SHANDONG ZHISHANG CHEMICAL CO.LTD.

Modamide CAS 17440-83-4

CBNumber:CB9501409

Molecular Formula:C6H8ClN7O.HCl.2H2O

Formula Weight:302.12

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Product Name: Modamide    CAS Number: 17440-83-4              Purity: 99%

Basic Info

Product Name:Modamide
Other Names:AmilorideHydrochloride(HCl2H20)
CAS:17440-83-4
Place of Origin:Shandong, China
Brand Name:Zhishang Chemical
Type:Reference substance
Appearance:Yellow liquid
EINECS No.:620-474-8
Storage:Cool Dry Place
Purity:99%
Provide:Modamide MSDS;
Modamide COA
Synonyms:

AmilorideHydrochloride(HCl2H20);MK-870hydrochloridedihydrate;Modamide;AMILORIDEHCLDIHYDRATE;AMILORIDEHYDROCHLORIDE2-HYDRATE;PyrazinecarChemicalbookboxamide,3,5-diamino-N-(aminoiminomethyl)-6-chloro-,monohydrochloride,dihydrate;AMILORIDEHYDROCHLORIDE(500MG);AMILORIDEHYDROCHLORIDE,USP

Product Categories:

Reference substance; ion channel; membrane transport; pharmaceutical raw materials; small molecule inhibitors; potassium-sparing diuretics; pharmaceuticals potassium-sparing diuretics; bulk drugs;

Chemical Properties:
  1. Modamide is a potent potassium-sparing diuretic. It does not depend on aldosterone to retain potassium and excrete sodium. It acts on the distal end of the renal tubules, blocks the sodium-potassium exchange mechanism, promotes the excretion of sodium and chlorine, and reduces the secretion of potassium and hydrogen ions. . It mainly inhibits the exchange of Na+?K+ and Na+?H+ between the distal tubules and collecting ducts of the kidney, so that the excretion of Na+ and water increases, while the excretion of K+ and H+ decreases.
  2. Modamide this medicine can also reduce the excretion of Ca2+ and Mg2+. The combination of this medicine and potassium excretion diuretics can significantly reduce the excretion of potassium, and partly reduce the excretion of Ca2+ and Mg2+, while the effect of excretion of Na+ and water is enhanced. It has weaker natriuretic and antihypertensive activity, but it has a synergistic effect when combined with thiazides or myelin diuretics.
Application:
  1. Modamide is similar to triamterene. It directly acts on the epithelial cells of the distal convoluted tubules and collecting duct cortex, inhibits the reabsorption of K+ and Cl-, reduces the exchange of Na+-H+ and Na+-K+, and increases Na+, The excretion of Cl- and the excretion of uric acid are the strongest drugs in the current Chemicalbook for sodium excretion, potassium preservation and diuretic. This product is generally not used alone.
  2. Modamide is often used in combination with potassium excretion diuretics such as hydrochlorothiazide and diuretic acid, which can enhance the effect of diuretics and reduce the loss of potassium. This product has no hypotensive effect. It is mainly used for edema caused by liver cirrhosis and congestive heart failure that are ineffective to other diuretics.
About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Modamide Quotation