Palmitic Acid CAS 57-10-3

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Palmitic Acid Supplier & Manufacturer

Basic Info

What is Palmitic Acid?

Palmitic acid (PA) is also called hexadecanoic acid, and its molecular formula is CH3(CH2)14COOH. Found in palm oil, Japanese wax, Chinese vegetable oil and catalpa seed oil. It is currently generally believed that the occurrence and development of NAFLD may be caused by the excessive accumulation of free fatty acids in plasma, especially saturated fatty acids, of which palmitic acid is one of the important members of the saturated fatty acid family. Current research shows that palmitic acid can cause oxidative stress in cells by damaging the normal function of the mitochondrial oxidative respiratory chain. On the other hand, studies have confirmed that PA-activated NOX4 is involved in the insulin resistance of hepatocytes and the damage and dysfunction of endothelial cells, and leads to the inflammatory response of hepatocytes by promoting the release of IL-8. Whether excessive accumulation of palmitic acid in hepatocytes can lead to oxidative stress by activating NOX4 during the development of NAFLD, and whether it can activate inflammasomes through oxidative stress to increase the production of the inflammatory factor IL-1β in hepatocytes, There is currently a lack of relevant research and discussion.

Palmitic acid, as a long-chain saturated fatty acid, is an important component of blood lipids and is involved in the occurrence of NAFLD. Under normal circumstances, mitochondria can decompose excess fatty acids in cells through fatty acid β-oxidation and produce ATP for energy. At the same time, the electronic respiratory chain also produces a certain amount of ROS. The excessive production of ROS will cause damage to the structure and function of mitochondria, impair the function of the electronic respiratory chain, further enhance the cellular oxidative stress response, and lead to dysfunction of fatty acid decomposition, causing fatty acids to be deposited in the cytoplasm, which plays a role in the role of PA. Under the condition, obvious fat particle deposition was seen in hepatocytes, and total cellular ROS and mitochondrial-derived ROS production increased significantly, confirming that PA can induce mitochondrial oxidative stress and lead to hepatocyte steatosis.

Palmitic Acid Uses

Simple ester of palmitic acid, mainly used in the plastics industry. Its alkali metal salt is soluble in water and has decontamination effect. It is one of the main ingredients of soap and soap. Other metal salts are insoluble in water and are used in lubricants, pharmaceutical industry, cosmetics, and waterproofing and bactericides. The main source of palmitic acid is oil, which is obtained by saponifying and acidifying oil and then separating it.

Mainly used as surfactant. When used as nonionic, it can be used in polyoxyethylene sorbitan monopalmitate and sorbitan monopalmitate. The former is made into a lipophilic emulsifier and is used in all cosmetics and Medicine, the latter can be used as emulsifier in cosmetics, medicine, food, dispersant of pigment ink, and also used as defoaming agent; when used as anionic type, it can be made into sodium palmitate and used as raw material for fatty acid soap, plastic emulsifier etc.; zinc palmitate is used as a stabilizer for cosmetics and plastics; in addition to being used as a surfactant, it is also used as a raw material for isopropyl palmitate, methyl ester, butyl ester, amine compounds, chlorides, etc. Among them, isopropyl palmitate Propyl ester is a cosmetic oil phase raw material and can be used to make lipsticks, various creams, hair oils, hair creams, etc.; others such as methyl palmitate can be used as lubricating oil additives, surfactant raw materials; PVC slip agents, etc.; Raw materials for candles, soaps, greases, synthetic detergents, softeners, etc.; used as spices, which are edible spices allowed in my country’s GB2760-1996; also used as food defoaming agents.

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Application of Palmitic Acid

Palmitic acid is used as a raw material in the production of candles, soaps, greases, softeners and synthetic detergents. Palmitic acid is used to make odorless chloramphenicol and various palmitic acid metal salts. Its sodium or potassium salts can be used as emulsifiers in emulsion polymerization. Aluminum salts and zinc salts are used in lubricants, coatings, oil blacks and thickeners. Among plasticizers, this product has a special aroma and taste. According to my country’s GB2760-89 regulations, it can be used to prepare various edible spices and is also used as a raw material for defoaming agents and other food additives.

  • Application 1. CN202010414673.7 discloses a method for preparing chloropalmitic acid methyl ester plasticizer using palmitic acid. It uses palmiated oil as raw material. First, the palmitic oil is subjected to three steps of esterification, alcoholysis and distillation. The synthesis of palm fatty acid methyl ester is completed. The free fatty acids contained in the palmiated oil are synthesized and converted into palm fatty acid methyl ester. The fatty acid glycerides contained in the palmiated oil are also synthesized and converted into palm fatty acid methyl ester; the obtained palm fatty acid methyl ester is The ester is distilled under normal pressure and high temperature to refine palm fatty acid methyl ester; then turn on the chlorine gas to synthesize the chlorinated palm fatty acid methyl ester plasticizer. After the reaction is completed, the hydrogen chloride is removed to obtain the chlorinated palm fatty acid methyl ester plasticizer. agent. The prepared chlorinated palm fatty acid methyl ester plasticizer has the characteristics of environmental protection, low cost, stable quality, and good compatibility with polyvinyl chloride, and can replace chlorinated paraffin, DOP, and DOTP in large quantities.
  • Application 2. CN201811151765. Leakage, technical problems that cannot meet actual engineering needs. The specific steps of the method are: heating, melting and mixing decanoic acid and palmitic acid to obtain a decanoic acid-palmitic acid dibasic fatty acid eutectic mixture; drying expandable graphite and then subjecting it to microwave treatment to obtain expanded graphite; combining expanded graphite with The decanoic acid-palmitic acid dibasic fatty acid eutectic mixture is heated and stirred at regular intervals, so that the decanoic acid-palmitic acid dibasic fatty acid eutectic mixture is evenly adsorbed into the pores of expanded graphite to obtain decanoic acid-palmitic acid/expanded graphite. Graphite composite phase change material. The decanoic acid-palmitic acid/expanded graphite composite phase change energy storage material obtained by this method has significant phase change heat storage capacity and thermal conductivity, good thermal stability, is not suitable for leakage, and is suitable for the field of building energy conservation.

The Difference between Palmitic Acid, Stearic Acid and Fatty Acids


  1. Palmitic acid – WikiPedia
  2. CN201810726500.1 Preparation method of trisaturated fatty acid glyceride
  3. Xu Wen, Guo Yubin, Li Xu, et al. Palmitic acid activates inflammasome through hepatocyte oxidative stress response[J]. Journal of Southern Medical University

Palmitic Acid Supplier and Manufacturer

As a palmitic acid supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best palmitic acid raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for palmitic acid and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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