N-Hydroxysuccinimide CAS 6066-82-6

Molecular Formula: C4H5NO3

Formula Weight: 115.09

Purity: 99%

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Product Name: N-Hydroxysuccinimide
CAS No: 6066-82-6

Basic Info

Product Name:N-Hydroxysuccinimide
Other Names:HOSu~1-Hydroxy-2,5-pyrrolidinedione
Place of Origin:Shandong, China
Brand Name:Zhishang Chemical
Type:Intermediate organic intermediate
Appearance:White to pale yellow
EINECS No.:228-001-3
Storage:Cool Dry Place
Provide:N-Hydroxysuccinimide MSDS;
N-Hydroxysuccinimide COA


Product Categories:

Peptide coupling; Biochemical reagents; Pharmaceutical intermediates; intermediate; Nitrogen compounds; amino acid; Chemical biology; Condensation reagent; Amide; Protective amino acids; Amino acids; Organic raw materials; Chemical Reagents; Reference substance; Traditional Chinese medicine reference substance; Other biochemical reagents; Biochemical reagents – amino acids; Organic chemical raw materials; Chemical raw materials; Basic raw materials; Chemical intermediates; Pharmaceutical, pesticide and dye intermediates; Standard; Regulator; aromatic hydrocarbon; Fine chemicals; Traditional Chinese medicine reference substance; Peptidecouplingagents; MedicalIntermediates; Heterocycles; OtherReagents; MiscellaneousReagents; Biochemistry; Condensation&ActiveEsterification; CouplinChemicalbookgReactions(PeptideSynthesis); N-SubstitutedMaleimides,Succinimides&Phthalimides; N-SubstitutedSuccinimides; PeptideSynthesis; SyntheticOrganicChemistry; CouplingReagentsSyntheticReagents; Coupling; Others; SupportedReagents; SupportedSynthesis; APIS; Zero-LengthCrosslinker; heteroXlink; Pharmaceutical raw materials; Organic chemical industry; Intermediate organic intermediate


N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It’s also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.
N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. “Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products – biliverdin, bilirubin and iron – in the dermis and epidermis … N-hydroxysuccinimide renders the iron soluble for natural elimination” (source).

Chemical Properties:

White to pale yellow

Melting point 95-98 °C(lit.)
Boiling point 215.33°C (rough estimate)
density 1.4769 (rough estimate)
refractive index 1.4080 (estimate)
storage temp. Store at +2°C to +8°C.
form Liquid or Solid
color Clear yellow-brown to brown
PH5-7 (50g/l, H2O, 20℃)
Water Solubility SOLUBLE
Sensitive Hygroscopic
BRN 113913
Stability:Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.


  1. Reagent for preparation of active esters of amino acids.
  2. N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.
  3. N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.
About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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