Lithium Heparin CAS 9045-22-1

The blood samples of patients after hemodialysis are a special kind of sample that many hospital laboratory departments have to face, and many laboratory personnel often feel helpless when faced with such samples. This is because dialysis patients use anticoagulant drugs containing heparin, such as low molecular weight heparin calcium, etc., during the hemodialysis process. At this time, because the blood contains a certain amount of heparin anticoagulant drugs, the blood is drawn and placed in an ordinary tube or a separating gel. / The coagulant tube is not easy to coagulate, and it is not easy to separate the serum.

It has been reported that using lithium heparin anticoagulant plasma and serum to detect blood K, the analysis of the detection results is biased, which may be because the rotation speed of the blood sample is too high during the centrifugation process, and the red blood cells in the blood clot trapped by the fibrin wire are crushed and destroyed. caused by the release of K ions into serum. In addition, a small amount of red blood cells is inevitably destroyed in the blood sample during the transport and coagulation process, resulting in a mildly high blood K.

It is also reported that there is a significant difference in the detection of CK-MB, LDH, GLU, etc. with lithium heparin anticoagulant plasma and serum, which may be due to hemolysis of the specimen or the decomposition of blood sugar after too long storage time. On the contrary, heparin anticoagulant has the advantage of not affecting the cell volume and not easy to cause hemolysis. It does not need to be placed in a water bath and can be centrifuged directly. The blood K, GLU, LDH, etc. measured by Lithium heparin anticoagulated plasma are more accurate to the actual concentration in the patient’s body. Therefore, establishing a reference value system for plasma biochemical tests as soon as possible will help clinicians make accurate judgments on patients’ conditions.

The research results show that most routine biochemical tests can use lithium heparin anticoagulant plasma instead of serum, but Glu, K+, Na+, CI-, P3- should establish the plasma reference range, and serum reference can be used for other items The range interprets the plasma test results; Lp(a), PA, HBDH, LDH, CK, CKMB, IgM and other items should not be measured with lithium heparin anticoagulated plasma samples, and plasma Lp(a) increases with the increase of heparin concentration.