
o-Phenanthroline CAS 66-71-7



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- Appearance: White powder
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
- Zhishang Chemical: o-Phenanthroline Supplier & Manufacturer
o-Phenanthroline: The Complete Guide
- Item 1: Basic Info of o-Phenanthroline
- Item 2: What is o-Phenanthroline?
- Item 3: o-Phenanthroline Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of o-Phenanthroline
- Item 6: Reference
- Item 7: Quality Control of o-Phenanthroline
- Item 8: Hot Sale Products
- Item 9: Get o-Phenanthroline Quotation
o-Phenanthroline for Sale
Basic Info of o-Phenanthroline
Chemical Name: | o-Phenanthroline |
Other Name: | 1,10-Phenanthroline anhydrous; 1,10-Phenanthroline; Ortho-phenanthroline |
CAS: | 66-71-7 |
EINECS: | 200-629-2 |
Type: | Pharmaceutical intermediates; Organic raw materials |
Molecular Formula: | C12H8N2 |
Molecular Weight: | 180.21 |
Melting point | 114-117 °C(lit.) |
Boiling point | >330°C |
density | 1.1836 (rough estimate) |
refractive index | 1.5200 (estimate) |
Fp | >330°C |
storage temp. | Store below +30°C. |
solubility | 2.69g/l |
form | Powder |
pka | 4.84(at 25℃) |
color | White to light yellow or light pink |
Water Solubility | slightly soluble |
Sensitive | Hygroscopic |
Stability: | Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents. |
Brand Name: | Zhishang Chemical |
Provide: | o-Phenanthroline MSDS; o-Phenanthroline COA |
What is o-Phenanthroline?
O-phenanthroline is an organic compound with molecular formula C12H8N2. The solid is white crystal and dissolves in water to form a light yellow to yellow solution. When recrystallized with water, it contains a crystal water molecule. The o-phenanthroline hydrate is a white crystal. When recrystallized with benzene, there is no crystal water, and the melting point is 98-100 ℃ (117 ℃). The boiling point is above 360 ℃. Soluble in ethanol, benzene and acetone, insoluble in petroleum ether. It forms complexes with iron, copper, cobalt, nickel and 2,2-BIPYRIDINE, forms red complexes with Fe2 +, and oxidizes with potassium permanganate to obtain 2,2-bipyridine-3,3 ‘- dicarboxylic acid.
O-phenanthroline is a common redox indicator. It is a bidentate heterocyclic compound ligand, similar to 2,2-BIPYRIDINE. It is a common auxiliary ligand in the construction of crystal materials. It has a strong chelating property and can form very stable complexes with most metal ions. It can be used as a quantitative colorimetric reagent for copper and iron, and also as an indicator for cerium sulfate titration of iron salts; It can also be used as a dye for animal fibers.
O-phenanthroline can form facilities with different transition metals. Given that the complicateds created are chelate complexes, they are fairly steady. The complicateds and also their by-products formed with copper can be used as non-oxidative nucleic acid cleaving enzymes because they have particular cleavage activity on DNA, and also further have specific anticancer tasks.
o-Phenanthroline Uses
O-phenanthroline is a typical ligand for spectroscopic decision of steels and also spectroscopic evaluation of CO2 reduction. It is used for the cross-linking response of organic boronic acid catalyzed by Cu(II), etc. It can also be used as a redox sign as well as a reagent for the decision of ferrotitanium.
It forms facilities with iron, copper, cobalt, nickel as well as 2,2′-bipyridine, forms red facilities with Fe2+, as well as is oxidized with potassium permanganate to acquire 2,2′-dipyridyl-3,3′-dicarboxylate acid. It can be used as a measurable colorimetric reagent for copper as well as iron, and as an indication for titrating iron salts with cerium sulfate; it can likewise be used as a dye for pet fibers. The o-phenanthroline-Fe(II) indicator can be prepared by liquifying 1.485 g of o-phenanthroline monohydrate and 0.695 g of FeSO4-7H2O in 100 mL of water. Indicator for ceric sulfate titration of iron salts. A related ligand is red phenanthroline (BPT), 4,7-diphenyl-1,10-phenanthroline. O-phenanthroline can likewise be used for the analysis of the material of alkyl lithium substances. The details steps are to make the example react with a small amount (about 1 mg) of o-phenanthroline to provide a dark shade, and after that titrate with alcohol till the colorless titration end point is reached.
In the solution of pH=2 ~ 9, o-phenanthroline responds with divalent ferrous ion (Fe2+), the selectivity of this reaction is very high, and also the resulting orange-red complex is extremely secure, lgK stable = 21.3 (20 ° C), its option has an optimum absorption top at 510nm (visible light), as well as this shade reaction can be made use of to establish trace iron by visible light spectrophotometry.
The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.
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If you want to buy o-phenanthroline, pls contact us to get a free quote.
