Glycinamide hydrochloride CAS 1668-10-6

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  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Glycinamide hydrochloride

What is Glycinamide hydrochloride?

Glycinamide is an organic compound with the molecular formula H 2 NCH 2 C (o) NH 2. It is an amide derivative of amino acid glycine. It is a water-soluble white solid. Amino acid amides, such as glycine amide, are prepared by treating amino acid esters with ammonia.

Glycinamide is a ligand of transition metals.

Glycinamide hydrochloride, glycine amide hydrochloride, is one of the buffers of good, and its pH is within the physiological range. The pKa of glycinamide hydrochloride is close to the physiological pH value (8.20 at 20 ° C), so it can be used for cell culture. Its Δ PKa / ° C is -0.029 and the solubility in water at 0 ° C is 6.4 M

Glycinamide hydrochloride Uses

  1. Pharmaceutical intermediates for organic synthesis.
  2. The product is cyclized with glyoxal to obtain 2-hydroxypyrazine, and then chlorinated with phosphorus oxychloride to obtain 2,3-dichloropyrazine, which is used to produce sulfonamides smpz.
  3. Glycinamide hydrochlorideis used as a buffer in the physiological pH range.
  4. Buffer; Peptide coupling.
  5. Glycinamide a reagent used to synthesize glycine amide ribonucleotide (an intermediate in de novo purine biosynthesis).

Applications of Glycinamide hydrochloride

Join BOC- Δ Tyr (Cl 2 bzl) – Oh (307 mg, 0.7 mmol), glycine amide hydrochloride (77.4 mg, 0.7 mmol) and et 3 N (0.1 ml, 0.7 mmol) in DMF (7 ml) were added with EDC · HCl (148 mg. 0.77 mmol) and HOBt (129 mg, 0.84 mmol) at – 10 ° C. The reaction mixture was stirred at 0 ° C for 2 hours. And overnight at room temperature. After evaporation of the solution, the residue was dissolved in EtOAc. Wash the solution with 4% NaHCO3, 10% citric acid and water. The solution was dried and evaporated. BOC was purified by silica gel column chromatography- Δ Tyr (Cl 2 bzl) – Gly NH 2 (317mg, 85% yield).

( Δ Indicates the form of dehydration.)

 
References
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