Polyethylene-polypropylene Glycol CAS 9003-11-6
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Polyethylene-polypropylene Glycol: The Complete Guide
Polyethylene-polypropylene Glycol for Sale
Basic Info of Polyethylene-polypropylene Glycol
188 Polyethylene-polypropylene glycol; Pluronic 17R2/Synative RPE1720; Polyethylene polypropylene glycol
Food additives; Pharmaceutical raw materials; Organic raw materials; Pharmaceutical, pesticide and dye intermediates
What is Polyethylene-polypropylene Glycol?
Polyethylene-polypropylene glycol are oligomers including ether bonds (ROR) in the molecule as well as OH groups as end groups. It is made of low molecular compounds consisting of active hydrogen such as (alcohols, amines) as the beginning representative, as well as under the activity of a driver, it is integrated with ethylene oxide (EO), propylene oxide (PO), butylene oxide (BO) It is developed by ring-opening polymerization. The biggest polyether return is using glycerol (glycerol) as the initiator and epoxide (usually PO as well as EO are made use of in combination). Numerous general polyether polyol were produced under conditions such as the feeding series. Polyethylene-polypropylene glycol is an important chemical basic material, and also its greatest use is to synthesize polyurethane (PU) resin products, such as polyurethane foam, polyurethane adhesive, polyurethane adhesive, polyurethane elastomer, etc. On top of that, it can likewise be utilized as non-ionic surfactants, lubricants, liquid fluids, heat exchange fluids, and so on.
The polymerization response of the very early synthesis of polyether polyol was performed under the action of acid or base catalysis. The generally previously owned acid stimulants were protonic acids (H2SO4, HCl, etc) and Lewis acids (AlCl3, BF3, and so on), as well as the base catalysts were frequently used antacids. Oxides, alcoholates as well as hydroxides of metals, antacids (planet) steels.
Polyethylene-polypropylene Glycol Uses
Nonionic surfactant, soft and hard surface cleaner, defoamer in coatings and water treatment. Polyethylene-polypropylene glycol metalworking lubricants, defoaming aids and extenders for linear and cross-linked polyesters and polyurethanes.
Poloxamer is a nonproprietary name for polyether polyol copolymer. The product produced by German BASF company is called Pluronic, in which the polyoxyethylene chain is relatively hydrophilic, and the polyoxypropylene chain is relatively lipophilic, so it is a non-ionic polymer surfactant. It is mainly used as emulsifier and solubilizer in pharmaceutical preparations.
The solid product can be used as the carrier of solid dispersants, such as selepine, digoxin, digoxigenin, phenylbutazone, etc., which can greatly improve the solubility of these drugs and promote these drugs. absorption, the dosage is 2% to 10%. The preparation of solid dispersants by melting or solvent methods can greatly improve the dissolution rate and bioavailability of poorly soluble drug oral preparations. It is an ideal carrier for fast-acting solid dispersants.
Due to its non-toxicity, non-antigenicity, non-irritant, non-sensitizing, chemically stable and non-hemolytic properties, polyether polyol can be used as a synthetic emulsifier for intravenous injection. Poloxamer 188 is a good emulsifier for the preparation of intravenous fat emulsion, which can form a 0-van emulsifier, and the dosage is 0.1% to 0.5%. The dosage of this product is O. 2%, equivalent to 1% of soybean lecithin. The emulsion prepared with this crystal has small milk particles, high absorption rate, stable physical properties, and is not easy to delaminate, and can be sterilized by hot-pressing steam.
Polyether polyol can promote the absorption of drugs, and can also play the role of slow release and prolonged effect when used as a matrix. The listed products include griseofulvin cream, indomethacin suppository and aspirin suppository. Insulin is a polypeptide hormone synthesized by pancreatic B cells. It was artificially synthesized in my country in 1965 and is the first choice and necessary drug for diabetes treatment. Yun et al. used poloxamer as a matrix to prepare insulin suppositories. Animal experiments found that the hypoglycemic effect was greatly improved after adding this matrix. Another person obtained a series of suppositories containing deoxycholic acid, sodium taurocholine, etc., each containing 50 units of insulin, and administered rectally to diabetic rabbits, the hypoglycemic effect was equivalent to 56% of subcutaneous injection of 40 units of insulin, showing that Good bioavailability.
