N,N-Diisopropylethylamine CAS 7087-68-5

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  • Appearance: Colorless liquid
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: N,N-Diisopropylethylamine Supplier & Manufacturer

Basic Info of N,N-Diisopropylethylamine

What is N,N-Diisopropylethylamine?

N,N-Diisopropyl ethylamine, additionally referred to as hunig base, abbreviated as dipea or diea, is a sterically impeded amine as well as organic substance. This colorless fluid is named Hung’s base after the German drug store Siegfried hunig. It deserves keeping in mind that this compound is commercially readily available.

In organic chemistry, the substance is made use of as a base. Because the nitrogen center is divided by an ethyl team as well as 2 isopropyl groups, N,N-Diisopropyl ethylamine can bind to protons. For that reason, the compound is a base comparable to 2,2,6,6-tetramethylpiperidine, however the nucleophile is poor. This blending building makes it offered as a natural reagent.

Commonly, dipea was prepared by alkylation of diisopropylamine with diethyl sulfate. If needed, dipea can after that be cleansed by purification from potassium hydroxide.

Diisopropylethylamine (DIPEA) is an anemic as well as clear fluid, insoluble in water and conveniently soluble in acetone as well as various other natural solvents. DIPEA is a crucial chemical as well as pharmaceutical intermediate, which can be utilized to manufacture anesthetics and herbicides, as well as can also be made use of as a sterically impeded amine to take part in different catalytic responses. Diisopropylethylamine is likewise a vital organic synthesis intermediate, primarily made use of in the synthesis of pharmaceutical and pesticide intermediates, and also can also be used as a solvent, condensing representative, stimulant, and so on.

N,N-Diisopropylethylamine Uses

  1. N,N-Diisopropylethylamine (DIPEA) is an anemic as well as transparent fluid, insoluble in water, but quickly soluble in acetone and other natural solvents. DIPEA is an essential chemical and also pharmaceutical intermediate, which can be made use of to synthesize anesthetics as well as herbicides, as well as can also be utilized as a sterically impeded amine to take part in various catalytic reactions.
  2. Zero2 items are strictly degassed with high-purity inert gas to offer solvents and remedies with very low recurring oxygen material (if specified, anhydrous remedies).
  3. N,N-Diisopropyl ethylamine is made use of as a base in organic responses. It is utilized to prepare (-) gambierol, a marine polycyclic ether contaminant. It is additionally made use of to synthesize an effective prevention of human brain memapsin, which is a key effector in the progression of Alzheimer’s illness.
  4. When incorporated with trifluoromethanesulfonate borate, N,N-Diisopropyl ethylamine is commonly used in the enolation synthesis of ketones and in the directional cross adol response. When reacting with di-n-butyl boron trifluoromethane sulfonate as well as dipea in ether, 4-methyl-2-pentanone kinds an undivided enol baron.
  5. N,N-Diisopropyl ethylamine is used as a base in palladium (0) – militarized alkoxycarbonylation of allyl acetate and also phosphate. When treated with triphenylphosphine in the presence of dipea in ethanol under the pressure of carbon monoxide gas, diethyl 2-hexenylphosphate produced a mixture of CIS and also trans heptanoic acid ethyl esters in the ratio of 84:16. Dipea is used as a neutralizer for the produced phosphoric acid. It deserves noting that alkyl esters can not be created without dipea.

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Application of N,N-Diisopropylethylamine

Preparation of N,N-Diisopropylethylamine


  1. Diisopropylethylamine – PubChem
  2. [Chinese invention] CN202111443969.2 A kind of preparation method of N,N-diisopropylethylamine
  3. [Chinese invention] CN201810778240.2 A kind of preparation method of diisopropylethylamine trihydrofluoride

N,N-Diisopropylethylamine Supplier and Manufacturer

As a n,n-diisopropylethylamine supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best n,n-diisopropylethylamine raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for n,n-diisopropylethylamine and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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