|Other Names:||Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride;|
|Place of Origin:||Shandong, China|
|Brand Name:||Zhishang Chemical|
|Storage:||Cool Dry Place|
Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Phenoxybenzamine (Dibenzyline) an old but powerfulα-blocker, is a haloalkylamine that blocksα1- and α2-receptors irreversibly. Phenoxybenzamine administrationhas been described as producing a “chemical sympathectomy”because of its selective blockade of the excitatory responses of smooth muscle and of the heart muscle.Although phenoxybenzamine is capable of blockingacetylcholine, histamine, and serotonin receptors, itsprimary pharmacological effects, especially that of vasodilation,may be attributed to its α-adrenergic blockingcapability. As would be expected of a drug that producessuch a profound α-blockade, administration is frequentlyassociated with reflex tachycardia, increased cardiacoutput, and postural hypotension. There is also evidenceindicating that blockade of presynaptic 2-receptorscontribute to the increased heart rate produced byphenoxybenzamine.
|solubility||H2O: slightly soluble|
|pka||pKa 4.4 (Uncertain)|
|Water Solubility||<0.01 g/100 mL at 18.5 ºC|
- Phenoxybenzamine is used in treating pheochromocytoma, swelling of the medullary layer of the adrenal glands, during which a large quantity of epinephrine is produced, which leads to a significant elevation of blood pressure.
- alpha adrenergic blocker
- An irreversible α-antagonist. Used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers.
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
- Business Type: Manufacturer
- Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
- Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
- Total Employees: 51~100
- Capital (Million US $): 10000000RMB
- Year Established: 2016
- No. of Production Lines : 8
- No. of QC Staff : 5 -10 People
- OEM Services Provided : yes
- Factory Size (Sq.meters) : 3,000-5,000 square meters
- Certificate: ISO9001 , CE , GMP , API , MSDS
- Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
* Prompt reply and 24 hours online, professional team to provide best price and high quality product.
* Sample testing support.
* Every batch of products will be tested to ensureits quality.
*The packing also can be according the customers` requirment.
*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
*The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
*Product has any problem can return.
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Is there a discount?
Different quantity has different discount.
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.