In May 2020, scientists such as Kiss Tamas from the Department of Geriatrics, University of Oklahoma Health Science Center, revealed for us the specific mechanism of NMN improving angiogenesis and preventing vascular dementia: activation of Sirtuins → reduction of mitochondrial ROS → improvement Neurovascular coupling (NVC) response→Significantly protect the cerebral blood vessels.
This time, they found a new basis for NMN to protect blood vessels: NMN can reverse the level of microRNA (miRNA) in the aging blood vessels of mice, thereby rejuvenating the epigenetics and resisting atherosclerosis. Their research results were published in the Journal of Gerontology.
miRNA is also one of the biomarkers of aging, and it has the function of regulating the lifespan of model organisms.
As we age, miRNAs in blood vessels will become dysfunctional and play an important pathogenic role in cellular mechanisms that target key signal transduction pathways, inflammation, and protein homeostasis, thereby impairing the integrity of the vascular system’s structure and function.
Can NMN show its talents in this regard?
To this end, the researchers selected C57BL/6 mice at the age of 3 months (equivalent to adult) and 24 months (equivalent to old age) as experimental subjects. Some of them were injected with NMN500mg/kg daily intraperitoneally for two weeks. Subsequently, they measured the expression of miRNA in the aorta of adult mice, old mice given NMN, and old mice without NMN treatment: as expected, the expression level of miRNA differed greatly between young and aging vascular endothelium. Different miRNAs Up-regulation or down-regulation with age, and administration of NMN reversed the age-related changes in miRNA expression profiles.
The regulatory effects of NMN on miRNA may be multifaceted, including transcription and post-transcriptional regulatory mechanisms. Transcription regulation may involve changes in transcription factor activity, changes in genome accessibility (such as histone modifications), and changes in the methylation status of miRNA gene promoters; post-transcriptional regulation may include restoring miRNA processing pathways and improving miRNA stability.
NMN can significantly change the gene expression regulatory network by changing the miRNA profile, and make the epigenetic regeneration of the vasculature. Based on this, the researchers also tried to use the IRIDESCENT system to predict the biological effects of miRNA target genes, and the results showed that NMN may have the effect of promoting epigenetic regeneration.
NMN can significantly change the gene expression regulatory network by changing the miRNA profile, and make the epigenetic regeneration of the vasculature. Based on this, the researchers also tried to use the IRIDESCENT system to predict the biological effects of miRNA target genes, and the results showed that NMN may have the effect of promoting epigenetic regeneration.
Summary: This paper points out that NMN can reverse the expression profile of miRNA in aging blood vessels, and the latter has a direct causal relationship with the development of cardiovascular aging phenotypes and cardiovascular pathogenesis. It can be said to be an additional addition to “NMN protects blood vessels”. A real hammer. The miRNA may cause changes in epigenetics, which means that its anti-aging mechanism has more possibilities. Let us look forward to their future research results.
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