
Praziquantel CAS 55268-74-1



Factory Supply Praziquantel CAS 55268-74-1 with Best Price
- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Praziquantel Supplier & Manufacturer
Praziquantel: The Complete Guide
Praziquantel for Sale
Basic Info
Chemical Name: | Praziquantel |
Other Name: | Praziquantel powder; Praziquantel raw material |
CAS: | 55268-74-1 |
EINECS: | 259-559-6 |
Type: | Feed additives; Pharmaceutical raw materials; Raw materials of pesticides; Pharmaceuticals, dyes, pesticide intermediates |
Molecular Formula: | C19H24N2O2 |
Molecular Weight: | 312.41 |
Melting point | 136-138 C |
Boiling point | 1377℃ |
density | 1.1209 (rough estimate) |
refractive index | 1.5600 (estimate) |
Fp | >110°(230°F) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | ethanol: soluble5mg/mL |
pka | -0.98±0.20(Predicted) |
form | powder or crystals |
color | Crystals from EtOAc/hexane |
Water Solubility | Freely soluble in ethanol or dichloromethane. Slightly soluble in water |
Brand Name: | Zhishang Chemical |
Provide: | Praziquantel MSDS; Praziquantel COA |
What is Praziquantel?
Trematodes is an overlooked exotic condition that seriously jeopardizes human health as well as affects social and economic advancement. Today, schistosomiasis prevails in 76 nations and also regions in the world, with virtually 200 million infected individuals and also virtually 800 million citizens encountering the risk of infection j. Schistosomiasis is primarily widespread in my country. By the end of 2010, there were 453 schistosomiasis-endemic regions nationwide, with 325,800 schistosomiasis patients.
Praziquantel is a broad-spectrum anthelmintic synthetic drug uncovered abroad in the 1970s. After it was reported to be efficient against schistosomiasis in 1977, it was trial-produced in China in the exact same year and confirmed to have a considerable result on schistosomiasis. This product is an anemic crystalline powder, Odorless as well as slightly bitter, very steady under typical conditions. Soluble in chloroform, dimethyl sulfoxide and other natural solvents, slightly soluble in ethanol, barely soluble in water. The histochemical observation results of in vivo and also in vitro examinations showed that after the activity of the medication, the glycogen of schistosomiasis reduced dramatically, ribonucleic acid and alkaline phosphatase also reduced, while the activity of alkaline healthy protein reaction or acid phosphatase enhanced. It is likewise believed that after the medicine acts upon the worm body, the skin of the worm will promptly denature, as well as the surface antigen of the worm will be exposed, to make sure that it can not escape the immune attack of the host. The medication can additionally advertise fast liver movement of worms. Animal experiments have actually shown that when the blood concentration gets to 0.3 μg/ ml, it has insecticidal result and also high restorative index. The medication is conveniently soaked up by the intestine, and also the blood concentration gets to the peak in about 2 hrs. The circulation in the body has the highest possible focus in the liver, and also most of the metabolites after the medication is metabolized are excreted by the kidneys within 24 hours without buildup. This product likewise has a considerable result on the larvae of Mansoni as well as Schistosoma japonicum that initially go into the skin. At reduced concentrations, it can kill miracidia and also cercariae, as well as can prevent the advancement of schistosome larvae of spirochetes right into cercariae. Praziquantel has a good restorative effect on schistosomiasis, and additionally has satisfying medicinal results on clonorchiasis, paragonimiasis and also tapeworm.
Praziquantel Uses
For a variety of intestinal parasitic diseases. This product has the effect of repelling and killing various parasites such as Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium, Clonorchis sinensis, paragonimiasis, fasciola japonicum, tapeworm and cysticercosis.
Praziquantel is used to prevent schistosome infection. External application on the skin can be used to prevent schistosomiasis infection.
Praziquantel has broad-spectrum anti-schistosome and anti-tapeworm effects. It has extremely high activity against adults of various tapeworms, and also has good activity against larvae; it has a good killing effect on schistosomes. It has repellent effect on the Monitz tapeworm, the ball spot worm and the yolkless gland tapeworm, and it is effective against the pancreas fluke and the lanceolata; it is also effective against the thin-necked cysticercosis and Schistosoma japonicum of cattle and sheep. Good effect; it has good relative effect on cysticercosis of pigs; it has high efficiency on various tapeworms of dogs, cats and poultry.
The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
Contact Us
- Email: sales002@sdzschem.com
- Phone: +86 176 5311 3209
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If you want to buy praziquantel, pls contact us to get a free quote.
