N-Iodosuccinimide CAS 516-12-1

3-Iodoimidazo[1,2-b]pyridazine is an important intermediate in organic synthesis, mainly used in pharmaceutical intermediates, organic synthesis, organic solvents, and can also be used in dye production, pesticide production and spices. The heterocyclic compound is newly synthesized, the product is novel and has great value.

CN201510630318.2 reports a synthesis method of 3-iodoimidazo[1,2-b]pyridazine. Using 3-aminopyridazine, chloroacetaldehyde aqueous solution, and N-iodosuccinimide as raw materials, the ratio of 3-aminopyridazine and chloroacetaldehyde is 1:0.8-3.5, 3-amino The ratio of pyridazine to N-iodosuccinimide is 1:0.65-2.1. In a suitable solvent, react at 40-150°C to generate 3-iodoimidazo[1,2-b]pyrid The crude product of 3-iodoimidazo[1,2-b]pyridazine can be obtained after purification. The raw materials of the present invention are relatively easy to obtain, and the price is reasonable. At the same time, no heavy metals and corrosive gases are used in the preparation reaction, and the reaction is mild. There is no special requirement on the reflection equipment, and ordinary corrosion-resistant equipment can be used for production. In addition, the reaction conditions of the present invention are moderate.

Tetrahydrofuran compounds are one of the very important intermediates in organic synthesis, and also one of the common structural units in natural products. At present, many compounds containing this skeleton have been proved to have many potential physiological activities, and have great development and utilization value in the field of biotechnology, medicine and pesticides.

CN200810162686.9 reports a synthetic method of optically active (S)-2-(1′(Z)alkenyl iodoalkyl)tetrahydrofuran, which uses optically active (R)-4,5-alkenol as the reaction Iodine cyclization of the substrate with the electrophile N-iodosuccinimide yields optically active (S)-2-(1′(Z)alkenyliodoalkyl)tetrahydrofuran (in large quantities) and (R )-2-(1′(E)alkenyl iodoalkyl)tetrahydrofuran (a small amount); Utilize Z/E isomer under the co-catalysis of bis(triphenylphosphine)palladium dichloride and cuprous iodide with The speed of the Sonogashira coupling reaction of propynyl alcohol is different, and the optically active (S)-2-(1′(Z) alkenyl iodoalkyl)tetrahydrofuran of the Z configuration is obtained; the operation is simple, the raw materials and reagents are easy to obtain, and the reaction It has high regio and stereoselectivity, can introduce multiple substituents at the same time, and the product is easy to separate and purify, and is suitable for synthesizing various substituted optically active tetrahydrofuran compounds.