Nicotinamide Riboside Chloride CAS 23111-00-4 NR-CL

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  • Appearance: White powder
  • Assay: 99. 0%min
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Basic Info of Nicotinamide Riboside Chloride

What is Nicotinamide Riboside Chloride?

Nicotinamide ribose was first discovered by scientists in 1944. Scientists found that in Haemophilus influenzae (type H influenza virus), nicotinamide ribose is the growth factor of bacteria. These factors that can promote bacteria were called V factors at that time. The purified blood of type V factor exists in three forms: NAD+, NMN and NR. Nicotinamide ribose is the fastest cause of bacterial growth. At the same time, scientists found that the type H influenza virus could not grow on nicotinic acid, nicotinamide, tryptophan or aspartic acid. These substances were previously considered to be NAD+driving substances of nicotinamide adenine dinucleotide. In 2000, yeast Sirt2 was confirmed to be protein lysine deacetylation dependent on nicotinamide adenine dinucleotide (NAD+). Because the scientific community has found that SIR2 gene exists from yeast to human before, and it is known from experiments that their life span has been extended after the addition of additional SIR2 gene to yeast, nematode, drosophila, etc. The dependence of SIR2 on nicotinamide adenine dinucleotide (NAD+) has aroused more scientific attention. Scientists began to study how to increase the level of nicotinamide adenine dinucleotide (NAD+), so as to achieve the effect of regulating life span and delaying or even reversing aging.

Researchers from Dartmouth College in the United States cloned nicotinamide riboside kinase from yeast and human body, and both in vitro and in vivo proved that the kinase can convert nicotinamide ribose NR into NMN. They also showed that NR is a natural product and a vitamin that has been hidden in milk.

In the research report of Professor David Sinclair of Harvard Medical School in 2013 (page archive backup, stored in the Internet Archives), researchers injected 2-year-old mice with substances that can produce nicotinamide adenine dinucleotide NAD+, and then observed indicators of resistance to insulin, inflammation and muscle loss. The researchers found that in only one week, the tissues of two year old mice returned to those of six month old mice. It is like a 60 year old man who has turned back to 20 years old within these indicators. Studies have shown that enhancing nicotinamide adenine dinucleotide can promote healthy mitochondrial function. The weakening of mitochondrial function is an important factor leading to human aging.

Nicotinamide Riboside Chloride Uses

Since most studies on nicotinamide riboside and NAD+are from animal studies, it is impossible to draw clear conclusions about their effectiveness in humans. In other words, we can only say some potential health benefits of nicotinamide ribosomes:

NAD+ is a coenzyme or accessory molecule associated with several organic responses.

Although this is vital for ideal wellness, study reveals that NAD+ degrees remain to decline with age. Lower NAD+ levels have been linked to aging as well as various hazardous conditions.

One way to increase NAD+ levels is to eat NAD+ precursors (the foundation of NAD+), such as nicotinamide riboside.

Animal research studies have actually shown that nicotinamide riboside can enhance the level of NAD+ in the blood by as much as 2.7 times. Likewise, it is simpler for your body to use than other NAD+ forerunners.

Nicotinamide Ribose helps enhance NAD+ degrees in the body.

In reaction, NAD+ turns on particular enzymes that advertise healthy aging.

One is sirtuins, which can enhance the life expectancy and overall health of animals. Research studies have shown that sirtuins can fix broken DNA, boost tension resistance, decrease inflammation and provide various other benefits that advertise healthy and balanced aging. Sirtuins are also responsible for calorie-restricted long life.

The other is poly( ADP-ribose) polymerase (PARP), which fixings harmed DNA. Research studies have linked greater PARP task to much less DNA damage as well as longer lifespan.

NAD+ plays a crucial function in helping your mind cells age.

Within mind cells, NAD+ helps manage the production of PGC-1-alpha, a protein that appears to aid safeguard cells from oxidative stress as well as damaged mitochondrial feature.

Researchers believe that both oxidative tension as well as impaired mitochondrial feature are associated with age-related brain conditions such as Alzheimer’s and also Parkinson’s diseases.

In mice with Alzheimer’s illness, nicotinamide riboside raised the brain’s NAD+ degrees and PGC-1-alpha production by 70% and 50%, respectively. By the end of the research study, the computer mice carried out dramatically better on memory-based tasks.

In one test-tube research study, nicotinamide riboside increased levels of NAD+ in stem cells from people with Parkinson’s condition as well as substantially enhanced mitochondrial feature.

However, it is vague just how much enhancing NAD+ levels in people with age-related brain disorders can assist. Much more human study is required.

Aging is a major danger element for heart problem, which is the leading cause of death in the world. It can create capillary like your aorta to enlarge, set, as well as soften.