Application of Praziquantel
Studies have shown that praziquantel can interfere with the Ca2+ internal environment of schistosomes. Praziquantel may change the permeability of worms to Ca2+, promote inflow and contracture of worms, or change the distribution of Ca2+ in cortical cytoplasm and muscle and cause cortical damage; It is manifested as the activity of the worm body, followed by the contraction of the worm body. These reactions depend on the existence of Ca2+ and are restricted by M. The schistosomiasis cultured in vitro can cause cortical damage after being treated with praziquantel for 5 minutes, white blood cells and macrophages It is easy to enter the insect body through the damaged part and further decompose the insect body.
The internal environment of Ca2+ in Schistosoma cells can be regulated by some cellular components, such as: voltage-gated calcium channels (Voltagegated calcium channels, VGCCs), ligand-gated calcium channels, second messenger-gated calcium channels, etc., these channels may become praziquantel Targets for regulation of Ca2+ homeostasis.
The mode of action of praziquantel may be as follows: ① Praziquantel can combine with the protein dimer of the same amount in the dimer interface groove to form crystals, thereby inhibiting the catalytic activity of schistosomal japonicum. ② Praziquantel can block the combination of poison and Schistosoma japonicum GST, so that the poison can accumulate in the worm. However, there are also studies that praziquantel does not inhibit the activity of Schistosoma japonicum GST, and is not the target molecule of praziquantel.
Actin is a highly conserved protein family that exists in all eukaryotic cells. It is the main component of the cytoskeleton and participates in cell division, movement, migration and shape maintenance. It mainly composes muscle filaments and completes muscle contraction.
Experiments showed that the molecular size of the membrane surface bound to praziquantel was 45 kDa, and amino acid sequencing showed that most of it was composed of actin. Praziquantel may bind to the lipid bilayer membrane of schistosomiasis and cause cortical damage, leading to antigen exposure, including actin exposure. The combination of praziquantel and actin of Schistosoma japonicum may cause changes in molecular conformation, affect the function of actin, severely damage the integrity of the cortex, and change the physiological traits of Schistosoma japonicum.
Praziquantel cannot kill Schistosoma japonicum eggs, but it can significantly reduce the granuloma of eggs or directly lead to the regression of granulomas, and it has a cellular immunosuppressive effect on the inflammatory cell reaction around Schistosoma japonicum eggs, so it can be considered as praziquantel Ketone directly inhibited egg granuloma, and the mechanism of inhibiting egg granuloma is likely to be the regulation of host immune function. Praziquantel, due to its short half-life, requires the subsequent engagement of the host immune system, otherwise the damaged schistosomiasis has the potential to recover.
Adverse Reactions
Generally mild and short-lived, does not affect the treatment. Common ones are:
- Neuromuscular reactions: such as headache, dizziness, fatigue, etc.
- Digestive system reactions: abdominal pain, nausea, etc., occasionally blood in the stool, liver pain.
- Cardiovascular system reactions: Chest tightness, palpitations, premature contractions, etc. are more common, occasionally supraventricular tachycardia, atrial fibrillation, etc., ECG can show transient changes, T wave changes and premature contractions are more common.
- Allergic reactions: skin rash, fever, etc. Severe reactions such as fainting, flaccid paralysis, angina pectoris, severe arrhythmia, jaundice, etc. are only seen in individual cases, and most of them disappear quickly.
Reference
- Praziquantel – WikiPedia
- Li Xin; Xia Chaoming. Research progress on the mechanism of action of praziquantel against schistosomiasis. 2008. PhD Thesis.
Praziquantel Supplier and Manufacturer
As a praziquantel supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best praziquantel raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for praziquantel and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide the best price and high-quality product.
* Sample testing support.
* Every batch of products will be tested to ensure its quality.
* The packing also can be according to the customers` requirement.
* Any inquiries will be replied to within 24 hours.
* We provide a Commerical Invoices, Packing Lists, Bills of loading, COA, Health certificates, and Origin certificates. If your markets have any special requirements, let us know.
After-Sales Service
* The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
* Product has any problem can return.
Do you accept sample order?
We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
Is there a discount?
The different quantity has different discount.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
1. ≤50kg, Express delivery recommended, usually called DDU service;
2. ≤500kg, Air shipping recommended, usually called FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called FOB, CFR, or CIF service;
4. For high-value products, please select air shipping and express delivery for safe.
Quality Control of Praziquantel

