Nano Gun Technology Launches Precision Killing Tumor Tissue
At the first global nano-gun technology forum held recently, the reporter learned that the world`s first clinical trial using nano-gun technology to treat advanced liver cancer was successfully performed in a top-level hospital in Zhejiang province. According to Yang Guanghua, chief scientist of the project and a special expert of the National "Thousand People Project", "Nano Gun" technology is the abbreviation of the new nanoparticle-targeted radionuclide (ImDendrim) for the treatment of solid tumors. Nano guns do not belong to drugs and are essentially a therapeutic technique. By locally injecting radionuclide nanoparticles into the interior of a tumor, nanoparticles loaded with nitroimidazole probes diffuse into the entire tumor tissue (especially larger tumors). The internal hypoxic region) makes the 188 release of beta-rays in the probe accurately kill the tumor cells. The new isotope nanoparticles they use are 188Re, a beta particle emitter with a half-life of 16.7 hours. The maximum penetration distance in tissues is 10 millimeters (average 5 millimeters). It can kill tumor cells at close range without damaging nearby The organization is safe and reliable. "Our breakthrough in technology is mainly to couple nitroimidazole with nuclide. Such a coupling will be specifically absorbed by tumor cells, but will not spread to normal tissues," said Yang Guanghua.
It is reported that the core of this "nano-gun" technology is the first to achieve the coupling of hypoxia-targeted hypoxic tumor cells with isotope 188 by massive absorption of tumor tissues by nitroimidazole. DNA makes the tumor cells unable to replicate and eventually become apoptotic. Second, the G5 dendrimer nanomaterial (20 nm) formed using the emerging nanotechnology allows the nuclide particles to diffuse within the tumor tissue without affecting the extraneous normal tissues.