Methyl p-toluenesulfonate CAS 80-48-8
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- Appearance: Colorless liquid
- Purity: 99. 0%min
- Stock: In stock
- Sample: Available
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Methyl p-toluenesulfonate: The Complete Guide
Methyl p-toluenesulfonate for Sale
|Chemical Name:||Methyl p-toluenesulfonate|
|Other Name:||Methyl-4-toluene sulfonate; 4-Methyl-benzenesulfonicacimethylester|
|Type:||Flavors and fragrances; Pharmaceuticals, dyes, synthetic material intermediates; Pharmaceutical raw materials; Organic raw materials|
What is Methyl p-toluenesulfonate?
Methyl p-toluenesulfonate is also referred to as methyl 4-toluenesulfonate. White crystals. Soluble in ethanol, ether, benzene, insoluble in water. bothersome. Hygroscopic. Utilized as a selective methylation reagent in natural synthesis. From the response of p-toluenesulfonyl chloride and also methanol. The commercial synthesis of methyl p-toluenesulfonate generally uses concentrated sulfuric acid as a stimulant for straight esterification reaction, yet there are many by-products when focused sulfuric acid is made use of as a driver, and the water down sulfuric acid created has significant rust on tools, as well as the separation of products is complicated and the yield is low, major pollution and other imperfections. The response conditions are rough, the process is complicated, and the product yield is low. As a result, seeking an approach for preparing methyl p-toluenesulfonate with basic procedure conditions, ecological friendliness and higher yield is still a location in this field.
From the reaction of p-toluenesulfonyl chloride and methanol. Mix p-toluenesulfonyl chloride and methanol, slowly add 25% salt hydroxide option, manage the temperature level below 25 ° C, stop adding antacids when the pH is 9, continue to stir for 2 hours, and let it stand overnight. Take the catalysts from the reduced layer, essence the top layer with benzene, recover the benzene from the remove, incorporate it with the reduced layer, laundry with water and also 5% potassium carbonate remedy in turn, completely dry it and afterwards distill it under reduced stress to get the completed product.
Methyl p-toluenesulfonate Uses
Methyl 4-toluenesulfonate, likewise called Methyl p-toluenesulfonate, is a vital organic chemical intermediate, mostly made use of in the manufacture of dyes and natural synthesis, as basic materials for the prep work of methylation, etc.
Methyl 4-toluenesulfonate can be used as a selective methylation reagent in natural synthesis, made use of in the manufacture of dyes and natural synthesis, as a raw material for the preparation of methylation, as a selective methylation reagent and stimulant in organic synthesis.
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Application of Methyl p-toluenesulfonate
Methyl p-toluenesulfonate is used as a selective methylation reagent for organic synthesis, for the manufacture of dyes and organic synthesis, as a raw material for the preparation of methylation, as a selective methylation reagent and catalyst for organic synthesis, and its applications are as follows:
The synthesis process is divided into two steps: 1. Using absolute ethanol as a solvent, carry out the reaction of 4-methylpyridine and methyl p-toluenesulfonate to prepare 4-methyl-N-methylpyridine p-toluenesulfonate Absolute ethanol solution; 2. With absolute ethanol as solvent, under the catalysis of di-n-butylamine or piperidine, through 4-methyl-N-methylpyridine p-toluenesulfonate and p-dimethylaminobenzene The reaction of formaldehyde can obtain DAST source powder with a high yield of 85-95% and a high purity of 90-95%.
The use of absolute ethanol as the reaction solvent avoids the harm to the operator’s body caused by toxic and harmful solvents such as toluene and methanol, and also reduces the pollution of the waste liquid to the environment; the successful development of the invention is conducive to the cultivation of high-quality, large-sized DAST Crystals have laid a good material and theoretical foundation for the research of DAST crystals and related products.
Mix 4-methylpyridine and methyl p-toluenesulfonate in anhydrous methanol and pour it into a three-hole flask for ion exchange reaction; then dissolve p-dimethylaminobenzaldehyde in anhydrous methanol and place in Carry out condensation reflux reaction in a three-hole flask to obtain a crystalline product; the obtained crystalline product is washed with chloroform and filtered quickly to obtain a solid with a green metallic luster, and then the solid with a green metallic luster is heated and completely dissolved in anhydrous Methanol is cooled and air-dried for recrystallization to prepare 4-(4-dimethylaminostyryl)picoline p-toluenesulfonate; the preparation method is simple, the reaction steps are simple, the reaction time is short, the cost is low, and the yield is high.
Comparison of Methyl p-toluenesulfonate and Ethyl p-toluenesulfonate
Physical and chemical properties
Properties: white crystal;
Melting point: 28-29°C;
Boiling point: 292°C, 146-147°C (1.2kPa);
Relative density: 1.231 (20/4°C);
Stability: Soluble in ethanol, ether, benzene, insoluble in water, hygroscopic.
Methyl p-toluenesulfonate can be used as a selective methylation reagent in organic synthesis; in the manufacture of dyes and in organic synthesis; in the preparation of methylated raw materials, it can be used as a selective methylation reagent and catalyst in organic synthesis. This product is mainly used in medicine, organic synthesis, imaging tape and other industries.
From the reaction of p-toluenesulfonyl chloride and methanol. Mix p-toluenesulfonyl chloride and methanol, slowly add 25% sodium hydroxide solution, control the temperature below 25°C, stop adding alkali when the pH is 9, continue to stir for 2 hours, and let it stand overnight. Remove the reactant from the lower layer, extract the upper layer with benzene, recover the benzene from the extract and combine it with the lower layer, wash with water and 5% potassium carbonate solution in turn, dry and distill under reduced pressure to obtain methyl p-toluenesulfonate.
Methyl p-toluenesulfonate Supplier and Manufacturer
As a methyl p-toluenesulfonate supplier and manufacturer with a strict standard product quality system certificate, Zhishang Chemical has long been providing the best methyl p-toluenesulfonate raw materials to customers all over the world.
Over the years, relying on professional team experience and customer-centric team concept to meet customer needs in a timely manner, our company enjoys a high reputation in the world. At present, our company has served more than 6,000 customers and has established long-term cooperative relations with customers from many countries.
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