Linalool CAS 78-70-6
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- Appearance: Yellow liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Linalool suppiler
Linalool: The Complete Guide
Index of Linalool Contents
Linalool for Sale
Basic Info of Linalool
linalool terpene; linalool oil; linalyl alcohol
Plant extracts; Cosmetic additives; Pharmaceutical raw materials; Flavors and fragrances
What is Linalool?
Linalool (CAS 78-70-6) is one of the most widely distributed fragrance chemicals in nature. The aroma of the ingredients contains a strong floral aroma, similar to lavender, with some citrus aromas. In lower, more natural concentrations, it becomes extremely attractive and plays an integral role, especially in teas, apricots, peaches and blueberries.
In addition, it is suitable for other categories of fragrances, performing pure service with moderate addition levels. It is this chameleon property that has ensured the development of the fragrance industry to this day. Linalool is an incense raw material that is consistently ranked in the top 30 most widely used incense raw materials.
Linalool, also known as “linalool”, is a volatile component of tea, colorless and transparent liquid. It is converted into geraniol, nerol, α-terpineol and hydrated terpine by boiling with dilute sulfuric acid or acetic anhydride. It has the aroma of lily of the valley. It is one of the aroma substances with high content in tea, and exists in the form of glucoside in the tea tree. Linalool in free state is hydrolyzed by glucoside hydrolase after tea is picked. The content of each part of new shoots decreased sequentially from bud, first leaf, second leaf, third leaf and stem. The content of linalool is closely related to the varieties of tea plants. The Assam variant of the large-leaf species has the highest content, and the Chinese variants of the medium and small-leaf species have a lower content.
- Linalool is used in daily cosmetics such as detergents, soaps, perfumes, skin care products, and shampoos.
- Linalool can be used as food spice.
- Linalool is a harmless additive due to its excellent antioxidant and bacteriostatic properties on food.
- Linalool can be used as a pharmaceutical raw material for pharmaceutical preparations.
- Linalool has strong immunity to the human body, and has antibacterial, antiviral and antifungal effects.
- Linalool can be used to sterilize and purify the air.
- Pet care.
- Linalool repels insects and prevents pests.
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Study on the pharmacological effects of linalool
The natural active ingredients that exert analgesic effect mainly include: polysaccharides, alkaloids, flavonoids, volatile oils, saponins, etc. Among them, linalool is the most studied monoterpenoid in volatile oils.
After inhaling linalool, mice showed anxiolytic activity in light-dark tests, improved social behavior, decreased aggressive behavior, and only at high doses did side effects that impair memory function.
Aromatherapy has been used in world health care for a long time. It mainly uses the aromatic molecules in natural aromatic plants to act on human skin, respiratory tract, lungs, lymph and blood, nervous system, etc. through inhalation, massage, oral intake and other methods. Parts, resulting in health care, treatment and other effects. Lavender essential oil is a natural medicine commonly used in aromatherapy.
Linalool, the main component of lavender essential oil, has also been shown to have sedative and hypnotic pharmacological effects. After inhaling different concentrations of linalool (1%, 3%) in mice, pentobarbital-induced sleep time was prolonged, body temperature was lowered, motor behavior was slowed down, and the motor coordination of mice was not affected.
Inflammation is a defense response of the body to stimuli, mainly manifested as redness, swelling, heat, pain and dysfunction. Inflammation as the body’s defense mechanism is usually beneficial to the human body, but when it develops into chronic inflammation, it may lead to the production of other diseases, such as cancer, asthma, rheumatism, allergic dermatitis, and gastrointestinal disorders.
Although there is no anti-tumor preparation of linalool in the clinic, its anti-tumor effect and preliminary mechanism have been confirmed by many research reports. When screening anti-tumor small molecule compounds, it was found that linalool could significantly inhibit the proliferation of various human lymphocytic leukemia cells, but had no significant effect on the proliferation of normal bone marrow hematopoietic cells and peripheral blood cells.
Further studies have shown that its mechanism of action is that linalool increases the expression of DNA damage-related genes such as p53, p21, p27, and p57, and accordingly increases the expression of GADD45α, thereby activating the c-JUN/JNK apoptosis signaling pathway and initiating apoptosis. death procedure.
The research on the antibacterial mechanism of linalool oil phase shows that, compared with other plant essential oils, linalool oil has the most significant inhibitory effect on Escherichia coli, Streptococcus pneumoniae, hemolytic streptococcus, and Staphylococcus aureus, and linalool is the main Antibacterial active substances, the hydroxyl group in the structure is the center of antibacterial activity, and the minimum inhibitory concentration (MIC) is 200 μL·L-1.
In vitro antibacterial experiments revealed that linalool has a significant inhibitory effect on periodontal pathogenic bacteria and cariogenic bacteria, but high concentrations of linalool have greater cytotoxicity, so when used in combination with oral hygiene products, its concentration should be lower than 0.4g·L-1.
The antioxidant activity of linalool depends on a variety of factors, and different cell types, oxidative reaction initiators, or experimental conditions can produce dramatically different effects. It was found that in human hepatoma cells HepG2 and human lymphoid B cells NC-NC, linalool has a protective effect on tert-butyl hydroperoxide (t-BOOH)-induced cytotoxicity due to its free radical scavenging ability.
In contrast, 2,2′-azobisisobutylamidine dihydrochloride (ABAP) induced lipid peroxidation, using the thiobarbituric acid reactant method (Method A) and the conjugated diene method (Method A), respectively. B), the antioxidant activity of more than 100 volatile oil components was explored, and the results showed that linalool had no antioxidant effect at all in the determination of method B, but showed a pro-oxidative effect in the determination of method A.
Linalool biosynthesis and purification preparation method
- First, the geranyl pyrophosphate synthase gene (ERG20) from Saccharomyces cerevisiae was designed with three mutation sites (F96W, N127W, K197G), and the ERG20 gene with three point mutations was artificially synthesized, namely ERG20F96W-N127W-K197G, represented by ERG20* below;
- Secondly, by fusion PCR method, the gene ERG20* is fused with the linalool synthase gene (LIS) from Cinnamomumosmophloeum to obtain the fusion gene LIS-ERG20*;
- Then, the LIS gene with the mitochondrial localization signal peptide, namely MLS-LIS, was synthesized by artificial synthesis, and then the fusion gene LIS-ERG20* and the LIS gene MLS-LIS with the mitochondrial localization signal peptide were cloned into the plasmid On pESC-URA, a co-expression vector (pESC-URA-LIS-ERG20*/MLS-LIS) was obtained; finally, the co-expression vector was transformed into Saccharomyces cerevisiae (Saccharomyces cerevisiae BY4742-MC-01), which is a high-yielding linalool Saccharomyces cerevisiae recombinant strain YMC-01LIS-ERG20*/MLS-LIS;
- In the shake flask fermentation culture of Saccharomyces cerevisiae recombinant strain YMC-01LIS-ERG20*/MLS-LIS, preferably and further adding mevalonate or mevalonolactone or pyruvic acid or pyruvic acid in the fermentation process The salt is used as a carbon source to further increase the linalool content in the fermentation broth, and the fermentation broth is subjected to rectification treatment to obtain high-purity linalool with a purity of ≥90%. The content of mevalonic acid is 0-100g/L; the content of pyruvate is 0-10g/L.