Pentafluoropropionic acid CAS 422-64-0

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  • Appearance: Cololrless liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Pentafluoropropionic acid Supplier & Manufacturer

Basic Info

What is Pentafluoropropionic acid?

Pentafluoropropionic acid is an organic emulsion with a chemical formula of C3HO2F5 and is a tintless liquid.

Pentafluoropropionic acid can be used as a fluorine- containing alkylating agent in the fields of fluorine- containing drugs and fluorine- containing fungicides. At the same time, the downstream products of pentafluoropropionate are veritably rich, similar as the synthesized pentafluoropropanol, which can be used in the field of electronics and perfection instruments This kind of fluorine- containing peroxide generator has the advantages of low inauguration temperature, many by- products, perfluorinated substituent groups at the end, and good stability. It’s an essential generator for the medication of high- chastity fluorine- containing polymers. thus, the product of pentafluoropropionic acid has certain profitable value.

Pentafluoropropionic acid Uses

Perfluoropropionic acid is used for the analysis of gentamicin using a Gemini column by liquid chromatography (LC) method.

Pentafluoropropionic acid is used as an efficient catalyst for β- The condensation reaction of naphthol with aryl aldehydes to prepare dibenzo [a, j] xanthone.

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Application of Pentafluoropropionic acid

Preparation of Pentafluoropropionic acid

A co-production process of hexafluoroisopropyl methyl ether and pentafluoropropionic acid:

  1. Weigh 32g of methanol into a 250mL round bottom flask, add 8.1g of sodium methoxide into the round bottom flask and stir until fully dissolved to obtain a sodium methoxide methanol solution.
  2. Weigh 31.6g of perfluoro-2-methyl-2,3-epoxypentane into the sodium methoxide methanol solution in step 1), seal the round bottom flask, and place it in a cold bath at 0°C , with 700r/min stirring reaction 2h, obtain the mixture containing product.
  3. Filter the product of step 2 to remove insoluble salts, add deionized water to the filtrate and wash 3 times to remove methanol, and the washing liquid is separated and rectified to obtain hexafluoroisopropyl with a purity of 99.5%. Methyl ether and methyl pentafluoropropionate.
  4. Add 400 mL of sulfuric acid with a concentration of 1 mol/L to methyl pentafluoropropionate, stir at 60°C for 3 hours, and rectify at the end of the reaction to obtain pentafluoropropionic acid with a purity of 99%.

The process of co-producing pentafluoropropionic acid with hexafluoroisopropyl methyl ether uses methoxy alkali metal salt and perfluoro-2-methyl-2,3-epoxypentane as main raw materials, under the condition of alcohol solvent Carry out ring-opening alkylation reaction to obtain hexafluoroisopropyl methyl ether and pentafluoropropionic acid at the same time, avoiding the expensive raw material of hexafluoroisopropanol in the prior art and the highly toxic dimethyl sulfate as an alkylation reagent, etc. The problem is that the process route is simple, and both the main product and the by-product have economic value and are suitable for industrial application.


  1. Perfluoropropionic acid – WikiPedia
  2. [Chinese invention] CN202011082609.X A co-production process of hexafluoroisopropyl methyl ether and pentafluoropropionic acid

Pentafluoropropionic acid Supplier and Manufacturer

As a pentafluoropropionic acid supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best pentafluoropropionic acid raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for pentafluoropropionic acid and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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