SHANDONG ZHISHANG CHEMICAL CO.LTD.

Lithium Heparin CAS 9045-22-1

Factory Supply Lithium Heparin CAS 9045-22-1 with Best Price

  • Appearance: White powder
  • Assay: 99. 0%min
  • Stock: In stock
  • Sample: Available

Basic Info of Lithium Heparin

What is Lithium Heparin?

Heparin is actually a mucopolysaccharide containing sulfuric acid groups. It is found in the liver and has the characteristics of strong negative charge and strong acidity. It is mainly extracted from porcine intestinal mucosa or bovine lung. Heparin can accelerate the inactivation of thrombin, improve its affinity, inhibit the aggregation of platelets, enhance the activity of protein C, have a strong regulatory effect on angiogenesis, and also play an anti-allergic and anti-inflammatory role. The more common heparin salts in clinical practice include sodium heparin and lithium heparin. Among them, the low cost of sodium heparin is not conducive to the detection of sodium ions, and its application value is lower than that of lithium heparin.

The study showed that there was no significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, and CRP between the plasma anticoagulated with lithium heparin and serum (P>0.05). There were statistically significant differences in the detection results of HBD, LDH and TBA between lithium heparin anticoagulated plasma and serum (P<0.05). Therefore, in addition to HBD, LDH, and TBA, the correlation between lithium heparin anticoagulated plasma and serum is good. Therefore, it is more feasible to use heparin lithium anticoagulated plasma instead of serum in life detection, and it can be used as an important detection method.

Lithium Heparin Uses

  1. Lithium heparin can accelerate the inactivation of thrombin, improve its affinity, inhibit platelet aggregation, enhance protein C activity, and regulate angiogenesis.
  2. In the detection of Ph value, blood gas, electrolytes and calcium ions, heparin is the only anticoagulant that can be used, and lithium heparin is the least likely to interfere in the detection of non-lithium ions, so lithium heparin is recommended as an anticoagulant.
  3. Lithium heparin basically contains no foreign ions. It should not be used to detect lithium in blood.

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Application of Lithium Heparin

Heparin, sodium salt and lithium salt are common in clinical blood test, and has unique application value. Therefore, heparin is recommended as an anticoagulant in a variety of tests using whole blood or plasma as specimens. In the detection of pH, blood gas, electrolytes and calcium ions, heparin is the only anticoagulant that can be used, and lithium heparin is the least likely to interfere when detecting non-lithium ions, so lithium heparin is recommended as an anticoagulant. , Currently in blood tests, lithium heparin is gradually replacing heparin sodium.

The blood samples of patients after hemodialysis are a special kind of sample that many hospital laboratory departments have to face, and many laboratory personnel often feel helpless when faced with such samples. This is because dialysis patients use anticoagulant drugs containing heparin, such as low molecular weight heparin calcium, etc., during the hemodialysis process. At this time, because the blood contains a certain amount of heparin anticoagulant drugs, the blood is drawn and placed in an ordinary tube or a separating gel. / The coagulant tube is not easy to coagulate, and it is not easy to separate the serum.

It has been reported that using lithium heparin anticoagulant plasma and serum to detect blood K, the analysis of the detection results is biased, which may be because the rotation speed of the blood sample is too high during the centrifugation process, and the red blood cells in the blood clot trapped by the fibrin wire are crushed and destroyed. caused by the release of K ions into serum. In addition, a small amount of red blood cells is inevitably destroyed in the blood sample during the transport and coagulation process, resulting in a mildly high blood K.

It is also reported that there is a significant difference in the detection of CK-MB, LDH, GLU, etc. with lithium heparin anticoagulant plasma and serum, which may be due to hemolysis of the specimen or the decomposition of blood sugar after too long storage time. On the contrary, heparin anticoagulant has the advantage of not affecting the cell volume and not easy to cause hemolysis. It does not need to be placed in a water bath and can be centrifuged directly. The blood K, GLU, LDH, etc. measured by Lithium heparin anticoagulated plasma are more accurate to the actual concentration in the patient’s body. Therefore, establishing a reference value system for plasma biochemical tests as soon as possible will help clinicians make accurate judgments on patients’ conditions.