On the one hand, because polyether polyol slows intestinal peristalsis, the retention time of the drug in the gastrointestinal tract increases, and the absorption increases, thereby improving the bioavailability of oral preparations. On the other hand, it has good compatibility with the skin, increases skin permeability, and can promote the absorption of external drug preparations.
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Application Classification of Polyethylene-polypropylene Glycol
Polyethylene-polypropylene glycol are mainly made use of in the manufacture of soft, inflexible as well as semi-rigid polyurethane foams. Polyether polyol are not only easy to acquire basic materials, affordable, but also have excellent performance of the manufactured polyurethane foams. They are the largest polyol in the polyurethane foam sector. Alcohol resources. There are likewise some polyethers utilized in the production of polyurethane waterproof layers, polyurethane plastic runways, polyurethane elastomers, polyurethane finishings, polyurethane adhesives, polyurethane sealants, polyurethane footwear products and various other elastic non-foamed polyurethane products (referred to as instance products).
The polyether polyol utilized for adaptable foam are normally lengthy chain, low functionality polyethers. The capability of polyether polyol in the soft foam formulation is generally 2 to 3, as well as the ordinary molecular weight is in between 2000 and also 6500. The most pre-owned polyether triol in soft foam is typically glycerol (glycerol) as the initiator, which is gotten by the ring-opening polymerization of 1,2-propylene oxide or the copolymerization of propylene oxide and a small amount of ethylene oxide. Gotten, the molecular weight is generally 3000-7000. Polyether diols can be used as auxiliary raw materials to be combined with polyether triols in soft foam solutions. The soft foam polyether with the biggest quantity in the beginning is polyoxypropylene triol with a molecular weight of about 3000. The incurable hydroxyl teams of such polyethers are primarily second hydroxyl teams with low sensitivity. Later on, PO and EO copolyethers have basically been made use of. Polyethers with molecular weights of 3000-3500, containing a percentage of ethylene oxide chains and key hydroxyl groups are made use of for average thermal healing soft foams; polyethers with molecular weights of 5000-6500 and also high material of key hydroxyl teams (more than 70% in mole fraction) are commonly known as “high” Reactive polyether” is generally made use of for high-resilience soft foam, yet likewise for semi-rigid foam and various other foam products. This kind of polyether has great miscibility with water as well as isocyanate, suitable sensitivity, as well as significantly enhanced foam procedure stability. Additionally, the foam treating time is shortened, which also decreases the manufacturing expense.
Over the last few years, double steel cyanide complicated (DMC) catalytic systems have actually been utilized to create low unsaturation, high molecular weight polyether polyol at home as well as abroad. The high molecular weight polyether polyol created by this brand-new catalytic polymerization system has a molecular weight of even more than 10,000 and a slim molecular weight circulation range, which can be used for the production of soft foam and also minimize the amount of TDI.
High-functionality, high-hydroxyl value polyether polyols are typically made use of in inflexible foam formulas to give appropriate crosslinking as well as rigidness. The hydroxyl worth of the inflexible foam polyether polyol is normally 350-650 mg KOH/g, and also the ordinary capability is above 3. The basic hard foam formula is mostly utilized in a mix of two sort of polyethers, and also the typical hydroxyl worth is about 400mg KOH/g.
The polyether polyol with fragrant diamine compound as the beginning representative has faster curing in the later stage of frothing, and also the resulting foam has high strength and also reduced thermal conductivity. The cost of the initiator has a terrific impact on the manufacturing price of polyether polyol. Based upon cost factors, the majority of the general-purpose stiff foam polyether polyols utilize sucrose and also its mixtures as the beginning representative. Semi-rigid foam formulas usually make use of part of high molecular weight soft foam polyether, specifically high reactive polyether polyol, as well as part of high practical reduced molecular weight rigid foam polyether.
