Lamivudin CAS 134678-17-4 Lamivudine

Factory Supply Lamivudin CAS 134678-17-4 Lamivudine with Best Price

  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Lamivudin

What is Lamivudin?

Lamivudin (LMD) is a nucleoside analog that acts on the reverse transcription process of the virus and inhibits the synthesis of HBV DNA negative chain from the previous genome mRNA, thereby inhibiting the replication of hepatitis B virus. (HBV) has a strong inhibitory effect. Lamivudin and lamivudin triphosphate do not interfere with the metabolism of deoxynucleoside in normal cells, they have weak inhibitory effect on mammalian DNA polymerase, and have little effect on the DNA content of mammalian cells. Lamivudin is almost non-toxic to mitochondrial structure, DNA content and function, so therapeutic doses are not toxic to normal cells.

Because of its strong inhibitory effect on reverse transcriptase activity, it was first used in the treatment of AIDS, inhibiting HIV type 1, 2 and hepatitis B virus reverse transcriptase in vitro, and inhibiting HIV-1 in human lymphocytes and monocytes. 1,2 Viral reverse transcriptase activity, P-24 antigen and viral nucleic acid replication. It is also effective for ZDV-resistant virus strains, and can reduce the resistance to ZDV. HIV is prone to resistance to lamivudin in vitro and in vivo. First, it mutates at position 184 of the reverse transcriptase expressed by HIVpol gene, which is resistant to DDI. It has cross-resistance with DDC, and can also mutate at positions 70 and 215, and has cross-resistance with ZDV, which occurs 4 weeks after combination therapy.

Lamivudine Uses

  1. Lamivudin (commonly known as 3TC) is an antiretroviral drug used to prevent and treat AIDS, and can also be used to treat chronic hepatitis B if no other drug options are available.
  2. Lamivudin is a nucleoside analog antiviral drug that inhibits HIV and HBV. By inhibiting the reverse transcription process of the virus, it can inhibit the replication of the virus, so it has an antiviral effect.
  3. The serum HBV-DNA detection results of most hepatitis B patients showed that lamivudin could rapidly inhibit HBV replication, and its inhibitory effect continued throughout the course of treatment.
  4. Indications are: suitable for the treatment of adult chronic hepatitis B patients with liver function compensation accompanied by elevated alanine aminotransferase and viral activity replication.

Precautions while using Lamivudin

  1. It is recommended not to use this drug alone for treatment;
  2. Patients with moderate to severe renal impairment should adjust the dosage;
  3. If patients with hepatitis B virus infection are discontinued, their liver function tests and markers of HBV replication should be monitored regularly.
  4. Antiretroviral therapy (including lamivudin) cannot ensure that the risk of HIV infection caused by sexual contact and blood contamination can be prevented and should be properly prevented;
  5. In case of unexplained progressive hepatomegaly, rapid elevation of transaminase, metabolic/lactic acidosis, etc. during use, the treatment of nucleoside analogs should be stopped immediately.
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Comments from Customers

Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
Lio Lechat
Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
Thomas Rsel
Thomas RselAustralia
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Great company! thanks from Australia for good product quality, correct product, good customer service using chat.. delivery speed was ok, via FedEx. the Alibaba App finally makes it safer, so good companies like Shandong Zhi Shang can do business with us, I don't have to worry now with Alipay. Everything is safe for me now, I can't go wrong. frst time payments can just use card, the seller never knows your details, only Alibaba does the payment, so the risk is gone, delivery on time is guaranteed, and because the seller can't see your card details, scammers can't use this system, only good companies that do the right thing can make money here. it really is a much better system now.
Daniel Simonson
Daniel SimonsonUnited States
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
rintero ariura
rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
Rene van Buuren
Rene van BuurenJnited Kingdom
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
Barbara Mohar
Barbara MoharSlovenia
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
Sergio Masala
Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
Bassam Zaidan
Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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