SHANDONG ZHISHANG CHEMICAL CO.LTD.

Minoxidil CAS 38304-91-5

Factory Supply Minoxidil CAS 38304-91-5 with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Minoxidil Supplier & Manufacturer

Basic Info

What is Minoxidil?

Minoxidil is a peripheral vasodilator. It was first developed to treat high blood pressure and was called “Chalantidine and Minoxidil”. In 1971, clinical trials found that using it for more than 2 months would cause hirsutism as a side effect. This is undoubtedly great news for hypertensive patients suffering from hair loss. They were surprised to find that their lost hair had grown back! Thus, topical minoxidil tincture to treat hair loss was born.

In 1987, the U.S. Food and Drug Administration (FDA) approved 2% minoxidil for marketing in the United States for the treatment of male hair loss.

In recent years, with the continuous improvement of living standards, more and more people have begun to realize the importance of personal image. And the hair, which occupies the commanding heights in the overall image, cannot be ignored. As an important part of human body beauty, hair also shoulders the important task of showing a beautiful overall image of human beings.

However, in modern life, baldness and hair loss have become a common and frequently-occurring disease for humans today. It is a relatively sensitive and miserable thing. According to the American Society of Facial Plastic and Reconstructive Surgery, due to the fast-paced work and life, more than 2/3 of men and more than 1/5 of women worldwide are suffering from baldness and hair loss, which has become a problem that affects their normal life and work. One of the factors is that most people with baldness and hair loss look forward to using drugs to make up for their image deficiencies. Factors causing baldness or hair loss are divided into two types: congenital and acquired. Congenital alopecia or hair loss is mostly inherited as autosomal recessive or dominant. Acquired alopecia is often caused by diseases (such as inflammation, infection, endocrine disorders, etc.), neurological disorders, mental disorders, nutritional and metabolic disorders, injuries, scars, chemical factors and other factors. Minoxidil is a vasodilator that can be used to treat hair loss.

Minoxidil Uses

  1. Blood pressure-lowering drugs for refractory, essential or renal hypertension. Used to prevent oily hair loss and animal husbandry.
  2. The conversion of minoxidil to its active derivative minoxidil sulfate by follicular sulfotransferase activity is a critical step for the drug’s effectiveness. Minoxidil can cause the telomere phase to shorten, the anagen phase to prolong, and the hair follicle diameter and length to gradually increase. Some patients with hair loss will apply minoxidil liniment on the hair loss area in the hope of hair growth; some men will even apply it around the mouth and face in the hope of growing a suitable beard.
  3. Minoxidil is a peripheral vasodilator that, when used topically and long-term, can stimulate hair growth in patients with male pattern baldness and alopecia areata. The exact mechanism by which minoxidil tincture treats hair loss is unknown. Clinical studies have shown that minoxidil does not exhibit systemic effects due to absorption when used topically in normotensive and untreated hypertensive patients.
  4. Minoxidil is a peripheral vasodilator used to treat severe and refractory hypertension. It has a rapid onset and long-lasting effect. In long-term clinical application, it was found that patients who took the drug for more than one month could develop hirsutism of varying degrees, which led to extensive and in-depth research on its use in the treatment of baldness and hair loss. Its vasodilatory effect can improve the blood circulation and nutrient supply of the scalp and re-grow hair follicles. It is suitable for baldness and hair loss caused by various reasons. It is a safe and effective method to treat baldness and hair loss.

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This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

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If you want to buy minoxidil, pls contact us to get a free quote.

In addition to following the dosage on time, are there any other tips that can help bring out the effect of the medicine?

  • Shave your hair short or expose your scalp
    Some people shave their heads for the convenience of medication, which is beneficial from the perspective of medication. However, shaving your head often can easily rub off many hair follicles, so it is recommended to shave your hair short, or try to lift the hair to expose the scalp when taking medication. Spray the medicine on your scalp and massage it for better absorption.
  • Increase drug concentration
    The drug concentrations of minoxidil are 2%, 3%, 5%, 15%, etc. Clinically, 2% is generally recommended for young ladies and 5% for young brothers. This is a safe and effective concentration. Therefore, if the effect is not obvious, you can consult a doctor to see if the concentration of the drug can be increased. Do not increase the concentration randomly on your own.
  • Drug combination
    It is common clinically to combine minoxidil and finasteride. The combined use of both parties will have a much better effect than the use of minoxidil alone, because finasteride has a good anti-hair loss effect and is the same as minoxidil. The way to combine inside and outside.
  • Add auxiliary therapy
    Western medicine pays attention to primary therapy and auxiliary therapy. While taking medication, you can use a comb to comb your hair, massage, or the anti-hair loss essence of some skin care products to assist the therapy. These therapies cannot directly replace the medication, but when used in conjunction with the medication, the effect will be doubled.

