Product Name: Collagenase CAS Number: 9001-12-1 Purity: 99%
|Other Names:||COLLAGENASE TYPE X|
|Place of Origin:||Shandong, China|
|Brand Name:||Zhishang Chemical|
|Storage:||Cool Dry Place|
COLLAGENASE TYPE X;Collagenase from Clostridium histolyticum;collagenase crude type ia cell culture*tested;collagenase F. clostridium histolyticum;collagenase from achromobacter iophagus;collagenase sterile filtered type vii-S;collagenase type I-S;Collagenase A
- It are a category of enzymes that can digest native, the major fibrous component of animal extracellular connective tissue. it can be produced by some bacterias such as Clostridium and can also be made by the animal body as part of its normal immune response.
- It they normally target the connective tissue in muscle cells and other body organs. They can break peptide bonds within it and help create it by cleaving pro-collagen, it precursor, once it is secreted by the cell. Bacterial it exhibit broader substrate specificity than animal it and unlike animal collagenases that split it in its native triple-helical conformation, bacterial collagenase can degrade both water-insoluble native it and water-soluble denatured ones.
- It in addition, bacterial collagenase can attack almost all it types, and is able to make multiple cleavages within triple helical regions.
- Collagenases have a molecular weight ranging from 68 kilodaltons (kDa) to 130 Kda due to differing sizes based on the class to which the isolate belongs. The optimal pH for stability ranges from approximately 6.3 to 7.5 with a theoretical isoelectric point of 5.62. Numerous compounds and molecules have the capability of acting as it activator or inhibitor. For example, Ca2+ and Zn2+ ions are two known activators. On the other hand, ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA), cysteine, histidine, dithiothreitol (DTT), 2-mercaptoethanol, o-phenanthroline, Hg2+, Pb2+, Cd2+, Cu2+, and Zn2+ are all known inhibitors of collagenase activity.
- Collagenase this is has been tested with cell lines to verify the product is not cytotoxic. It is typically used to digest the connective components in tissue samples to liberate individual cells. The concentration for cartilage dispersal is 1-2 mg/ml, but literature searches should be performed for species specific and/or tissue specific concentrations.
- Collagenase in investigation of the structure and biosynthesis of collagen; in dispersion of cells for tissue culture studies.
- Collagenase a rare proteinase that catalyzes the hydrolysis of it. Collagenase activity has been demonstrated in several venoms of crotalid and viperid snakes and it occurs in certain species of clostridium.
- Collagenase plays an important role in wound healing and scar formation. It can not only serve as a prerequisite for elastic tissue and adhesion substances, but also stimulate cell development, differentiation and tissue differentiation and proliferation, and connective tissue differentiation and proliferation. Stimulate the growth of new Chemicalbook of capillaries, make monocytes and fibroblasts chemoattractant, and still have nutrition and regulation of granulation tissue. According to reports, the use of it to treat skin ulcers caused by different reasons has shown a good effect. It can make the surface and deep epithelialization of the ulcer, which is conducive to the formation of granulation tissue.
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
- Business Type: Manufacturer
- Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
- Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
- Total Employees: 51~100
- Capital (Million US $): 10000000RMB
- Year Established: 2016
- No. of Production Lines : 8
- No. of QC Staff : 5 -10 People
- OEM Services Provided : yes
- Factory Size (Sq.meters) : 3,000-5,000 square meters
- Certificate: ISO9001 , CE , GMP , API , MSDS
- Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
* Prompt reply and 24 hours online, professional team to provide best price and high quality product.
* Sample testing support.
* Every batch of products will be tested to ensureits quality.
*The packing also can be according the customers` requirment.
*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
*The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
*Product has any problem can return.
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Is there a discount?
Different quantity has different discount.
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.