete Guide
Index of Zileuton Contents
Request A Free Quote
Basic Info of Zileuton
N-(1-Benzo[B]thiophen-2-ylethyl)-N-hydroxyurea; zilothiurine; zileuton; zileuton (standard); benzothiophen-2-yl-ethyl)urea; zileuton-D4; mitomycin impurity; zileuton impurity
Pharmaceutical raw materials(APIs)
What is Zileuton?
Asthma is a common chronic disease with a prevalence of about 10% in developed countries, and its morbidity and disability rate are increasing globally. As an important mediator of airway allergic inflammation, the successful study of leukotriene antagonists is a major breakthrough in asthma treatment in recent years.
Zileuton is a novel selective 5-lipoxygenase inhibitor that antagonizes leukotriene synthesis by inhibiting lipoxygenase. Leukotrienes are highly active inflammatory substances synthesized from tetraenoic acid via the lipoxygenase pathway, and play an important role in the pathogenesis of asthma. Zileuton mechanism of action is to effectively control the development of asthmatic inflammation by inhibiting the synthesis of leukotrienes. As a new class of anti-asthmatic drugs, zileuton has certain tracheal protection, tracheal expansion and anti-inflammatory effects. In the United States, the drug has been officially included in the National Asthma Education and Prevention Program in the United States due to its positive efficacy and small side effects, as a long-term treatment for asthma control (the currently included varieties are zafirlukast and zileuton).
The chemical name of zileuton is N-hydroxy-N-[1-(2-benzothiophene)ethyl]urea, which was developed by Abbott Company in the United States and was approved by the FDA in 1997 to be marketed in the United States for prevention and treatment Chronic asthma over 12 years of age.
- Zileuton is suitable for asthma, especially the trachea and bronchospasm caused by antigens, aspirin, etc., thereby improving lung function.
- Zileuton has obvious anti-allergic and anti-inflammatory effects in vivo and in vitro. Prevents leukotriene synthesis by inhibiting the activity of the initiating enzyme 5-LOX in the leukotriene biosynthesis pathway. It can also antagonize the effect of the leukotriene product LTB4, and inhibit the bronchial constriction and inflammatory effects of leukotrienes.
- Zileuton selectively inhibits 5-lipoxygenase biosynthesis for asthma.
Preparation of Zileuton
Using 2-acetoxybenzothiophene as the starting material, the target compound zileuton (4) was synthesized through three steps of oximation, reduction and condensation. The synthesis reaction conditions were mild, the operation was simple, and the efficiency was improved. Its purity can reach more than 99% through HPLC determination, and the reaction equation is as follows:：
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Phone: +86 176-5311 3209
WhatsApp: +86 176-5311 3209