Model No.: X-CAS 486-66-8
Certification: ISO, FDA, HACCP
Assay Method: HPLC-MS, GPC, HPLC
Application Form: Capsule
Application: Food, Health Care Products, Medicine
Extract Source: Other
CAS No.:: 486-66-8
Grade: Synthetic Perfume, Chemicals
Appearance: Yellow Crystalline Solid
Bp:: 512.8ºC At 760 MmHg
Packaging: in 25kg drum
Productivity: 10000kg per month
Place of Origin: Shandong, China (Mainland)
Supply Ability: in stock
Certificate: ISO CE
HS Code: 486-66-8
CAS NO 486-66-8 Daidzein
The binding reaction between daidzein and human serum albumin (HSA) was studied by fluorescence quenching spectroscopy, synchronous fluorescence spectroscopy and UV-Vis absorption spectroscopy. Daidzein has a strong fluorescence quenching effect on human serum albumin, the quenching mechanism belongs to static quenching, and intramolecular non-radiative energy transfer occurs. Using the Stern-Volmer equation to process the experimental data, the binding constants KA between daidzein and HSA were 0.34 × 104 (23 ℃), 1.10 × 104 (30 ℃) and 4.36 × 104 L · mol – 1 (40 ° C). According to F? Rster non-radiative energy transfer theory, the binding distance between daidzein and HSA was found to be 1.50 nm (23 ℃), 1.46 nm (30 ℃) and 1.42 nm (40 ℃) . By calculating the corresponding thermodynamic parameters, we can see daidzein interaction with human serum albumin is a spontaneous process of Gibbs free energy reduction, and the main force between the two types of hydrophobic force, while using synchronous fluorescence Spectra were used to investigate the effect of daidzein on the conformation of HSA.
Experiments show that daidzein fluorescence quenching of HSA belongs to the static quenching mechanism, and intramolecular non-radiative energy transfer occurs; the two mainly by the hydrophobic force combination, the binding site close to the Trp residues in HSA, After binding, the polarity of the microenvironment in which the Trp residues are located slightly decreases, resulting in a change in the conformation of HSA.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light.
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