Oxalyl Chloride CAS 79-37-8
Factory Supply Oxalyl Chloride CAS 79-37-8 with Best Price
- Appearance: Colorless liquid
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: Oxalyl Chloride Supplier & Manufacturer
Oxalyl Chloride: The Complete Guide
Oxalyl Chloride for Sale
Ethyl oxalyl chloride; Methyl oxalyl chloride
Organic raw materials; Pesticide intermediates; Material intermediates and auxiliaries
What is Oxalyl Chloride?
Oxalyl chloride is a synthetic intermediate for medicines, pesticides, coatings, etc. It is used as a raw material for synthesizing antibiotics in medicine, as a raw material for methacrylic phthalocyanate in coatings, and for the synthesis of ultra-efficient sulfonylureas in the pesticide industry. Herbicide benzsulfuron, plant growth regulators, etc., are widely used.
Oxalyl chloride is a relatively active acylating agent and amidating agent, which can be used for the acylation of acids or amines to prepare a variety of pesticides, fungicides, pharmaceutical antitumor agents, X-ray contrast agents, etc. It can also be used as chlorinating agent, carbonylation activator, crosslinking agent for chlorocarbonylation agent, it can also carry out cyclic polycondensation reaction, esterification reaction, etc. It is used in industries such as plastics, polyesters and polyurethanes. Oxalyl chloride is used as an etchant for semiconductor materials in industry. In conclusion, oxalyl chloride is an important raw material for multi-purpose fine chemical products.
Oxalyl Chloride Uses
- Normally used as a poison gas for armed forces usage, and additionally as a chlorinating representative in organic synthesis Analytical reagents.
- Oxalyl chloride is used to prepare cardiolipin analogues that induce peroxidase activity by cytochrome C. It is also used to prepare fluorescent indicator of cytosolic calcium.
- It is an important carboxylic acid derivative, which has important applications in organic synthesis, drug synthesis, etc. It can mainly undergo hydrolysis, alcoholysis, ammonia (amine) hydrolysis, reaction with organometallic reagents, reduction Hydrohalogenation and other reactions.
- Oxalyl chloride is an intermediate or reagent for organic synthesis of pesticides, medicines and coatings. It can be used in pesticides to synthesize sulfonylureas, herbicides benzsulfuron, plant growth regulators, etc.; in medicines, it can be used to synthesize cephalosporins Pu or cefuroxime axetil; in coatings, it can be used to prepare methacryloyl isocyanate, etc.; it is often used to prepare other acid chlorides in laboratories or factories, and it has a wide range of uses.
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Reaction Mechanism of Oxalyl Chloride
Oxalyl chloride is the most active acylating reagent, a resonance hybrid of the limiting structure.
This resonance effect stabilizes the entire molecule and also strengthens the bond between the carbonyl carbon atom and the leaving group. The resonance effect is a stabilizing effect that relies on the overlapping of the bonding atomic orbitals, and acid chlorides may be least affected by this resonance, fatty acids (including unsaturated fatty acids), aromatic acids, organic sulfonic acids and substituted acids (such as amino acids) and halogenated acids, etc.) can generate acid chloride with thionyl chloride in the presence of a catalyst, and the catalyst usually uses N,N-dimethylformamide (DMF), N,N-dimethylaniline and pyridine.
Resolve Resolution of Oxalyl Chloride
The German patent introduces that oxalic acid and phosphorus pentachloride react in phosphorus oxychloride in the presence of triethylamine to obtain oxalyl chloride, and the yield can reach 73%.
Domestic production example: in a 2L four-necked flask with a stirrer, a solid raw material supply funnel and a distillation device, 1kg of phosphorus pentachloride and 12g of triethylamine are suspended in 500g of phosphorus oxychloride, and at a reaction temperature of 60° C. and Under the pressure of 2.5kPa, 100g of water-free oxalic acid was supplied for 40min, and finally stirred at 70°C and 2.5kpa for 30min. During the supply and stirring, in the distillation apparatus, we obtained: w=20.7% oxalyl chloride and w=78.4% trichloride Phosphorus oxide mixture 4979, unreacted phosphorus pentachloride 589 and added triethylamine and residual phosphorus oxychloride in the reactor. In terms of oxalic acid, the yield is 73%; in phosphorus pentachloride, the yield is 80%.
- Oxalyl chloride – WikiPedia
- Dondoni, A.; Perrone, D. (2004). “Synthesis of 1,1-Dimethyl Ethyl-(S)-4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate by Oxidation of the Alcohol”. Organic Syntheses.; Collective Volume, vol. 10, p. 320
Oxalyl Chloride Suppliers and Manufacturers
As a oxalyl chloride supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best oxalyl chloride raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
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