Side Effects of Using Minoxidil

  1. “Crazy shedding” after stopping minoxidil
    In fact, the term “crazy shedding” is not accurate. It should be called the shedding period of minoxidil. The mechanism of action of minoxidil is to change the growth cycle of hair follicles. In our lifetime, hair follicles go through more than a dozen growth cycles, and a normal cycle lasts 5-6 years.
    The difference between patients with seborrheic alopecia and other types of hair loss is that once the hair falls out, it no longer grows because a large number of hair follicles enter the resting phase from the growth phase. If they continue to develop, the hair follicles will shrink, eventually leading to baldness.
    Minoxidil can transform the telogen hair follicles into the growth phase. During this process, some telogen hair follicles still have hair, and the ones that should fall off have not yet fallen off. After these telogen hair follicles are stimulated by the drug, the hair will Shedding early, this is the shedding period of minoxidil.
    Strictly speaking, this is not a side effect, it is just a normal reaction of some people after using minoxidil.
  2. Itching and increased dandruff
    Most people will feel this way when they first use minoxidil, but they can generally tolerate it and the symptoms will generally disappear if they continue to use it. If the symptoms worsen, you can reduce the dosage. If the symptoms worsen and you are still intolerable after reducing the dosage, you need to Deactivate.
  3. Impact on cardiovascular disease
    Mino itself opens potassium ion channels and makes local blood circulation faster. Therefore, it is normal to feel a faster heartbeat and excitement during the initial use of Mino. Like the above symptoms, it will generally disappear after using it a few times.
    Minox was originally an antihypertensive drug, but some experiments have shown that topical Minox has no effect on systemic blood pressure. However, patients with low blood pressure and heart disease should not use it.
  4. Minoxidil recovery
    This is probably one of the topics that many hair loss friends are most concerned about. Many hair loss patients who have taken medications have raised this question.
    First of all, let’s make it clear that seborrheic alopecia, androgenetic alopecia, and hereditary alopecia cannot be completely cured, and many patients require long-term maintenance with medications. Mino will achieve better results when used for more than 12 months. If you continue to use it, the effect will not be doubled, but it will be maintained. After stopping use, many people will feel that the hair loss returns.
    The recurrence of hair loss is not caused by minoxidil, but the hair loss itself continues. Neither minoxidil nor finasteride can completely cure hair loss. The effect of drugs is limited! It can only be alleviated, not cured.
    Some hair friends said that some hair loss patients said that minoxidil was ineffective because they used it for too short a time, and the drug has an incubation period for its effect. So what do you say to patients with hair loss who have been using minoxidil for a year but have no effect? Hair friends who have done the drug test of minoxidil know that if the person’s body lacks “sulfo aminotransferase”, the effect of minoxidil on hair growth will be minimal.
    In order for minoxidil to have a hair-growing effect, it must be combined with a substance called “sulfoaminotransferase”, which exists in the scalp and hair follicles. Minoxidil can bind to the sulfotransaminase (sulfotransaminase) in the scalp. sulfratrasferas), minoxidil sulfate is formed. Minoxidil sulfate is a key ingredient for hair growth, and its activity directly determines the effectiveness of minoxidil in the treatment of hair loss. effectiveness.

References

  1. Chen Shengli, Sun Jianfang. Pharmacological and clinical research on minoxidil in the treatment of hair loss[D]. , 2004.
  2. Sica DA (May 2004). “Minoxidil: an underused vasodilator for resistant or severe hypertension”Journal of Clinical Hypertension.
  3. Suchonwanit P, Thammarucha S, Leerunyakul K (2019). “Minoxidil and its use in hair disorders: a review”Drug Design, Development and Therapy

Minoxidil Supplier and Manufacturer

As a minoxidil supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best minoxidil raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for minoxidil and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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