N-Iodosuccinimide CAS 516-12-1

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  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: N-Iodosuccinimide Supplier & Manufacturer

Basic Info

What is N-Iodosuccinimide?

N-iodosuccinimide, commonly abbreviated as NIS, is a white needle-like crystal that disintegrates in water, soluble in water, methanol, as well as dioxane, as well as insoluble in carbon tetrachloride.

NIS is an important electrophilic iodine reagent in organic chemistry. It can react with alkenyl aluminum intermediates to prepare alkenyl iodide compounds. It can also be used as an oxidizing reagent to oxidize and ring-close dipeptides to prepare β- Lactam.

NIS is a good iodide reagent, which can smoothly convert vinylsilane and vinylstannane into the corresponding vinyl iodides. In addition, under mild conditions, the reaction of alkene boronic acids with NIS can be converted into alkene iodides with unchanged geometry.

NIS is easy to decompose and should be stored under nitrogen protection at low temperature and away from light and moisture. Care should be taken to take necessary measures during use to prevent inhalation of powder with pungent odor.

Production approach: N-iodosuccinimide can be acquired by reacting the liquid service of succinimide with silver oxide to acquire the silver salt of succinimide, and afterwards reacting with iodine. Uses: N-iodosuccinimide can be utilized as a reagent to iodide aldehydes as well as ketones.

N-Iodosuccinimide Uses

  1. Mainly used as pharmaceutical intermediates in biopharmaceuticals. Used in organic synthesis, sulfur oxidation titration reagent, mild iodination agent, glucosinolate catalyst, etc.
  2. N-Iodosuccinimide is used for the chemoselective hydrolysis of glucosinolates with TFA to generate 1-hydroxyglycosides; through an efficient 2-step process via 1,6-diynes to prepare highly substituted iodobenzenes; from alkenes and benzenesulfinic acid Synthesis of vinyl sulfone.
  3. N-iodosuccinimide is used to prepare vinyl sulfone from olefins and Phenylsulfinic acid. As a source of I+, it participates in Hunsdiecker reaction, transforming Cinnamic acid and Propiolic acid into corresponding α- Halogenated styrene and 1-halo-1-alkynes. It is also used to hydrolyze thioglycosides to 1-hydroxyglycosides together with Trifluoroacetic acid. It involves the preparation of iodobenzene from 1,6-diyne. In addition, it acts as an iodizer in chemical synthesis.

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Application of N-Iodosuccinimide


  1. N-Iodosuccinimide – WikiPedia
  2. [Chinese invention] CN201510630318.2 Synthetic method of 3-iodoimidazo[1,2-b]pyridazine

N-Iodosuccinimide Supplier and Manufacturer

As a n-iodosuccinimide supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best n-iodosuccinimide raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for n-iodosuccinimide and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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