Potassium Tetrachloroplatinate CAS 10025-99-7

Potassium chloroplatinite is a dark red prismatic flaky crystal, easily soluble in water, 0.93g (16°C) and 5.3g (100°C) in 100mL water, insoluble in alcohol and organic solvents, stable in air, but Contact with ethanol will be reduced.

Potassium chloroplatinate is an important intermediate in the preparation of antitumor drugs such as carboplatin, cisplatin and oxaliplatin, and has a good market prospect. At present, about the preparation method of potassium chloroplatinite, only few literatures report the preparation of its laboratory. It is mentioned in the literature that potassium chloroplatinate is used as a raw material, and potassium oxalate, hydrazine hydrate and sulfur dioxide are used as reducing agents to synthesize potassium chloroplatinite.

Due to the weak reducing ability of potassium oxalate, the main metal content of the synthesized product is difficult to meet the requirements; the reducing ability of hydrazine hydrate is strong, and it needs to be diluted by a certain multiple to meet the reaction requirements, and its toxicity is also a problem that cannot be ignored; Compared with the liquid reaction system, the gas-liquid two-phase is introduced into the system, which is more difficult to operate and is not environmentally friendly.

The method disclosed in patent JP3131529 uses chloroplatinic acid as raw material and hydrazine dihydrochloride as reducing agent. The disadvantage of this method is that in the preparation of potassium chloroplatinate solution, hydrochloric acid is used as solvent, and its concentration is strictly limited. Moreover, the preparation process is lengthy and the production cost is high.