
N,N-Diisopropylethylamine CAS 7087-68-5



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- Appearance: Colorless liquid
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
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N,N-Diisopropylethylamine: The Complete Guide
- Item 1: Basic Info of N,N-Diisopropylethylamine
- Item 2: What is N,N-Diisopropylethylamine?
- Item 3: N,N-Diisopropylethylamine Uses
- Item 4: The Manager has Something to Say
- Item 5: Application of N,N-Diisopropylethylamine
- Item 6: Preparation of N,N-Diisopropylethylamine
- Item 7: Quality Control of N,N-Diisopropylethylamine
- Item 8: Hot Sale Products
- Item 9: Get N,N-Diisopropylethylamine Quotation
N,N-Diisopropylethylamine for Sale
Basic Info of N,N-Diisopropylethylamine
Chemical Name: | N,N-Diisopropylethylamine |
Other Name: | EthyldiisopropylaMine; DIPEA |
CAS: | 7087-68-5 |
EINECS: | 230-392-0 |
Type: | Organic intermediates; Pharmaceutical intermediates; Pharmaceutical raw materials |
Molecular Formula: | C8H19N |
Molecular Weight: | 129.24 |
Melting point | <-50 °C (lit.) |
Boiling point | 127 °C (lit.) |
density | 0.742 g/mL at 25 °C (lit.) |
vapor pressure | 31 mmHg ( 37.7 °C) |
refractive index | n20/D 1.457 |
Fp | 6 °C |
storage temp. | Store below +30°C. |
solubility | miscible |
pka | 10.98±0.28(Predicted) |
form | Liquid |
Specific Gravity | 0.755 (20/4℃) |
color | APHA: <20 |
PH | 12.3 (H2O, 20℃)(as an emulsion) |
explosive limit | 0.7-6.3%(V) |
Water Solubility | miscible |
Brand Name: | Zhishang Chemical |
Provide: | N,N-Diisopropylethylamine MSDS; N,N-Diisopropylethylamine COA |
What is N,N-Diisopropylethylamine?
N,N-Diisopropyl ethylamine, additionally referred to as hunig base, abbreviated as dipea or diea, is a sterically impeded amine as well as organic substance. This colorless fluid is named Hung’s base after the German drug store Siegfried hunig. It deserves keeping in mind that this compound is commercially readily available.
In organic chemistry, the substance is made use of as a base. Because the nitrogen center is divided by an ethyl team as well as 2 isopropyl groups, N,N-Diisopropyl ethylamine can bind to protons. For that reason, the compound is a base comparable to 2,2,6,6-tetramethylpiperidine, however the nucleophile is poor. This blending building makes it offered as a natural reagent.
Commonly, dipea was prepared by alkylation of diisopropylamine with diethyl sulfate. If needed, dipea can after that be cleansed by purification from potassium hydroxide.
Diisopropylethylamine (DIPEA) is an anemic as well as clear fluid, insoluble in water and conveniently soluble in acetone as well as various other natural solvents. DIPEA is a crucial chemical as well as pharmaceutical intermediate, which can be utilized to manufacture anesthetics and herbicides, as well as can also be made use of as a sterically impeded amine to take part in different catalytic responses. Diisopropylethylamine is likewise a vital organic synthesis intermediate, primarily made use of in the synthesis of pharmaceutical and pesticide intermediates, and also can also be used as a solvent, condensing representative, stimulant, and so on.
N,N-Diisopropylethylamine Uses
- N,N-Diisopropylethylamine (DIPEA) is an anemic as well as transparent fluid, insoluble in water, but quickly soluble in acetone and other natural solvents. DIPEA is an essential chemical and also pharmaceutical intermediate, which can be made use of to synthesize anesthetics as well as herbicides, as well as can also be utilized as a sterically impeded amine to take part in various catalytic reactions.
- Zero2 items are strictly degassed with high-purity inert gas to offer solvents and remedies with very low recurring oxygen material (if specified, anhydrous remedies).
- N,N-Diisopropyl ethylamine is made use of as a base in organic responses. It is utilized to prepare (-) gambierol, a marine polycyclic ether contaminant. It is additionally made use of to synthesize an effective prevention of human brain memapsin, which is a key effector in the progression of Alzheimer’s illness.
- When incorporated with trifluoromethanesulfonate borate, N,N-Diisopropyl ethylamine is commonly used in the enolation synthesis of ketones and in the directional cross adol response. When reacting with di-n-butyl boron trifluoromethane sulfonate as well as dipea in ether, 4-methyl-2-pentanone kinds an undivided enol baron.
- N,N-Diisopropyl ethylamine is used as a base in palladium (0) – militarized alkoxycarbonylation of allyl acetate and also phosphate. When treated with triphenylphosphine in the presence of dipea in ethanol under the pressure of carbon monoxide gas, diethyl 2-hexenylphosphate produced a mixture of CIS and also trans heptanoic acid ethyl esters in the ratio of 84:16. Dipea is used as a neutralizer for the produced phosphoric acid. It deserves noting that alkyl esters can not be created without dipea.
