Polyethylene Glycol CAS 25322-68-3 Poly(ethylene glycol) PEG
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Factory Supply Polyethylene Glycol CAS 25322-68-3 with Best Price
- Appearance: Colorless liquid
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Polyethylene Glycol Supplier & Manufacturer
Polyethylene Glycol: The Complete Guide
- Item 1: Basic Info of Polyethylene Glycol
- Item 2: What is Polyethylene Glycol?
- Item 3: Polyethylene Glycol Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of Polyethylene Glycol
- Item 6: Exactly What is Polyethylene Glycol Adjustment?
- Item 7: Quality Control of Polyethylene Glycol
- Item 8: Hot Sale Products
- Item 9: Get Polyethylene Glycol Quotation
Polyethylene Glycol for Sale
Basic Info of Polyethylene Glycol
Basic Info
Chemical Name: | Polyethylene Glycol |
Other Name: | Poly(ethylene glycol); PEG; Polyethylene glycol powder |
CAS: | 25322-68-3 |
EINECS: | 500-038-2 |
Type: | Food additives; Pharmaceutical raw materials; Organic raw materials; Inorganic salts; Cosmetic raw materials; Pharmaceutical intermediates |
Molecular Formula: | / |
Molecular Weight: | 0 |
Chemical Properties
Melting point | 64-66 °C |
Boiling point | >250°C |
density | 1.27 g/mL at 25 °C |
vapor density | >1 (vs air) |
vapor pressure | <0.01 mm Hg ( 20 °C) |
refractive index | n20/D 1.469 |
Fp | 270 °C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL, clear, colorless |
form | waxy solid |
color | White to very pale yellow |
Specific Gravity | 1.128 |
PH | 5.5-7.0 (25℃, 50mg/mL in H2O) |
Water Solubility | Soluble in water. |
Sensitive | Hygroscopic |
λmax | λ: 260 nm Amax: 0.6 |
Merck | 14,7568 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
Other Info
Brand Name: | Zhishang Chemical |
Provide: | Polyethylene Glycol MSDS; Polyethylene Glycol COA |
What is Polyethylene Glycol?
Polyethylene glycol (PEG), likewise known as polyethylene glycol ether, English name: Polyethylene Glycol CAS No. 25322-68-3, chemical architectural formula is HO (CH2CH2O) nH, it is based on ethylene oxide as well as water or ethylene glycol Alcohol is prepared by stepwise enhancement reaction as basic material, and also its basic material is generally derived from oil items.
As the level of polymerization boosts, the physical look and also buildings of polyethylene glycol gradually modification:
Those with a loved one molecular weight of 200-600 are fluid at space temperature, and also those with a relative molecular weight over 600 progressively come to be semi-solid. With the boost of molecular weight, it alters from a colorless and odor free viscous liquid to a waxy strong, as well as its hygroscopic capability reduces accordingly. It has the chemical residential or commercial properties of alcohol and can undertake esterification with fats to create esters. Soluble in water, ethanol and also different natural solvents. Steady to warm, acid and also alkali, and does not deal with several chemicals. Has excellent hygroscopicity, adhesion and also lubricity. Non-toxic as well as non-irritating. Harmless to people as well as animals.
Polyethylene glycol (PEG) has solid water absorption, it can absorb water from the air under typical temperature level problems, as well as the fluid can be miscible with water in any kind of proportion. It can be miscible with water in any kind of proportion. When the temperature is as high as the boiling point of water, the polymer will speed up. The precipitation temperature level depends upon the molecular weight as well as concentration of the polymer. Polyethylene glycol (PEG) is a non-ionic polymer and is secure under normal problems. It can oxidize with oxygen in the air at 120 ° C or greater. It is protected by inert gases such as co2 or nitrogen. 200 ~ 240 ℃ does not transform, when it rises to concerning 300 ℃, the molecular chain sector breaks and breaks down.
Polyethylene Glycol Uses
Typical polymer compounds in our daily life are typically insoluble in water, yet polyethylene glycol has a high solubility in water, due to the fact that the oxygen atoms in its particles will communicate strongly with water particles, which we call hydrogen bonding. When we put polyethylene glycol into water, each polyethylene glycol molecule will be thoroughly blended with several water molecules, so even polyethylene glycol particles with molecular weights as high as tens of thousands will remain in water. liquifies swiftly. Polyethylene glycol is not just extremely soluble in water, however likewise has superb solubility with several organic compounds. It is as a result of this special property that polyethylene glycol is widely made use of in numerous family chemicals such as cosmetics, toiletries and also toothpaste.
Among its main features is as a solvent or surfactant, helping to mix together parts with various chemical residential properties. At the same time, polyethylene glycol has a strong interaction with water, so the polyethylene glycol added to these items aids maintain it damp. Additionally, some day-to-day chemicals require a certain thickness, as well as polyethylene glycol comes in handy currently. Considering that low molecular weight polyethylene glycols are viscous liquids, they can considerably increase the viscosity of these day-to-day chemicals.
The Manager has Something to Say
This is William, CEO of Zhishang Chemical Co., Ltd.
