Methyl p-toluenesulfonate CAS 80-48-8

Physical and chemical properties
Properties: white crystal;

Melting point: 28-29°C;

Boiling point: 292°C, 146-147°C (1.2kPa);

Relative density: 1.231 (20/4°C);

Stability: Soluble in ethanol, ether, benzene, insoluble in water, hygroscopic.

Use
Methyl p-toluenesulfonate can be used as a selective methylation reagent in organic synthesis; in the manufacture of dyes and in organic synthesis; in the preparation of methylated raw materials, it can be used as a selective methylation reagent and catalyst in organic synthesis. This product is mainly used in medicine, organic synthesis, imaging tape and other industries.

Production method
From the reaction of p-toluenesulfonyl chloride and methanol. Mix p-toluenesulfonyl chloride and methanol, slowly add 25% sodium hydroxide solution, control the temperature below 25°C, stop adding alkali when the pH is 9, continue to stir for 2 hours, and let it stand overnight. Remove the reactant from the lower layer, extract the upper layer with benzene, recover the benzene from the extract and combine it with the lower layer, wash with water and 5% potassium carbonate solution in turn, dry and distill under reduced pressure to obtain methyl p-toluenesulfonate.

Physical and chemical properties
Properties: colorless monoclinic crystal;

Melting point: 32-33°C;

Boiling point: 221.3°C, 173°C (2.0kPa), 165-166°C (1.2kPa);

Relative density: 1.166 (46/6°C);

Refractive index: 1.5110;

Flash point: 157°C.

Stability: Soluble in ethanol, ether, benzene, insoluble in water; unstable in nature.

Use
Ethyl p-toluenesulfonate can be used in organic synthesis as an ethylating agent, in the pharmaceutical industry to produce benzyl ammonium bromide, and as an intermediate of photosensitive materials; in organic synthesis, as an intermediate between ethylating reagents and photosensitive materials Body, but also the toughening agent of cellulose acetate.

Production method
From the esterification of p-toluenesulfonyl chloride and ethanol. Add p-toluenesulfonyl chloride to absolute ethanol as well as liquify with slight warmth. Gradually include salt hydroxide remedy dropwise at 10-12 ° C, the temperature does not sur pass 15 ° C, gauge the pH value every half a hr, and maintain it at 9.3-9.7 for 4 hours. Add ice water and also cool to 0 ° C to speed up crystals. Filter and dry to obtain ethyl p-toluenesulfonate.