The research results show that most routine biochemical tests can use lithium heparin anticoagulant plasma instead of serum, but Glu, K+, Na+, CI-, P3- should establish the plasma reference range, and serum reference can be used for other items The range interprets the plasma test results; Lp(a), PA, HBDH, LDH, CK, CKMB, IgM and other items should not be measured with lithium heparin anticoagulated plasma samples, and plasma Lp(a) increases with the increase of heparin concentration.

Preparation of Lithium Heparin

  1. Enzymatic hydrolysis of crude heparin: dissolve crude heparin sodium, adjust the pH to 7.5-9.0, heat up to 50-55°C, add heparin enzymatic hydrolysis of trypsin, keep the temperature for 4-5 hours, adjust the pH to 9.0-11, After heating to 85°C~90°C, cooling, filtering to remove the precipitate, the filtrate was precipitated with ethanol, and the precipitate (A) was collected;
  2. Deproteinization: Dissolve the precipitate (A) obtained in step 1 with water, stir, adjust the pH to 9-11, add a protein flocculating precipitant, stir, let stand, filter to remove the precipitate, collect the filtrate (D), the filtrate (D) Adjust pH to 11-13 value, stir, let stand, filter to remove precipitation, collect filtrate (E), adjust pH value of filtrate (E) to neutrality, use ethanol precipitation, collect precipitate (B);
  3. Oxidative decolorization: dissolve the precipitate (B) obtained in step 2 with water, use hydrogen peroxide for 24-48 hours, adjust the pH to 10.5-11.5, remove the precipitate by filtration, collect the filtrate (F), the filtrate (F) Adjust the pH value to 6.5-7.5, precipitate with ethanol, and collect the precipitate (C);
  4. Resin exchange: Dissolve the precipitate (C) obtained in step 3 with water, add LiCl, stir to dissolve, carry out ion exchange through the resin column, collect the column effluent, and obtain a lithium heparin solution;
  5. Precipitation, dehydration and drying: The lithium heparin solution obtained in step 4 is filtered, precipitated with ethanol, the precipitate (G) is collected, the precipitate (G) is dehydrated, then vacuum dried and pulverized to obtain a fine lithium heparin.

Quality Control of Lithium Heparin

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Comments from Customers

Chancelle Makongo
Chancelle MakongoReland
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Its been an absolute pleasure working with this supplier they offered me kindness, support, kept in contact with right up util receive the product the quality is excellent and shipping was fast. overall | am happy and will be returning back for more.
Lio Lechat
Lio LechatSwitzerland
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I can only advise to do business with because the service is excellent!
Thomas Rsel
Thomas RselAustralia
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Great company! thanks from Australia for good product quality, correct product, good customer service using chat.. delivery speed was ok, via FedEx. the Alibaba App finally makes it safer, so good companies like Shandong Zhi Shang can do business with us, I don't have to worry now with Alipay. Everything is safe for me now, I can't go wrong. frst time payments can just use card, the seller never knows your details, only Alibaba does the payment, so the risk is gone, delivery on time is guaranteed, and because the seller can't see your card details, scammers can't use this system, only good companies that do the right thing can make money here. it really is a much better system now.
Daniel Simonson
Daniel SimonsonUnited States
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Great service - the order arrived sealed in a metal can, perfect for shipping. The can was dented but intact.Shipping from China is rough!
rintero ariura
rintero ariuraJapan
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The product was good and the person who dealt with it was kind!
Rene van Buuren
Rene van BuurenJnited Kingdom
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Mary once again exceeded expectations with her friendly, helpful, professional service. I feel very confdent in this company and its products and will definitely be placing further orders in the future.
Barbara Mohar
Barbara MoharSlovenia
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I general, was very satisfied with the supplier. Basic analyzes (m.p.. FTIR) of the product in our facility confirmed its high quality. Further analyzes are planned, but due to the COVID-19 pandemic, most laboratories in Slovenia are closed.
Sergio Masala
Sergio MasalaSpain
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At this moment I did two mini batches of soap with a very good result. But Ihave to improve my procedure in this techinc. Thank you.
Bassam Zaidan
Bassam ZaidanSaudi Arabia
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The product has a very good quality and it was what we were looking for. shipping was on-time even due COVID-19. the supplier was very responsive and with us all the way.
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