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Application of N,N-Diisopropylethylamine
CN201610876969.4 provides a preparation method of diisopropylethylamine trihydrofluoride, belonging to the technical field of organic synthesis.
As a fluorination reagent, diisopropylethylamine trihydrofluoride has incomparable advantages over hydrogen fluoride. Diisopropylethylamine trihydrofluoride is a nearly neutral substance and is non-corrosive to borosilicate glass containers; It can be used in the substitution reaction of carbohydrate derivatives and aromatic derivatives, as well as in the addition reaction and desiliconization of olefins. The preparation method provided by the present invention comprises the following steps: under the condition of -70~20℃, adding the organic solution of diisopropylethylamine dropwise to anhydrous hydrogen fluoride to react and let stand to obtain diisopropylethylamine triacetate Hydrofluoride.
The yield of the diisopropylethylamine trihydrofluoride obtained by the preparation method of the invention is as high as 96.45-99.37%.
CN201811149739.3 discloses a preparation method of carfilzomib. Carfilzomib is a proteasome inhibitor suitable for the treatment of patients with multiple myeloma, which is a malignant tumor originating from the B cell line It is characterized by the clonal proliferation of malignant plasma cells in the bone marrow microenvironment, causing fractures and bone marrow failure. It is the second most common hematological tumor in the world and cannot be cured by traditional chemotherapy. Bortezomib is the first Proteasome inhibitors are first-line drugs for multiple myeloma.
Including the following steps, prepare cyclohexane 30-50 mg, compound 100-200 mg, fluoroform 20-30 mg, organic base 50-100 mg, condensing agent 10-20 mg, N,N-diisopropylethylamine 80-150 mg, Dioxymethane 200-250 mg, Ethyl Toluene 50-80 mg, Isopropyl Acetate 20-60 mg, L-Phenylalanine 40-120 mg, Butyl Acetate 60-130 mg and n-heptane 10-20 mg, put L-phenylalanine 40-120 mg into the reaction dish, put N,N-diisopropylethylamine 80-150 mg and L-phenylalanine 40- 120 mg of the coupling reaction yielded mixture 1 and left to stand for 6 minutes.
The preparation method of carfilzomib has the advantages that the obtained carfilzomib has high purity and contains less impurities, so that the obtained carfilzomib finished product has higher value, and liquid nitrogen auxiliary control is completely unnecessary in the whole preparation process. It is warm, greatly reduces the cost of preparing carfilzomib, and is convenient for users to use.
Preparation of N,N-Diisopropylethylamine
A kind of synthetic method of DIPEA, carry out the following steps successively:
Add 101.1g (1.0mol) diisopropylamine, 332.0g (2.0mol) tetraethylammonium chloride, 101.1g ethanol, 60g (1.5mol) sodium hydroxide to the three-necked flask of 1000ml, heat to reflux, and keep The reflux temperature (80°C) was completed after 7 hours of reaction, cooled to room temperature, and the reaction mixture was removed from the solvent on a rotary evaporator, washed with 200 mL*3 of deionized water, and the oil phase washed three times was combined and collected at normal pressure. After rectification, 124.1 g of fractions at 125-127° C. were collected, which was the product DIPEA, the yield was 96.2%, and the purity detected by gas chromatography was 99.5%.
Remarks: The reactant is a solid-liquid mixture after removing low boilers and cooling to room temperature, and becomes a water-oil two-phase after washing.
A preparation method of N,N-diisopropylethylamine, comprises the following steps:
S1. Obtain raw materials and catalysts. The raw materials are ethanol and diisopropylamine, and the catalyst is Mo-Ni-Cu/Al2O3; the composition of the Mo-Ni-Cu/Al2O3 catalyst is: Mo is 8%, Ni is 25%, and Cu is 5% %, the rest is Al2O3
The catalyst preparation steps are:
A1, Al(OH) is prepared into a sodium metaaluminate solution with 40% NaOH, neutralized and precipitated with nitric acid, after aging, filtration, and washing, rolling, drying, and roasting are carried out to obtain a spherical Al2O3 carrier with a diameter of 3mm;
A2. The nitrates of Mo, Ni and Cu are made into a mixed solution in proportion, and the Al2O3 carrier is impregnated;
A3. After drying, put it into a muffle furnace for roasting; the temperature of the muffle furnace is 490℃, and the roasting time is 6h;
After A4 and A3 are calcined, they are cooled. After cooling, they are impregnated with a nitrate mixed solution of Mo, Ni and Cu. After calcination under the same conditions, the content of Mo-Ni- Cu/Al2O3 catalyst;
A5. After loading the catalyst into the reactor, reduce the catalyst with pure hydrogen at a pressure of 0.05MPa, a temperature of 460°C, and a space velocity of 1000h-1 for 24 hours to obtain a finished catalyst;
S2, mix ethanol and diisopropylamine into a mixed solution with a molar ratio of 1.2:1, and use a metering pump to push the mixed solution into the vaporizer of the reaction system, the pressure in the vaporizer is 0.8Mpa, the reaction temperature is 180 ℃, 1000ml catalyst Feed at a rate of 30ml/h;
S3, take the hydrogen in the system with the compressor to vaporize the mixed liquid of heated ethanol and diisopropylamine in the vaporizer, enter the fixed-bed reactor to react, and the obtained material enters the separator after cooling by the condenser;
S4, the liquid phase enters a rectifying tower for rectification and purification, and the obtained ethanol and diisopropylamine are used as raw materials to continue to be mixed into a mixed solution and enter the reaction system to obtain N,N-diisopropylethylamine, diethylamine, isopropanol and triethylamine;
The N,N-diisopropylethylamine, diethylamine, isopropanol and triethylamine obtained in S5 and S4 are respectively purified by rectification;
The reaction water produced by the rectification in S6 and S5 is biochemically treated to discharge standard discharge; the gas phase continues to be circulated in the system with the compressor.
