Polyhexamethylene Biguanide Hydrochloride CAS 32289-58-0 PHMB
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- Appearance: Cololrless or light yellow liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Polyhexamethylene Biguanide Hydrochloride Supplement
Polyhexamethylene Biguanide Hydrochloride: The Complete Guide
Index of Polyhexamethylene Biguanide Hydrochloride Contents
Polyhexamethylene Biguanide Hydrochloride for Sale
Basic Info of Ammonium alginate
Polyhexamethylene Biguanide Hydrochloride; Polyhexamethylene Biguanidine HCl; Biguanide PHMB; Poly(hexamethylenebiguanide)hydrochloride; Polyhexanide; PHMB
Pharmaceutical raw materials; Cosmetic raw materials
What is Polyhexamethylene Biguanide Hydrochloride?
Polyhexanide (Polyhexamethylene biguanide hydrochloride, PHMB) is a polymer used as a disinfectant and antiseptic. Spelled Polihexanide (inn) for dermatological purposes and sold under the names lavasept, serasept, prontosan and omniside. PHMB has been shown to be resistant to Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Yeast infection albicans, Aspergillus Brazil, Enterococcus as well as Klebsiella pneumoniae.
The average molecular weight of polyhexamethylene biguanide hydrochloride is 1100-1800, the molecular formula is (C8H17N5)n·xHCl, n=12-16. Polyhexamethylene biguanide hydrochloride (PHMB) is a broad-spectrum antibiotic that can kill gram-positive bacteria, gram-negative bacteria, fungi and yeast.
Polyhexamethylene biguanide hydrochloride solution is a colorless or light yellow transparent liquid, in which the guanidine group has high activity, which can make the polymer into a positive charge, and it is easily attacked by various negatively charged bacteria and bacteria. The virus is adsorbed, thereby inhibiting the division ability of bacteria and viruses, making them lose their reproductive ability, and the film formed by the polymer blocks the respiratory channels of the microorganisms, causing the microorganisms to die quickly.
Polyhexamethylene Biguanide Hydrochloride Uses
- For a long time, polyhexamethylene biguanide hydrochloride PHMB has been widely used in medicine for bactericidal and antiseptic. As a medicinal product, it is used for disinfection of contact lenses, eye drops, and surgical procedures.
- Due to the high tolerance of the eye to PHMB, polyhexamethylene biguanide hydrochloride can be used as an agent for the treatment of acanthamoeba keratitis, prevention and treatment of other eye diseases.
- Polyhexanide is also widely used in cosmetics, personal care products, textiles, food industry, etc.
- Polyhexamethylene biguanide hydrochloride is used as a flocculant, as a bactericide and algaecide in swimming pools and industrial water treatment, as a bactericide in oil production and injection water, and can clean and remove harmful substances on glassware and other hard surfaces.
- Disinfectant. This bactericide is broad-spectrum antibacterial and has the ability to kill gram-positive bacteria, gram-negative bacteria, fungi and yeast, etc. It can be used as a fungicide and is often used in swimming pool bactericides and all-purpose cleaners and disinfectant products.
- Polyhexanide is likewise made use of as a component in some get in touch with lens cleansing products, cosmetics, personal deodorant and also some veterinary items. It is also used to handle clothing (purista), allegedly to prevent unpleasant odors.
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Application of Polyhexamethylene Biguanide Hydrochloride
Its antibacterial effect is mainly by dissolving lipids, changing the permeability of bacterial cell membranes, and causing obstacles to metabolism in bacteria. It is colorless, odorless, non-irritating to the skin, non-toxic and non-corrosive. Therefore, the wet wipes treated with it can achieve rapid disinfection effect without mildew, and the shelf life can be up to two years.
It is suitable for household disinfection, and can be used for sterilization and cleaning of fruits and vegetables; it is used for sterilization and cleaning of various fabrics such as clothing, towels, bed sheets, etc.; Sterilization of the place.
This product can quickly kill harmful bacteria such as Gram-negative bacteria, Floating Vibrio, Vibrio parahaemolyticus, Vibrio alginolyticus in seawater, and is very good for various diseases caused by bacteria in sea cucumber and other aquatic products. preventive and therapeutic effects.
The product is colorless, non-corrosive, and has a long-lasting effect. It can be conveniently used for cleaning and disinfection of skin, wounds, obstetrics and gynecology, and urology. Especially for some medical supplies that cannot be disinfected by high temperature, only a solution with a concentration of 1‰ is required. Soaking or spraying can achieve satisfactory sterilization effect in a short time. The product can also be used for disinfection of air, walls and floors in wards.
The lotion and gel disinfectant made by this product can be used for bacterial, fungal, trichomoniasis, senile and non-specific inflammation, cervicitis and other diseases.
The product is sprayed directly on the hands as a hand sanitizer, which can safely, effectively and conveniently remove pathogenic bacteria on the hands, no water and soap, and can form a colorless layer on the hands. Transparent invisible film, maintain long-term inhibition and sterilization effect.
The product can develop antibacterial textiles, such as towels, underwear, baby clothes, bedding and so on. Simply immerse the textile in the product-specific solution before the final finishing stage. When bacteria fall on the textiles treated by this product, a small amount of water dissolves the active substances contained in them, and kills bacteria quickly. After tests, properly treated textiles are still antibacterial after washing up to 120 times in water.
The product can easily develop various types of sterile and antibacterial sanitary napkins, sanitary pads, baby diapers, etc., which reduces the cost and solves the problem of short validity period of traditional disinfection methods. Because the product can be evenly linked with the fine fibers of the above products, a thin polymer layer of antibacterial agent is formed on the surface, which can maintain the best state after sterilization, and the validity period can be up to two years.
At present, the washing products with disinfection function are generally added with chlorine preparations as disinfection ingredients, which have defects such as corrosiveness to fabrics, fading, short sterilization validity period, and can only be used for white fabrics. The product has the advantages of being soluble in water, non-toxic, colorless, odorless, non-corrosive, non-fading, non-irritating to skin and mucous membranes, and has a long validity period.
The product is used in the sterilization and disinfection of pipelines, containers and other production facilities and floors in the production of beer, beverage and food. It only needs to dilute the product to 10ppm and soak or flush the pipeline to achieve the sterilization effect. If there are no special requirements for filling food cans, the use concentration can be increased to 250ppm to achieve the effect of quickly and completely killing bacteria.
Preparation of Polyhexamethylene Biguanide Hydrochloride
To a three-necked flask equipped with a thermometer and a stirring rotor, ethanol was added as a solvent to weigh 1,6-hexanediamine, and hydrochloric acid was added dropwise with stirring, and the reaction was exothermic. Control the dropping rate, keep the temperature below 28°C during the dropwise addition until the pH value of the solution reaches 5, continue the reaction for 1 hour after the dropwise addition is completed to ensure that the reaction is complete, then reduce the temperature to 0°C, filter, and filter the obtained filter cake drying. Then pure hexamethylenediamine hydrochloride is obtained.
- Polyhexanide – WikiPedia
- “Classification and Labelling of PHMB”. European Chemicals Agency.
- Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride – ChemicalBook
- Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride – PubChem