Application of o-Phenanthroline
Synthesis of 2-hydroxy-1,10-o-phenanthroline
Starting with l,10-phenanthroline, and then adding structural modifications on this basis, it is an important method to synthesize l,10-phenanthroline derivatives. The derivatives obtained in this way are mainly concentrated in 5, The 6-position, 3,8-position, 2,9-position, and the 5,6-position produced the highest number of derivatives. Derivatives of phenanthroline, as good metal ligands, are widely used in antibacterial and antitumor, catalytic reactions, supramolecular chemistry, DNA probes, molecular switches, etc. 2-Hydroxy-1,10-o-phenanthroline is an important 2-position derivative in 1,10-o-phenanthroline derivatives. The main synthesis method is through 2-halogenated-1,10-o-phenanthroline. The hydrolysis reaction is obtained. Due to the lack of access routes, there are relatively few studies on the properties and applications of 2-hydroxy-1,10-phenanthroline reported in the literature. CN201710460068.1 provides a kind of synthetic method of 2-hydroxyl-1,10-o-phenanthroline, and increases the source route of target product. For this reason, the present invention adopts the following route to synthesize 2-hydroxy-1,10-o-phenanthroline:
The reaction method takes 1,10-o-phenanthroline (2) as a starting material, reacts with benzyl halide to obtain an intermediate quaternary ammonium salt (3), and then oxidizes it with potassium ferricyanide to obtain 1-benzyl-1,10 -o-phenanthroline-2-one (4), then debenzylated under palladium-carbon catalysis to obtain 2-hydroxy-1,10-o-phenanthroline (1).
The preparation scheme of 2-hydroxy-1,10-o-phenanthroline is as follows: 1,10-o-phenanthroline (2) and benzyl halide are heated to obtain 1-benzyl-1,10-o-phenanthroline halide salt (3 ), 1-benzyl-1,10-o-phenanthroline halide salt (3) was oxidized by potassium ferricyanide in cold aqueous solution to obtain 1-benzyl-1,10-o-phenanthroline-2-one (4) ), and finally low-pressure hydrogenation in the presence of palladium-carbon catalyst to obtain 2-hydroxy-1,10-o-phenanthroline (1). The benzyl halide used in this scheme can be selected from benzyl chloride or benzyl bromide, and can also be a derivative of benzyl chloride or benzyl bromide; it is better to control the temperature at -5 to 5°C when potassium ferricyanide is oxidized; The hydrogen pressure in the case of the benzyl group may be normal pressure or a hydrogen pressure not higher than 1 MPa.
CN201410517030.X provides an organic-silica gel hybrid capillary monolithic column modified by o-phenanthroline and its application. The organic-silica gel hybrid capillary monolithic column not only eliminates the complicated and tedious operations such as traditional packing column packing, and sintered plugs It also overcomes the shortcomings of low open-column capacity and small comparison, and its chemical properties are stable, reproducible, and have more sites of action with the sample. Good separation effect. In order to achieve the above object, the present invention adopts the following technical scheme: an organic-silica gel hybrid capillary monolithic column modified by o-phenanthroline, using o-phenanthroline as an ionic liquid, subjected to capillary pretreatment, column bed preparation, and column bed modification The organo-silica hybrid capillary monolithic column was prepared.
Its preparation method comprises the following steps:
- Capillary pretreatment: take a capillary column of appropriate length, pass water for 0.5 h, 1 M hydrochloric acid for 1 h, water for 0.5 h, and 1 M sodium hydroxide for 0.5 h, plug both ends and react at 100 °C for 3 h; Water for 0.5 h, 0.1 M hydrochloric acid for 0.5 h, water for 0.5 h, methanol for 0.25 h, acetone for 0.25 h, and then nitrogen blowing at 180 °C for 3 h.
- Preparation of column bed: Dissolve polyethylene glycol and urea in 0.01 mol/L acetic acid solution, stir until completely dissolved, place in an ice bath at 0 °C, and add tetramethoxysilane and chloropropyltrimethoxysilane dropwise silane, vigorously stirred for 4 h to obtain a transparent and uniform sol mixture; the sol mixture was ultrasonically oscillated for 5 min and then injected into the pretreated capillary, both ends of the capillary were sealed, reacted in a water bath at 55 °C for 12 h, and then distilled water respectively. Rinse with methanol to obtain chloropropyl-silica hybrid capillary monolithic column.
- Column bed modification: After ultrasonically treating the methanol aqueous solution containing o-phenanthroline and sodium iodide for 5 min, inject it into the prepared capillary, bath in 80 °C water for 12 h, and then rinse with double distilled water and methanol respectively to obtain Modified organo-silica hybrid capillary monolithic column.
The significant advantages of the present invention are:
- The present invention uses o-phenanthroline to modify the organic-silica gel hybrid capillary monolithic column, because the positive charge of o-phenanthroline can provide ion exchange sites, and at the same time, it has a pyridine ring with a large π-conjugated system and has a symmetrical structure, The monolithic column prepared with it has various forces such as π-π interaction, hydrogen bonding and electrostatic interaction, which can improve the separation effect.
- The present invention utilizes the organic-silica gel hybrid capillary monolithic column modified by o-phenanthroline, which not only eliminates the complicated and tedious operations such as traditional packed column packing, and the generation of air bubbles caused by sintered plugs, but also overcomes the problem of opening the column. The disadvantages of low capacity and relatively small size have the advantages of stable structure and good reproducibility.
Reference
- 1,10-Phenanthroline – PubChem
- CN201410517030.X Organo-silica hybrid capillary monolithic column modified by o-phenanthroline
- Evaluation of uncertainty in the determination of iron content in industrial sodium hydroxide by 1,10-phenanthroline Spectrophotometry.
o-Phenanthroline Supplier and Manufacturer
As a o-phenanthroline supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best o-phenanthroline raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
If you have a demand for o-phenanthroline and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.
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We will make samples before mass production, and after the sample is approved, we’ll begin mass production. Doing 100% inspection during production, then doing random inspection before packing.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantities, such as 100g on the condition that the sample charge is 100% paid.
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Quality Control of o-Phenanthroline

