Lithium Heparin CAS 9045-22-1
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- Appearance: White powder
- Assay: 99. 0%min
- Stock: In stock
- Sample: Available
Lithium Heparin: The Complete Guide
Index of Lithium Heparin Contents
Lithium Heparin on Sale
Basic Info of Lithium Heparin
Heparin lithium salt; Lithium Heparin;Lithium heparin ( Injection grade); Lithium cholate
What is Lithium Heparin?
Heparin is actually a mucopolysaccharide containing sulfuric acid groups. It is found in the liver and has the characteristics of strong negative charge and strong acidity. It is mainly extracted from porcine intestinal mucosa or bovine lung. Heparin can accelerate the inactivation of thrombin, improve its affinity, inhibit the aggregation of platelets, enhance the activity of protein C, have a strong regulatory effect on angiogenesis, and also play an anti-allergic and anti-inflammatory role. The more common heparin salts in clinical practice include sodium heparin and lithium heparin. Among them, the low cost of sodium heparin is not conducive to the detection of sodium ions, and its application value is lower than that of lithium heparin.
The study showed that there was no significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, and CRP between the plasma anticoagulated with lithium heparin and serum (P>0.05). There were statistically significant differences in the detection results of HBD, LDH and TBA between lithium heparin anticoagulated plasma and serum (P<0.05). Therefore, in addition to HBD, LDH, and TBA, the correlation between lithium heparin anticoagulated plasma and serum is good. Therefore, it is more feasible to use heparin lithium anticoagulated plasma instead of serum in life detection, and it can be used as an important detection method.
Lithium Heparin Uses
- Lithium heparin can accelerate the inactivation of thrombin, improve its affinity, inhibit platelet aggregation, enhance protein C activity, and regulate angiogenesis.
- In the detection of Ph value, blood gas, electrolytes and calcium ions, heparin is the only anticoagulant that can be used, and lithium heparin is the least likely to interfere in the detection of non-lithium ions, so lithium heparin is recommended as an anticoagulant.
- Lithium heparin basically contains no foreign ions. It should not be used to detect lithium in blood.
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Application of Lithium Heparin
Heparin, sodium salt and lithium salt are common in clinical blood test, and has unique application value. Therefore, heparin is recommended as an anticoagulant in a variety of tests using whole blood or plasma as specimens. In the detection of pH, blood gas, electrolytes and calcium ions, heparin is the only anticoagulant that can be used, and lithium heparin is the least likely to interfere when detecting non-lithium ions, so lithium heparin is recommended as an anticoagulant. , Currently in blood tests, lithium heparin is gradually replacing heparin sodium.
The blood samples of patients after hemodialysis are a special kind of sample that many hospital laboratory departments have to face, and many laboratory personnel often feel helpless when faced with such samples. This is because dialysis patients use anticoagulant drugs containing heparin, such as low molecular weight heparin calcium, etc., during the hemodialysis process. At this time, because the blood contains a certain amount of heparin anticoagulant drugs, the blood is drawn and placed in an ordinary tube or a separating gel. / The coagulant tube is not easy to coagulate, and it is not easy to separate the serum.
It has been reported that using lithium heparin anticoagulant plasma and serum to detect blood K, the analysis of the detection results is biased, which may be because the rotation speed of the blood sample is too high during the centrifugation process, and the red blood cells in the blood clot trapped by the fibrin wire are crushed and destroyed. caused by the release of K ions into serum. In addition, a small amount of red blood cells is inevitably destroyed in the blood sample during the transport and coagulation process, resulting in a mildly high blood K.
It is also reported that there is a significant difference in the detection of CK-MB, LDH, GLU, etc. with lithium heparin anticoagulant plasma and serum, which may be due to hemolysis of the specimen or the decomposition of blood sugar after too long storage time. On the contrary, heparin anticoagulant has the advantage of not affecting the cell volume and not easy to cause hemolysis. It does not need to be placed in a water bath and can be centrifuged directly. The blood K, GLU, LDH, etc. measured by Lithium heparin anticoagulated plasma are more accurate to the actual concentration in the patient’s body. Therefore, establishing a reference value system for plasma biochemical tests as soon as possible will help clinicians make accurate judgments on patients’ conditions.
The research results show that most routine biochemical tests can use lithium heparin anticoagulant plasma instead of serum, but Glu, K+, Na+, CI-, P3- should establish the plasma reference range, and serum reference can be used for other items The range interprets the plasma test results; Lp(a), PA, HBDH, LDH, CK, CKMB, IgM and other items should not be measured with lithium heparin anticoagulated plasma samples, and plasma Lp(a) increases with the increase of heparin concentration.
Preparation of Lithium Heparin
- Enzymatic hydrolysis of crude heparin: dissolve crude heparin sodium, adjust the pH to 7.5-9.0, heat up to 50-55°C, add heparin enzymatic hydrolysis of trypsin, keep the temperature for 4-5 hours, adjust the pH to 9.0-11, After heating to 85°C～90°C, cooling, filtering to remove the precipitate, the filtrate was precipitated with ethanol, and the precipitate (A) was collected;
- Deproteinization: Dissolve the precipitate (A) obtained in step 1 with water, stir, adjust the pH to 9-11, add a protein flocculating precipitant, stir, let stand, filter to remove the precipitate, collect the filtrate (D), the filtrate (D) Adjust pH to 11-13 value, stir, let stand, filter to remove precipitation, collect filtrate (E), adjust pH value of filtrate (E) to neutrality, use ethanol precipitation, collect precipitate (B);
- Oxidative decolorization: dissolve the precipitate (B) obtained in step 2 with water, use hydrogen peroxide for 24-48 hours, adjust the pH to 10.5-11.5, remove the precipitate by filtration, collect the filtrate (F), the filtrate (F) Adjust the pH value to 6.5-7.5, precipitate with ethanol, and collect the precipitate (C);
- Resin exchange: Dissolve the precipitate (C) obtained in step 3 with water, add LiCl, stir to dissolve, carry out ion exchange through the resin column, collect the column effluent, and obtain a lithium heparin solution;
- Precipitation, dehydration and drying: The lithium heparin solution obtained in step 4 is filtered, precipitated with ethanol, the precipitate (G) is collected, the precipitate (G) is dehydrated, then vacuum dried and pulverized to obtain a fine lithium heparin.