N,N-Dimethylformamide CAS 68-12-2 DMF

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  • Appearance: Colorless liquid
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: N,N-Dimethylformamide Supplement

Basic Info of N,N-Dimethylformamide

What is N,N-Dimethylformamide?

N,N-Dimethylformamide (abbreviated as DMF) is a colorless, transparent liquid with strong polarity and low toxicity, making it a good organic solvent. With the rise of biopharmaceuticals, N,N-dimethylformamide (DMF) has been widely used as a solvent in the preparation of APIs and pharmaceutical intermediates.

As an important chemical raw material and a “universal organic solvent” with strong dissolving power, DMF is mainly used as a washing and curing agent in the synthesis industry such as polyvinyl chloride and polyacrylonitrile, dry spinning of acrylic fibers, and pharmaceutical synthesis intermediates in the pharmaceutical industry. , pesticides in the pesticide industry, dye solvents in the dye industry, quenching of tin-plated parts and cleaning of circuit boards in the electronics industry, etc. Other industries include as a carrier for hazardous gases, as a stationary phase in gas-liquid chromatography, as a solvent for the crystallization of pharmaceuticals, as a binder, and more.

DMF can also form complexes with many substances such as hydrochloric acid, sulfur trioxide, boron trifluoride, etc., which also has very important industrial significance. At present, the main application of DMF in China is the dry spinning of wet synthetic leather and acrylic fiber. Due to the increase in the content of toxic chemical reagents and pesticide standards, the application of DMF in the pesticide industry has gradually decreased. DMF has good thermal and chemical stability, and will not decompose even when heated to the boiling point in the absence of acids, bases and certain halogenated hydrocarbons. At 350°C or higher, DMF undergoes a decomposition reaction to generate carbon monoxide and dimethylamine. When boiling in an aqueous solution, DMF undergoes hydrolysis to generate formic acid and dimethylamine.

N,N-Dimethylformamide Uses

  1. N,N-Dimethylformamide is an exceptional natural solvent, made use of as a solvent for polyurethane, polyacrylonitrile, and polyvinyl chloride, and likewise made use of as an extractant, as a raw material for medications and also chemicals.
  2. N,N-Dimethylformamide is utilized for plastic movie making; it can also be made use of as a paint stripper for getting rid of paint.
  3. In the petrochemical sector, n,n-dimethylformamide can be utilized as a gas absorptive to separate and fine-tune gases.
  4. In natural reactions, n,n-dimethylformamide is not just widely used as a solvent for the response, but likewise an essential intermediate in natural synthesis.
  5. In the chemical industry, n,n-dimethylformamide can be utilized to generate ciprofloxacin.
  6. In the pharmaceutical market, n,n-dimethylformamide can be utilized to manufacture iodine, doxycycline, cortisone, vitamin B6, iodine, quercetin, pyrantel, N-formyl sarcomin, antitumor acid, methoxyfenmus, Bian Nitrogen mustard, cyclohexyl nitrosourea, furofluorouracil, hemostatic acid, bepartame, megestrol, bilevita, chlorpheniramine, and so on.
  7. DMF has a catalytic effect in the reactions of hydrogenation, dehydrogenation, dehydration and also dehydrohalogenation, to make sure that the response temperature is reduced as well as the product pureness is enhanced. Uses Non-aqueous titration solvent. Solvent for plastic and also acetylene. Photometric determination. Gas chromatographic fixed fluid (optimum temperature 50 ℃, solvent is methanol), can separate and also assess C2-C5 hydrocarbons, as well as can divide regular, isobutene as well as cis, trans-2-butene.

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The Preparation Method of N,N-Dimethylformamide

Reference

  1. N,N-Dimethylformamide – ChemicalBook
  2. N,N-Dimethylformamide – PubChem

Quality Control of N,N-Dimethylformamide

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