Disodium pamidronate CAS 109552-15-0

Molecular Formula: C3H14NNaO8P2

Formula Weight: 277.08

Purity: 99%

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Product Name: Disodium pamidronate

CAS No: 109552-15-0     

Basic Info

CAS No.:

109552-15-0

MF:

C3H9NNa2O7P2

Place of Origin:

Shandong, China

Purity:

99.0%

Application:

INTERMEDIATE

Product Name:

Disodium pamidronate

 
 

Other Names:

pamidronate disodium

EINECS No.:

260-647-1

Type:

Pharmaceutical Intermediates

Brand Name:

Zhishang Chemical

Provide:Disodium pamidronate MSDS;
Disodium pamidronate COA
Synonyms:

disodium(3-amino-1-hydroxypropylidene)bisphosphonatepentahydrate;disodiumdihydrogen(3-amino-1-hydroxypropylidene)diphosphatepentahydrate;phosphonicacid,(3-amino-1-hydroxypropylidene)bis-,disodiumsalt,pentahydrat;AMINOMUX;AREDIA;GCP-23339A;disodium3-amino-1-hydroxy-propylidenebisphosphonate;3-AMINO-1-HYDROXYPROPYLIDENE-BISPHOSPHONICACID,2NA

Product Categories:

Pamidronate disodium phosphate API 109552-15-0; organic raw materials; APIs; pharmaceutical raw materials and intermediates; pharmaceuticals, pesticides and dye intermediates; pharmaceutical raw materials; chemical reagents; Metabolite&impurity; Antiosteoporotic

Description:

Disodium pamidronate, a second-generation bisphosphonate, is 100-fold more potent than etidronate. It has been approved for the treatment of hypercalcemia of malignancy, for Paget’s disease, and for osteolytic bone metastases of breast cancer and osteolytic lesions of multiple myeloma. When used to treat bone metastases, pamidronate decreases osteoclast recruitment, decreases osteoclast activity and increases osteoclast apoptosis. Erosive esophagitis has been reported with the use of pamidronate sodium.

Chemical Properties:

White or almost white, crystalline powder.

storage temp. 2-8°C
solubility Soluble in water, practically insoluble in methylene chloride. It is sparingly soluble in dilute mineral acids and dissolves in dilute alkaline solutions.
form White solid
CAS DataBase Reference109552-15-0(CAS DataBase Reference)



Application:
  1. Disodium pamidronate (aminopropanediphosphonate, pamidronete, APD) is a pyrophosphate analog that effectively inhibits bone resorption. It has a strong affinity for calcium phosphate. It inhibits the absorption of hydroxyapatite crystals than it inhibits the need for formation and growth. The amount is much lower, so a small dose can produce curative effects. APD introduces amino groups at the end of the carbon chain, and its biological activity is greatly enhanced. Its effect of inhibiting bone resorption is 100 times stronger than etidronate and 10 times stronger than clodronate. As a bone resorption inhibitor, APD is used to treat tumor hypercalcemia, Paget’s disease and bone metastasis of malignant tumors, with significant curative effect and small side effects.
  2. Disodium pamidronate is used for malignant tumors complicated by hypercalcemia and bone pain caused by osteolytic cancer metastasis; Osteitis deformans (Paget’s disease) and osteoporosis caused by various reasons; Chemicalbook Parathyroid gland Hyperfunction; treatment of excessive lytic bone destruction caused by tumor bone metastasis and its complications (such as bone pain, pathological fracture, etc.); it can also be used for multiple myeloma
Storage:
Storage condition: Cool Dry Place
 
Long term storage: Store below 2-8°C.
 

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service


*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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