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Phentolamine Mesilate CAS 65-28-1

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Phentolamine Mesilate Supplier & Manufacturer

Basic Info

What is Phentolamine Mesilate?

Phentolamine mesilate (Phentolamine mesylate) is also known as benzamidoline mesylate, Regitine, chemical name: 3-[[(4,5-dihydro-1H-imidazol-2-yl ) methyl] (4-methylphenyl) amino] phenol mesylate, phentolamine mesylate is an α-receptor blocking drug, by blocking α-receptors and indirectly stimulating β-receptors, rapidly Dilate peripheral blood vessels, significantly reduce peripheral vascular resistance, increase peripheral blood volume, and improve microcirculation. Phentolamine mesylate has an excitatory effect on the heart, increasing myocardial contractility, heart rate, and cardiac output. It is mainly used clinically for the treatment of acute heart failure with pulmonary congestion or pulmonary edema, vasospasm disease, cyanosis of the hands and feet, sensuous toxic shock and diagnostic tests for pheochromocytoma, etc. It is also used for premature ventricular beats. Male sexual dysfunction (ED) and female frigidity.

There are multiple synthetic methods of phentolamine mesylate reported in the literature at present, such as condensation of 3-hydroxyl-4-methyldiphenylamine and chloromethylimidazoline hydrochloride in xylene to obtain the crude product of phentolamine hydrochloride , and then use chloroform-ethanol to mix the solvent essence to obtain phentolamine, which becomes mesylate in absolute ethanol, and crystallizes after concentration. However, due to the high toxicity of xylene and high boiling point, and the phentolamine hydrochloride needs to be refined before being used in the next step reaction, the mesylate needs to be concentrated in a solvent for crystallization, the process is complicated, and the yield is low. The method of dissolving phentolamine in water and passing through a silica gel chromatography column, and adjusting the pH value with ammonia water is relatively irritating to the human body, and the industrial production operation is difficult, which is not suitable for large-scale industrial production needs.

Phentolamine Mesilate Uses

  1. Phentolamine mesylate is a short-acting non-selective α-receptor (a1, a2) blocker, which can antagonize the effects of adrenaline and norepinephrine in blood circulation, dilate blood vessels and reduce peripheral vascular resistance.
  2. Annoying the result of catecholamines, it is made use of in the diagnosis as well as treatment of pheochromocytoma, however it has little effect on the blood pressure of typical individuals or clients with crucial high blood pressure.
  3. It can reduce peripheral vascular resistance, reduce cardiac afterload, decrease left ventricular end-diastolic pressure and pulmonary artery pressure, increase cardiac output, and can be used to treat heart failure. Carcinogenic, mutagenic and toxic to reproduction.
  4. Long-term tests have shown that phentolamine mesylate has no obvious carcinogenic, mutagenic and reproductive toxicity. In experiments on rats, mice and rabbits, phentolamine mesylate was not found to be teratogenic or embryogenic.

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This is William, CEO of Zhishang Chemical Co., Ltd.

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Medicine Interactions

  • Combined with sympathomimetic amines, the latter’s peripheral vasoconstriction can be counteracted or weakened. Sedative and hypnotics such as phenobarbital and glutimide, and antihypertensive drugs such as reserpine and Jiangyaling can strengthen the antihypertensive effect of this drug. When used in combination with cardiac glycosides, it can increase its toxicity.
  • When used in combination with guanethidine, the incidence of orthostatic hypotension or tachycardia is high.
  • Combined with diazoxide, the effect of diazoxide on inhibiting insulin release is inhibited.
  • Avoid using it in combination with iron supplements.
  • Do not use in combination with nitroglycerin drugs.

Phentolamine Mesylate Dosing Instructions

  1. Low blood pressure, severe arteriosclerosis, angina pectoris, myocardial infarction, renal insufficiency, gastritis, gastric and duodenal ulcers are contraindicated.
  2. When treating toxic shock and severe pneumonia, it is advisable to replenish blood volume at the same time.
  3. Combined use of phenobarbital, glutimide, methaqualone, and reserpine in the diagnostic test for pheochromocytoma can produce false positives.
  4. Isoproterenol can be used to deal with overdose.
  5. Avoid compatibility with iron.
  6. Combined with dopamine or dobutamine, the heart rate can be significantly accelerated; combined with adenosine triphosphate, it can antagonize the effect of adenosine, so this product should not be used in combination with adenosine or drugs that expand coronary arteries through adenosine.
  7. When used in combination with cardiac glycosides, the toxicity can be enhanced.

References

  1. Phentolamine instructions
  2. Phentolamine mesylate – PubChem

Phentolamine Mesylate Supplier and Manufacturer

As a phentolamine mesylate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best phentolamine mesylate raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for phentolamine mesylate and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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