Alpha-Lipoic acid CAS 1077-28-7

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  • Appearance: Yellow powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Alpha-Lipoic acid

What is Alpha-Lipoic acid?

Alpha-lipoic acid is an organosulfur compound derived from caprylic acid, normally produced in animals and essential for aerobic metabolism.

Alpha-lipoic acid is a nutrient that helps convert glucose into energy in the body. Alpha-lipoic acid is also an antioxidant that neutralizes free radical harmful chemicals. It works in water and fat, respectively, and supports the antioxidants vitamin E (acts only in fat) and vitamin C (acts only in water), allowing them to regenerate antioxidant capacity after neutralizing free radicals.

Alpha-Lipoic acid Uses

  1. Vitamin drugs can stimulate fat metabolism. For the treatment of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes and other diseases and curative effect health care.
  2. Antioxidants and coenzymes such as pyruvate dehydrogenase and glycine decarboxylase (glycinChemicalbookedecarboxylase), exogenous lipoic acid is reduced by two or more intracellular enzymes. This reduced form affects the process by which cells scavenge free radicals. Increase glutathione (glutathione) synthesis, regulation of transcription factor activity. Decreased phagocytosis of myelin by macrophages.
  3. This product can reduce lipid oxidation in nerve tissue, prevent protein glycosylation, and inhibit aldose reductase, which can prevent the conversion of glucose or galactose into sorbitol, so DL-lipoic acid can prevent diabetes and control blood sugar. And prevent neuropathy caused by hyperglycemia.
  4. When used together with hypoglycemic drugs, the hypoglycemic effect is strengthened, and the risk of hypoglycemia may occur.
  5. May inhibit the efficacy of cisplatin.

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Preparation of Alpha-Lipoic acid

First weigh 100g of vinyl chloride and put it into a 500mL three-necked flask equipped with a stirrer, a dropping funnel and a thermometer, at normal temperature, add 25mL of 65% sulfuric acid solution to it, then place the three-necked flask in an ultrasonic shaker , the ultrasonic frequency is 25KHz, and the ultrasonic power is 100W for 35min of vibration reaction. After the vibration reaction ends, the temperature of the three-necked flask is raised to 85°C at a rate of 3°C/min, and 50mL of 80% trichloride is slowly added dropwise to it. The methane solution was added dropwise within 15 minutes, and the stirring state was maintained during the dropwise addition. After the dropwise addition was completed, the temperature was raised to 50 °C, and the pressure was raised to 0.2 MPa. After 1 h of polymerization, 1, 2, 5, 7 – tetrachlorooctane;

Then, the resulting 1,2,5,7-tetrachlorooctane was poured into a container, and 1,2,5,7-tetrachlorooctane mass 1 times sodium hydroxide was added to it, and the temperature was 500r at 40°C. Stir at a rate of /min for 5 minutes, wait for the stirring to end, let stand for 40 minutes, filter, and remove the residue to obtain 2,4,6-trieneoctanol; Next, the 2,4,6-trieneoctanol obtained above is Put it in the reactor, seal the reactor, under the condition that the temperature of the reactor is 110°C and the pressure is 0.5MPa, pass H2S to the bottom of the reactor at a rate of 2L/min, stop feeding after 25min, and cool to room temperature by itself, Generate 4,6-diene-α-lipoic acid; then feed hydrogen chloride at a rate of 3L/min at the bottom of the reactor containing 4,6-diene-α-lipoic acid, and at the same time, feed hydrogen chloride at a rate of 8 The rate of ℃/min raises the temperature of the reactor to 160 ℃, the pressure of the reactor is to 0.6MPa, stops feeding after 20min, and uses a fan to rapidly cool it to room temperature to obtain α-lipoic alcohol;

The α-lipool obtained above is then placed in a fixed reactor, 50% calcium oxide of α-lipool quality is added, and the preferred temperature range of control is 45 ° C, the pressure range is 1MPa, and the stirring reaction is 15min, and the stirring is completed, Then increase the optimal temperature range to 48 ° C, pressure range to 1.2 MPa, continue to stir and react for 10 min, then add α-lipoic alcohol mass 30% magnesium oxide, mix well, let stand for 45 min after reaction, put in ice The temperature was lowered to 3°C in the bath to obtain crystals, filtered to obtain a filtrate; finally, a 35% hydrochloric acid solution was added to the obtained filtrate, and the pH was adjusted to 1, then placed in an oven and dried at 105°C to a constant weight, then the dried product is put into a pulverizer, and pulverized through a 100-mesh sieve to obtain α-lipoic acid.

Quality Control of Alpha-Lipoic acid

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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
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The product was good and the person who dealt with it was kind!
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.

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