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Application of Polyethylene Glycol
Clinical use
- Drug grade PEG is used as an excipient in many pharmaceutical products, consisting of oral, topical as well as parenteral dosage kinds.
- PEG is the basis of numerous laxatives, such as MiraLax. The whole intestine purging with polyethylene glycol as well as electrolyte is used for digestive tract prep work before surgery or colonoscopy.
- Polyethylene glycol is made use of to eliminate impaction and maintain therapy in youngsters with constipation.
- When connected to different protein medications or medication providers, polyethylene glycol of ideal size will reduce their elimination from the blood.
- Researchers examining outer nerve and also spine injury are exploring the opportunity that PEG can be made use of to fuse axons.
- Ma et al. have actually thought an example of PEG hydrogel in treatment (see Biological Makes use of). They recommend utilizing hydrogels to fix periodontitis (periodontal illness) by wrapping stem cells in gel that promote gum healing. The gel as well as enveloped stem cells will be injected right into the illness site and also cross-linked to produce the microenvironment required for stem cells to operate.
- Polyethylene glycol of adenoviruses for gene therapy can aid prevent negative responses caused by pre-existing adenovirus resistance.
- Both Moderna and also Pfizer BioNTech’s SARS CoV-2 vaccinations utilize PEGylated lipids as excipients. Both RNA injections are made up of carrier RNA or mRNA, covered in oily molecular bubbles called lipids. Each utilizes exclusive lipid innovation. In both vaccines, the bubbles are covered with secure particles of polyethylene glycol. By December 2020, some people were worried that PEG might create allergies. As a matter of fact, allergic reactions were the motoring element for the UK as well as Canadian regulatory authorities to issue recommendations, as well as pointed out that “2 individuals in the UK … received treatment and recuperated from anaphylactic shock”. As of December 18, the United States Centers for Disease Control and Avoidance stated that, within its territory, greater than 250000 vaccinations had actually videotaped 6 instances of “severe allergic reaction”, and also just one of the 6 situations had a “history of inoculation response”.
Chemical use
- The remains of Mary Rose from Karak in the 16th century, which were maintained and also treated with PEG in the 1980s.
- As PEG is a hydrophilic molecule, it has been made use of to passivate microscope slides to prevent non-specific bond of proteins in solitary particle fluorescence researches.
- Polyethylene glycol has reduced poisoning and also can be used in numerous items. The polymer is made use of as a lubricating covering on various surface areas in liquid and also non-aqueous environments.
- As PEG is an adaptable water-soluble polymer, it can be utilized to generate extremely high osmotic pressure (concerning lots of environments). It is additionally unlikely to interact particularly with biochemical substances. These features make PEG one of the most useful particles in the application of osmotic stress in biochemical as well as biofilm experiments, particularly in using osmotic stress and anxiety technology.
- Polyethylene glycol is additionally typically used as the polar fixed phase of gas chromatography and the warm transfer liquid in electronic screening tools.
- PEG is usually made use of to preserve water logged wood and other organic artifacts recovered from underwater historical environments, such as the battleship Vasa in Stockholm and also similar situations. It replaces water in wood products, supports timber dimensions, as well as prevents wood from warping or shrinking when dry.
- Additionally, PEG is used as a stabilizer to prevent shrinking when refining eco-friendly wood.
- Polyethylene glycol has been made use of to protect the tinted paintings of the Terra-cotta Warriors discovered at the UNESCO World Heritage Website in China. These painted social relics were produced in the age of Qin Shihuang (the first emperor of China). The pottery chips discovered during the excavation started to curl after being exposed to the completely dry air of Xi’an within 15 seconds. The paint will certainly then peel off in regarding four mins. The Bavarian State Security Workplace in Germany has developed a PEG preservative, which will assist safeguard the shade of clay soldiers when it is quickly applied to uncovered social relics.
- PEG is frequently made use of in mass spectrometry experiments (as an inner calibration compound), and its unique fragmentation setting can achieve precise and repeatable adjusting.
- Polyethylene glycol derivatives, such as narrow variety ethoxylates, are made use of as surfactants.
- PEG has actually been utilized as a hydrophilic block of amphiphilic block copolymers to create some polymer blisters.
- Polyethylene glycol is a component of the propellant made use of in the UGM-133M Trident II rocket offered by the United States Navy.
Biological usage
- PEG can be customized and also cross-linked right into hydrogels, as well as utilized to mimic the extracellular matrix (ECM) environment for cell encapsulation and also study.
- An instance research was performed making use of PEG diacrylate hydrogel to reconstruct the vascular setting by covering endothelial cells as well as macrophages. This model additionally promotes the modeling of vascular diseases and also the isolation of macrophage phenotype on blood vessels.
- Polyethylene glycol is normally used as a crowding representative in vitro experiments to mimic extremely crowded cell problems.
- PEG is generally utilized as a precipitant for plasmid DNA splitting up and also healthy protein crystallization. X-ray diffraction of protein crystal can reveal the atomic framework of healthy protein.
- Polyethylene glycol is utilized to fuse 2 different kinds of cells, the most typical being B cells as well as myeloma, to generate hybridoma. C é sar Milstein as well as Georges JF K ö hler created this modern technology. They utilized it in antibody production and also won the Nobel Prize in Physiology or Medication in 1984.