Polyurethane materials, including polyurethane water resistant coatings, flexible polyurethane plastic paths, polyurethane elastomers, polyurethane dipped layers, polyurethane adhesives, and polyurethane sealers, are commonly called situation products in the polyurethane sector according to the English abbreviation. Common polyether polyols made use of in CASE materials are polyether diols and polyether triols with molecular weights in the variety of 1000-3000. In addition, high molecular weight polyether triols are additionally made use of for sealers, and polyether triols with molecular weights of a number of hundred are likewise used for layers. ether polyols.
The low-unsaturation, medium- and also high-molecular-weight polyether manufactured by the new catalyst has a narrow molecular weight circulation and a functionality near the academic value. On the basis of low-unsaturation polyoxypropylene polyol, by adding ethylene oxide, high-performance polyether diols as well as triols with high primary hydroxyl material can be prepared, which are used in polyurethane microcellular elastomers, sealants, adhesives Agents, finishings as well as other fields. Compared with ordinary polyethers, the buildings of polyurethane products made from low-unsaturation polyether polyols such as strength and elongation are enhanced.
Application of Polyethylene-polypropylene Glycol
CN201410293236.9 discloses the application of poloxamer 188 in the medicine for preventing and treating Parkinson’s disease. The present invention finds that the administration of poloxamer 188 has a very good effect on the treatment of Parkinson’s disease, and no toxic and side effects are found in the therapeutic application; Because lysosomal damage is a common mechanism of many other organ lesions, it is inferred that poloxamer 188-maintaining cell lysosomal membrane integrity-cytoprotective pathway has a wide range of uses in other diseases.
CN201410765144.6 reported an erdosteine inhalation powder aerosol, which is actively inhaled in the form of ultrafine powder to directly deliver the drug to the lungs to take effect and overcome the degradation of the drug in the gastrointestinal tract. The liver first-pass elimination effect is low in bioavailability , by mixing erdosteine ultrafine powder and poloxamer 188 ultrafine powder, the mass ratio of erdosteine ultrafine powder is 20:3~2:1 The average particle size of erdosteine ultrafine powder is 1μm~5μm, and the maximum particle size does not exceed The average particle size of 10μm Poloxamer 188 ultrafine powder is 60μm~80μm and the maximum particle size is not more than 100μm. Preparation method: Grind erdosteine finely, and use an ultra-fine pulverizer for ultra-fine pulverization to obtain an ultra-fine powder with an average particle size of 1 μm to 5 μm. Use an ultra-fine pulverizer for ultra-fine pulverization of Poloxamer 188 to obtain an average particle size. Ultrafine powder with a diameter of 60μm~80μm; the pulverized ultrafine powder is mixed at a ratio of 20:3~2:1 and then packaged.
CN201610717445.0 discloses a preparation method of a nanometer oral protein drug delivery system based on polygalacturonic acid, which is prepared by using a W/O/W double emulsification method. First, polygalacturonic acid is dissolved in 4-6w /v% poloxamer 188 solution, and then add bovine insulin to dissolve to obtain the inner water phase; then use ethyl acetate as the oil phase, respectively use 18~22w/v% poloxamer 188 solution, dissolve the shell The 18~22w/v% poloxamer 188 solution of polysaccharide and the 18~22w/v% poloxamer 188 solution with chitosan and genipin dissolved are the outer aqueous phase solutions, and different nanometer oral solutions are prepared. Protein drug delivery systems. The nanometer oral protein drug delivery system of the invention is non-toxic, easily degradable, high in transport efficiency and high in absorption rate, and has high application prospects in the fields of oral transport research and application of protein drugs such as insulin, diabetes treatment, vaccine administration and the like .
- Polypropylene glycol – WikiPedia
- CN201410293236.9 Application of poloxamer 188 in the preparation of drugs for preventing and/or treating Parkinson’s disease
- Edited by Liu Yijun, Handbook of Polyurethane Raw Materials and Auxiliaries = NANDBOOK OF RAW MATERIALS AND ADDITIVES FOR POLYURETHANES, Chemical Industry Press, 2013.01, p.72
Polyethylene-polypropylene Glycol Suppliers and Manufacturers
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