Microcrystalline Cellulose CAS 9004-34-6 MCC

Factory Supply Microcrystalline Cellulose CAS 9004-34-6 MCC with Best Price

  • Appearance: White powder
  • Purity: 99. 0%min
  • Stock: In stock
  • Sample: Available
  • Zhishang Chemical: Microcrystalline Cellulose Supplier & Manufacturer

Basic Info

What is Microcrystalline Cellulose?

Microcrystalline cellulose (MCC) is a product of natural cellulose that is acid hydrolyzed to the ultimate degree of polymerization. Its color is white or nearly white, odorless and tasteless. The particle size is generally about 2 to 80 μm. It has low density and good modulus. It has the advantages of high efficiency, renewable, degradable and wide source, and can be used as a reinforcing agent for composite materials to improve the performance of the materials.

Microcrystalline cellulose generally has a lower density when freeze-dried, and a higher density when spray-dried. Moisture content is approximately 5%. Microcrystalline cellulose is dispersible but insoluble in water, insoluble in dilute acids, organic solvents and oils, and swells and partially dissolved in dilute alkali solutions. Disperse microcrystalline cellulose powder in water to obtain a white transparent gel or paste. Except for extremely thin ones, it remains stable for many years.

Microcrystalline cellulose, also known as MCC or cellulose gel, is widely used as excipients, binders and disintegrants in pharmaceutical tablets, suspending agents in liquid pharmaceutical preparations, and in food applications including beverages. Stabilizers and binders, stabilizers, binders and disintegrants and processing aids in cosmetics. MCC is used alone in food or as a fat substitute in collaborative processing modifications. MCC has good prospects for use in drugs and food, and its usage is increasing every year. It is an excellent pharmaceutical excipient and food additive. In pharmaceutical production, it is an excellent excipient for improving drug dissolution. In the food industry, it is a highly recommended food additive for improving food taste, reducing food calories, and preventing obesity.

Microcrystalline Cellulose Uses

Microcrystalline cellulose is approved within the European Union as a thickener, stabilizer, or emulsifier, with an E number of E460 (i) and an alkaline cellulose with an E number of E460.

MCC can be used as abrasives, absorbents, anti caking agents, water-based tackifiers, adhesives, extenders, lotion stabilizers, smoothing modifiers and texture agents in cosmetics, as well as in various hair and skin care products and cosmetics.

MCC is a valuable additive in industries such as medicine, food, and cosmetics. Measure the different properties of MCC to determine its suitability for such purposes, including particle size, density, compression index, angle of rest, powder porosity, hydration expansion ability, moisture absorption ability, moisture content, crystallinity index, microcrystalline size, and mechanical properties such as hardness and tensile strength.

Microcrystalline cellulose is a polymer of glucose that is edible but not digestible by the human body and can be used as a food additive. Vegetables, fruits, and other foods that people eat in their daily lives contain fiber. Its function is to regulate human physiological functions, promote intestinal peristalsis, and prevent constipation and other diseases; Ultrafine microcrystalline cellulose can form colloids by combining with water, and is used as an emulsifying thickener for food or cream. Microcrystalline cellulose is commonly used as a drug excipient in medicine, which endows drugs with functions such as carrier, sustained release, and protection.

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Properties of Microcrystalline Cellulose

  1. The biggest application feature of microcrystalline cellulose in solid preparations is its high degree of compressibility. Compared with other solid pharmaceutical excipients, this is due to the existence of hydrogen bonds between microcrystalline cellulose molecules. Association and therefore high compressibility, which can increase tablet hardness. Therefore, it is often used as a dry binder; at the same time, because when the compressed tablet encounters liquid, water quickly enters the inside of the tablet containing microcrystalline cellulose, and the hydrogen bonds are immediately broken, so it can also be used as a disintegrant. Therefore, it is widely used in tablet production.
  2. Microcrystalline cellulose has high water absorption. On the one hand, this feature has good slurry absorption ability during the wet granulation process, and there is enough space for the binder/wetting agent, or other functions can be added to the binder. Sexual excipients make the operation more controllable; on the other hand, it has good wettability, which can increase the wetting uniformity of the material in the wet granulation process, which is beneficial to both the granulation uniformity and the final product content uniformity; third On the other hand, the high water absorption of microcrystals leads to strong hygroscopicity of preparations. When pure microcrystals are exposed to RH75% for 5 days, the hygroscopic weight gain exceeds 5%, and at RH92.5% for 5 days, the weight gain exceeds 10%. Therefore, when using microcrystals in the prescription, When the proportion of crystals is high, attention should be paid to the issue of hygroscopic stability. Under normal storage conditions, the moisture content of microcrystals is generally about 3% to 5%, and is relatively stable.
  3. Microcrystalline cellulose has poor secondary compression moldability, while lactose is relatively good at this time.
  4. Since microcrystalline cellulose is insoluble in water, a “bottom pressing” phenomenon will occur during the dissolution process, that is, microcrystals accumulate at the bottom of the dissolution vessel in the later stages of dissolution, resulting in incomplete API release. Therefore, for poorly soluble drugs, the general microcrystal ratio is recommended. No more than 30%. If bottoming occurs, the proportion of microcrystals can be reduced or the dissolution speed can be increased (50-75rpm)
  5. In different models of microcrystalline cellulose systems, the general balance relationship is: the better the fluidity, the lower the formability.

The Effects of Microcrystalline Cellulose on the Human Body

Cellulose is the oldest and most abundant natural polymer on Earth, which is inexhaustible and the most precious natural renewable resource for humanity. Cellulose chemistry and industry began more than 160 years ago and were the main research objects during the birth and development of polymer chemistry. The research achievements of cellulose and its derivatives have made significant contributions to the establishment, development, and enrichment of polymer physics and chemistry.


  1. Microcrystalline cellulose – WikiPedia
  2. Encyclopedia of China (Chemistry Volume)

Microcrystalline Cellulose Supplier and Manufacturer

As a microcrystalline cellulose supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best microcrystalline cellulose raw materials to customers all over the world.

Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.

If you have a demand for microcrystalline cellulose and related products, please contact our service staff Zhishang Chemical – White directly, and we will provide you with high-quality products at the best price.

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