Such adjustments can elevate blood pressure degrees as well as impact your heart.

In animals, enhancing NAD+ helps reverse age-related arterial adjustments.

In people, nicotinamide riboside enhances NAD+ levels, helps in reducing aortic stiffness and minimizes systolic high blood pressure in grownups in jeopardy for high blood pressure. Nevertheless, even more human research is still required.

Additionally, nicotinamide riboside may provide a few other benefits:.

May aid with weight reduction: Nicotinamide riboside helps speed up metabolism in mice. Nonetheless, it is uncertain whether it would certainly have the exact same impact in people, as well as how strong the impact might be.

Might Reduce Cancer Threat: High NAD+ levels assist shield versus DNA damages as well as oxidative anxiety, which have actually been linked to cancer growth.

Might Help Treat Jet Lag: NAD+ helps regulate the body’s internal clock, so taking nicotine might assist treat jet lag or other circadian rhythm problems by resetting the body’s body clock.

May promote healthy muscular tissue aging: Raising NAD+ levels assists enhance muscle function, toughness, and endurance in aged mice.

Recap: Nicotinamide riboside increases NAD+ degrees, which have been connected to prospective health advantages such as aging, mind health, heart problem danger, and also much more.

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Application of Nicotinamide Riboside Chloride

Doxorubicin, an anthracycline antibiotic, is one of the most effective and widely used chemotherapeutic drugs in the treatment of various types of solid tumors. Unfortunately, its cardiotoxicity in the treatment of cancer has limited the drug’s usefulness for decades. clinical use. The mechanism of doxorubicin-induced cardiotoxicity is very complex. Studies have shown that oxidative stress, cardiomyocyte death (apoptosis and programmed death), and autophagy dysfunction may be the main mechanisms of doxorubicin-induced cardiotoxic injury. At present, the clinical prevention and treatment of doxorubicin-induced cardiotoxicity is extremely limited, so further research on it is extremely necessary. Nicotinamide riboside is widely present in daily food as a precursor of NAD+. NAD+ plays an important role in the body. It is particularly important to point out that NAD+ is required for Sirt1 activation and can regulate intracellular redox signals, so it can resist oxidative stress in cardiomyocytes and protect myocardial immunity. damaged.

Therefore, nicotinamide riboside may protect the heart from damage caused by doxorubicin. Nicotinamide riboside attenuates doxorubicin cardiotoxic injury by improving autophagic flux. Doxorubicin can cause cardiotoxicity and reduce cardiac function; nicotinamide riboside can reduce doxorubicin-induced cardiotoxicity and improve cardiac function, and its protective effect is in a dose-response relationship; doxorubicin can block autophagic flow, thereby Induces the production of reactive oxygen species, causing myocardial damage and impaired cardiac function; nicotinamide riboside can improve autophagic flow in doxorubicin cardiotoxicity, while blocking autophagic flow can eliminate the effect of nicotinamide riboside on doxorubicin-induced myocardial Injury protection; In the myocardial injury of doxorubicin, inhibition of Sirt1 activity can abolish the protective effect of nicotinamide riboside on autophagic flux and myocardial injury. Conclusions: Nicotinamide riboside protects cardiomyocytes from doxorubicin-induced myocardial reactive oxygen species production and myocardial injury, which are related to the activation of Sirt1 signaling and the maintenance of autophagic flow. Therefore, nicotinamide riboside may be a drug for the prevention and treatment of doxorubicin cardiotoxic injury.

Prospective Risks as well as Negative Effects

Nicotinamide riboside is risk-free and also has few side effects.

In human research studies, taking 1,000 to 2,000 mg daily had no damaging effects (28Trusted Resource, 29Trusted Source ). Nevertheless, most human studies are short in duration as well as have couple of individuals. Extra robust human studies are needed to get an extra accurate photo of its safety and security.

Some individuals report mild to moderate adverse effects, such as nausea or vomiting, exhaustion, migraine, diarrhea, indigestion, as well as indigestion.

In pets, day-to-day dosages of 300 mg/kg body weight (136 mg/lb) for 90 days revealed no negative results.

And also, unlike vitamin B3 (niacin) supplements, nicotinamide riboside ought to not create face flushing.

Summary: Nicotinamide riboside seems secure with couple of adverse effects. Nevertheless, its long-lasting effects on human beings continue to be reasonably unknown.

Reference

  1. Nicotinamide riboside chloride – PubChem
  2. Supplementation with nicotinamide riboside may improve arterial health and blood pressure

Nicotinamide Riboside Chloride Suppliers and Manufacturers

As a nicotinamide riboside chloride supplier and manufacturer with strict standard product quality system certificate, Zhishang Chemical has long been providing the best nicotinamide riboside chloride raw materials to customers all over the world.

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