4-Fluorobenzoic acid CAS 456-22-4

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Basic Info

Product Name:4-Fluorobenzoic acid
Other Names:4-FLUOROBENZOIC ACID;AKOS 92636;4-fluoro-benzoicaci;Benzoic acid, p-fluoro-;Benzoicacid,4-fluoro-;fluorobenzoicacid;para-Fluorobenzoic acid;p-Fluorobenzoic Acid 4-Fluorobenzoic Acid
Place of Origin:Shandong, China
Brand Name:Zhishang Chemical
Type:carboxylic acid| alkyl Fluorine;Carboxylic Acids;Benzene derivatives;Phenyls & Phenyl-Het;C7;Carbonyl Compounds;Fluorin-contained Benzoic acid series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Phenyls & Phenyl-Het;Fluorobenzene;API intermediates
Appearance:White powder
EINECS No.:207-259-0
Storage:Cool Dry Place
Provide:4-Fluorobenzoic acid msds;4-Fluorobenzoic acid COA

Chemical Properties:

4-Fluorobenzoic acid Chemical Properties
Melting point 182-184 °C (lit.)
Boiling point 117 °C
density 1.479
storage temp. Sealed in dry,Room Temperature
solubility alcohol: soluble
pka 4.15(at 25℃)
form Crystalline Powder
color White to slightly yellow
Water Solubility Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water.
Merck 14,4171
BRN 1906922
CAS DataBase Reference 456-22-4(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 4-fluoro-(456-22-4)
EPA Substance Registry System Benzoic acid, 4-fluoro- (456-22-4)


  1. 4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the 18F labeling of antibodies. It has been used in high resolution charge density study.
  2. 4-Fluorobenzoic acid AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356
  3. 4-Fluorobenzoic acid is an organic intermediate, slightly soluble in cold water, soluble in hot water, soluble in most organic solvents. The use of fluorobenzene acid is a derivative of argon acid, which can be used as a pesticide, pharmaceutical intermediates.4-Fluorobenzoic acid has been reported that fluorobenzene acid can be used to prepare fluorobenzene formaldehyde. Chemical properties of this product for white solids, easy sublimation, m.p.184 to 187 degrees C, insoluble in water, soluble in alcohol, ether and other organic solvents. The use of fluorobenzene acid is an intermediate of the fungicide fluoroquine. Organic synthesis intermediates.
  4. There are standard reagents for Chemicalbook machine micro-analysis to determine fluorine. 4-Fluorobenzoic acid used as a pesticide, pharmaceutical intermediates for high-resolution charge density research production methods after heavy nitride reaction with fluoroboric acid, the resulting heavy nitrogen fluoroborate heating decomposition to produce ethyl fluorobenzene, and then its hydrolysis to fluorobenzene acid. The production method preparation method is to react with sodium borate (NaBO3.4H2O) in acetic acid solution, the temperature is 40 to 50 degrees C, and the reaction is about 1h product.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.