SHANDONG ZHISHANG CHEMICAL CO.LTD.

Ramosetron hydrochloride CAS 132907-72-3

Molecular Formula: C17H18ClN3O

Formula Weight: 315.8

Purity: 99%

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Product Name: Ramosetron hydrochloride

CAS No: 132907-72-3  

Basic Info

Product Name:Ramosetron hydrochloride
Other Names:Ramosetron hydrochloride
CAS:132907-72-3
Place of Origin:Shandong, China
Brand Name:Zhishang Chemical
Type:Pharmaceuticals
Appearance:White powder
EINECS No.:/
Storage:Cool Dry Place
Purity:99%
Provide:Ramosetron hydrochloride MSDS;
Ramosetron hydrochloride COA
Synonyms:

Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride(1:1);(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazolehydrochloride;(1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanonehydrochloride;RAMOSETRONHCL;RAMOSETRONHYDROCHLORIDE;(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon;(r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr;(r)-monohydrochlorid

Product Categories:

Raw materials; organic raw materials; pharmaceutical raw materials; standard products; traditional Chinese medicine reference materials; pharmaceutical raw materials and intermediates; chemicals; raw materials; Antiemetic; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; API; chemical reagents

Description:

Ramosetron hydrochloride was launched in Japan for chemotherapy-induced emesis. Ramosetron hydrochloride was prepared by a four step sequence via the Vilsmeier-type coupling of 1- methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl -benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.

Chemical Properties:
Melting point 244-246°C
alpha D -42.9° (c 1.02 in methanol)
storage temp. -20°C
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
optical activity[α]/D -40 to -45°, c = 1 in methanol



Application:
  1. Selective serotonin 5HT3, receptor antagonist; structurally different from Ondansetron (O655000), Granisetron (G780000). Antiemetic.
  2. Prevention and treatment of gastrointestinal symptoms such as nausea and vomiting caused by anti-malignant drug treatment
About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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