Iminodibenzylcarbonyl Chloride CAS 33948-19-5

Factory Supply Iminodibenzylcarbonyl Chloride CAS 33948-19-5 with Best Price

  • Appearance: Green powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Iminodibenzylcarbonyl Chloride Manufacturers & Suppliers

Basic Info of Iminodibenzylcarbonyl Chloride

What is Iminodibenzylcarbonyl Chloride?

Imidodibenzyl formyl chloride is a key intermediate in the synthesis of carbamazepine. Carbamazepine is mainly used for the treatment of epilepsy, and is also commonly used in the treatment of peripheral neuralgia, manic depression and arrhythmia. drug of choice.

Oxcarbazepine is a first-line drug for the treatment of epilepsy, and its efficacy is comparable to that of carbamazepine, with fewer adverse reactions such as fatigue, ataxia, and male impotence. This product also has a strong anti-trigeminal neuralgia effect.

Iminodibenzylcarbonyl Chloride Uses

Iminodibenzyl chloride is used as a pharmaceutical intermediate.

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Application of Iminodibenzylcarbonyl Chloride

To prepare carbamazepine:

  1. Add acid chloride and chlorobenzene into another container, drop bromine into the container at 80~90℃, heat up to reflux, react under nitrogen protection for 6~7 hours, crystallize in ice methanol to obtain bromide ;
  2. Bromide, chlorobenzene and ammoniacal liquor are added to reaction unit, be warming up to 65~70 ℃, react 4~5 hours, obtain carbamazepine crude product, and the three mass ratios of bromide, chlorobenzene and ammoniacal liquor are 1:8: 1.6;
  3. Add the crude carbamazepine into ethanol and heat it at not higher than 50 °C to dissolve it completely, add activated carbon with 1~2% mass of the crude carbamazepine to decolorize, filter, cool to 10 °C, crystallize, and get the carbamazepine The finished product of Maxiping.

Preparation of Iminodibenzylcarbonyl Chloride

Add iminodibenzyl and chlorobenzene to the container, heat the temperature to 110~115°C, reflux triphosgene, and react for 5~6 hours to obtain crystalline iminodibenzylcarbonyl chloride.

Renference

  1. Iminodibenzylcarbonyl Chloride – ChemicalBook
  2. 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carbonyl chloride – PubChem
  3. [Chinese invention] CN201810660041.1 Method for synthesizing carbamazepine
  4. Liu Xutao, Li Meilian, Xiao Fangqing. Synthesis of Oxcarbazepine [J]. Chinese Journal of Pharmaceutical Industry, 2006(07):443-445.

Iminodibenzylcarbonyl Chloride Suppliers and Manufacturers

As a iminodibenzylcarbonyl chloride supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best iminodibenzylcarbonyl chloride raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have demand for iminodibenzylcarbonyl chloride and related products, please contact our service staff Zhishang Chemical – White directly, we will provide you with high-quality products at the best price.

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