- The polymer chain segment originated from PEG polyol offers polyurethane flexibility, which is used in applications such as elastic fiber (spandex) as well as foam pad.
- In microbiology, PEG rainfall is utilized to focus viruses. PEG is also utilized to induce full fusion (mixing of internal and also external wattles) in reconstituted liposomes in vitro.
- Gene therapy vectors (such as infections) can be coated with PEG to shield them from inactivation of the body immune system and eliminate them from organs that may collect and create toxic effects.
- The size of PEG polymers has verified to be crucial, and larger polymers supply optimal immune defense.
- Polyethylene glycol is a component of secure nucleic acid lipid fragments (SNALP) used to package siRNA for usage in benefactors.
- In blood banks, PEG is made use of as a booster to boost antigen and also antibody detection.
- When phenol is made use of busy setting, PEG 300 can be utilized for phenol skin burns to inactivate any type of residual phenol.
- n biophysics, polyethylene glycol is the recommended particle for the research study of the size of functional ion networks, because they have a spherical form in aqueous service as well as can obstruct the conductivity of ion networks.
Commercial use
- PEG is the basis of many skin creams (such as cetopolysol) and also personal lubricating substances (often used in combination with glycerin).
- Polyethylene glycol is utilized as a dispersant in several tooth pastes. In this application, it incorporates with water as well as aids to keep xanthan gum uniformly dispersed throughout the toothpaste.
- PEG is also being studied for bullet evidence garments as well as tattoos for keeping track of diabetes mellitus.
- In reduced molecular weight formulations (such as PEG 400), it is utilized as an ink solvent and also lubricant for print heads in Hewlett Packard designjet printers.
- Polyethylene glycol is additionally utilized as a defoamer in food and drinks – its INS number is 1521 or the EU E1521.
Industrial use
- Spear II submarine launched ballistic missile strong rocket fuel uses a nitrate ester plasticized polyethylene glycol (NEPE-75).
- Dimethyl ether of PEG is the key part of Selexol, which is the solvent made use of to get rid of carbon dioxide and hydrogen sulfide from the artificial gas stream in the coal-fired incorporated gasification mixed cycle (IGCC) power plant.
- PEG has been utilized as a gateway insulator in electric double layer transistors to induce superconductivity in the insulator.
- Polyethylene glycol is additionally used as the polymer body of strong polymer electrolyte. Although it has actually not yet been taken into commercial manufacturing, many groups around the world are taken part in the research study of solid polymer electrolytes including PEG, in order to enhance their performance and allow their application in batteries, electrochromic display screen systems and other items.
- PEG is infused into the industrial process to decrease foam in the separation devices.
- Polyethylene glycol is made use of as a glue for preparing commercial porcelains.
- PEG is utilized as additive of silver halide photographic solution.
Enjoyment use
- PEG is made use of to increase the size as well as toughness of large soap bubbles.
- Polyethylene glycol is the primary component of many individual lubricating substances. (Do not confuse it with propylene glycol).
- Polyethylene glycol is the major component of pigment (called “filler”) in paintball.
Exactly What is Polyethylene Glycol Adjustment?
Chemical modification of polyethylene glycol is to chemically combine polyethylene glycol polymer chains to protein molecules. By enhancing the size of the medicine molecule, it can successfully lengthen its half-life in vivo, and also at the same time shield its immune site to dramatically decrease immunogenicity. It is worldwide recognized as one of one of the most efficient long-acting healthy protein solution technologies.
Polyethylene glycol (PEG) is a neutral, safe, high molecular polymer with distinct physicochemical residential properties and great biocompatibility. It is also among the few synthetic polymers accepted by the FDA that can be made use of for in vivo injection. Polyethylene glycol, or PEG, is very hydrophilic, has a huge hydrodynamic quantity in aqueous remedy, and also is not immunogenic. When combined to a drug molecule or medication surface area, its exceptional residential properties can be conveyed to the customized medication particles, changing their biodistribution actions and solubility in aqueous options, creating a steric obstacle around their modified medicines, lowering the chemical task of the medicine solution, stay clear of quick removal in the metabolism of the kidney, and allow the drug to be acknowledged by cells of the immune system; the PEG modifications introduced by Zhongpeptide include:
( 1) PEG2, PEG4, PEG8, PEG12, PEG24
( 2) PEG2000, PEG5000, PEG3400
( 3) PEG20K, PEG40K
Reference
- Polyethylene glycol – WikiPedia
- “Polyethylene Glycol as Pharmaceutical Excipient”. pharmaceutical.basf.com.
Polyethylene Glycol Supplier and Manufacturer
As a polyethylene glycol supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best polyethylene glycol raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have demand for polyethylene glycol and related products, please contact our service staff Zhishang Chemical – White directly, we will provide you with high-quality products at the best price.
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FAQ
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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
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Different quantity has different discount.
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1. ≤50kg, Express delivery recommended, usually called as DDU service;
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3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
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Quality Control of Polyethylene Glycol
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