A kind of synthetic method of N,N-diisopropylethylamine, take diisopropylamine and paraldehyde as starting raw material, carry out the following steps successively:
200mL of methanol was added to the 500mL reactor, followed by adding 34.5g of paraacetaldehyde (0.261mol) and 2g of concentrated hydrochloric acid (mass concentration 30%), and under normal pressure 25 ℃, the reaction was stirred for 30 minutes. Then 72 g of diisopropylamine (100 ml, 0.713 mol) and 47 g of sodium cyanoborohydride (0.748 mol) were added, and the reaction was maintained and stirred for 20 minutes.
After the reaction, the reaction solution was decompressed (0.1MPa) to remove methanol, and then 40% (mass concentration) NaOH solution was added to pH to 13. Separate the liquid and take the upper oil phase. Through atmospheric pressure batch rectification, the fraction of 126.8~128 ℃ was collected to obtain N,N-diisopropylethylamine 88.9g, and the yield was 96.5%.
A kind of production method of diisopropylethylamine, carry out the following steps successively:
1) In a tubular reactor with an inner diameter of 8mm and a length-to-diameter ratio of 30:1, use a metering pump to inject DIPA and Et2SO4 according to the ratio, and the raw material ratio n(DIPA):n(Et2SO4)=1.25:1.0 , the pressure is 0.6Mpa, the liquid space velocity of the reaction material is 0.2h-1 (under this liquid space velocity, the reactant stays in the tubular reaction device for 5 hours), and the reaction temperature is 125°C.
2) The material after the reaction is passed through the condenser at the outlet of the tubular reactor, and the amount of cooling water in the condenser is controlled, and the temperature of the material is controlled at 35°C.
3) The condensed material enters the stratifier, and the middle of the stratifier is provided with two feed ports, one feed port is the mixture of the condensed material and the strong alkali aqueous solution with a mass concentration of 20%, and the strong alkali aqueous solution is a continuous feed , its feed flow is automatically adjusted by interlocking with the online PH meter in the stratifier, so that the mixture always maintains the pH value of 13±0.5; the other feed port is petroleum ether, and the feed flow of petroleum ether is the material flow after condensation. 50%, the upper layer obtained after layering is an organic layer, the lower layer is an inorganic layer, and the inorganic layer is the water generated by the reaction and the water contained in sodium hydroxide;
4), the organic layer (organic layer material) of step 3) gained is the 1# rectifying tower that pressure is 0.6Mpa by pumping, the middle feed, the control rectifying tower reflux ratio is 3:1, in the rectifying tower The temperature is 52°C, and the temperature difference between the two temperature measuring points at the top of the tower is 12°C;
5), 1# rectifying tower tower bottom material enters the 2# rectifying tower with a pressure of 0.1Mpa to purify through the differential pressure, and feeds in the middle, and controls the reflux ratio of the rectifying tower to be 3:1, and the temperature in the rectifying tower is 127 ℃ , the temperature difference between the two temperature measuring points at the top of the tower is ≤3 °C for extraction; the product with a boiling range of 126.5 to 127.0 °C is diisopropylethylamine, and the tower kettle material is petroleum ether, which is fed through a pump and fresh petroleum ether. The tube is returned to the stratifier for recycling. The product was chromatographically analyzed w(DIPEA) was 99.86%, and the product yield was 96.55%.
Reference
- Diisopropylethylamine – PubChem
- [Chinese invention] CN202111443969.2 A kind of preparation method of N,N-diisopropylethylamine
- [Chinese invention] CN201810778240.2 A kind of preparation method of diisopropylethylamine trihydrofluoride
N,N-Diisopropylethylamine Supplier and Manufacturer
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Quality Control of N,N-Diisopropylethylamine

